Nature Search

Methylguanidine, a Naturally Occurring Compound showing Mutagenicity after Nitrosation in Gastric Juice

HIDEYA ENDO
KOICHI TAKAHASHI
Research01 Oct 1973
Nature

Volume: 245, P: 325-326
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084

Takeshi Isoda
Hideki Ushirogochi
Yoshimitsu Nagao
Research01 Apr 2006
The Journal of Antibiotics

Volume: 59, P: 241-247
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
¹³C NMR Studies of Solvent-induced Helix-Coil Transitions of Poly(γ-phenethyl-L-glutamate) and Poly[γ-(3-phenylpropyl)-L-glutamate]

Yoshio Inoue
Kôichi Kuhara
Riichirô Chûjô
Research01 Aug 1982
Polymer Journal

Volume: 14, P: 659-665
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan

Yutaka Kitamura
Kaori Minobe
M. Emi
Research01 Mar 1999
Journal of Human Genetics

Volume: 44, P: 96-102
Endometrial injection of embryo culture supernatant adversely affects assisted reproductive technology outcomes in frozen thawed embryo transfer cycles

Ayumu Ito
Yukiko Katagiri
Masahiko Nakata
ResearchOpen Access29 Mar 2025
Scientific Reports

Volume: 15, P: 1-8
The impact of landscape structure on pesticide exposure to honey bees

Pesticides must be evaluated for their exposure to honey bees across diverse landscapes. This study reveals that both agricultural lands and urban areas resulted in higher pesticide exposure of bees, whereas forests were considered pesticide mitigation areas.

Shumpei Hisamoto
Makihiko Ikegami
Yoshiko Sakamoto
ResearchOpen Access22 Oct 2024
Nature Communications

Volume: 15, P: 1-11
A method for utilizing automated machine learning for histopathological classification of testis based on Johnsen scores

Yurika Ito
Mami Unagami
Hideyuki Kobayashi
ResearchOpen Access10 May 2021
Scientific Reports

Volume: 11, P: 1-11
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

Koichi Kikuchi
Daisuke Saigusa
Takaaki Abe
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-17
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Soft chromophore featured liquid porphyrins and their utilization toward liquid electret applications

Though electret materials are attractive for realizing flexible mechanoelectrical devices, these materials are typically solid films. Here, the authors report stretchable ‘liquid-electret’ devices consisting solvent-free liquid porphyrins that show piezoelectric and electroacoustic functionality.

Avijit Ghosh
Manabu Yoshida
Takashi Nakanishi
ResearchOpen Access30 Sept 2019
Nature Communications

Volume: 10, P: 1-9
Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Hair follicle–derived cytokines control the tropism and retention of memory T cells in the skin and promote lymphoma.

Takeya Adachi
Tetsuro Kobayashi
Keisuke Nagao
Research19 Oct 2015
Nature Medicine

Volume: 21, P: 1272-1279
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Primary Large-Cell Neuroendocrine Carcinoma of the Parotid Gland: Immunohistochemical and Molecular Analysis of Two Cases

Toshitaka Nagao
Isamu Sugano
Koichi Nagao
Research01 May 2000
Modern Pathology

Volume: 13, P: 554-561
Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling

Endothelin-1 regulates cardiovascular development by acting on neural crest cells. Here endothelin-1-deficient mice are studied, revealing that preotic neural crest cells differentiate into coronary artery smooth muscle cells through endothelin-1-dependent mechanisms.

Yuichiro Arima
Sachiko Miyagawa-Tomita
Hiroki Kurihara
Research11 Dec 2012
Nature Communications

Volume: 3, P: 1-11
A new model for determining risk of male infertility from serum hormone levels, without semen analysis

Hideyuki Kobayashi
Masato Uetani
Koichi Nagao
ResearchOpen Access31 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Longitudinal change in castration-resistant prostate cancer biomarker AST/ALT ratio reflects tumor progression

Yozo Mitsui
Fumito Yamabe
Koichi Nakajima
ResearchOpen Access15 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Neoadjuvant therapy-induced immune dynamics and myeloid-associated resistance in advanced head and neck cancer

Alisa Kimura
Junichi Mitsuda
Takahiro Tsujikawa
ResearchOpen Access07 Jun 2025
npj Precision Oncology

Volume: 9, P: 1-9
A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction

Michiaki Kubo
Jun Hata
Yutaka Kiyohara
Research07 Jan 2007
Nature Genetics

Volume: 39, P: 212-217
Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

Shigetomo Fukuhara
Keisuke Sako
Naoki Mochizuki
ReviewsOpen Access31 Mar 2009
Experimental & Molecular Medicine

Volume: 41, P: 133-139
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Molecular dynamics and structure of polyrotaxane in solution

This paper reviews our X-ray and neutron scattering experiments on the molecular structure and dynamics of a supramolecular assembly, polyrotaxane (PR) composed of polyethylene glycol (PEG) and α-cyclodextrin (CD). Inclusion complex formation with CDs increases the stiffness of the PEG backbone and restricts the diffusion of the PEG monomers that are covered by or in close proximity to the CD molecules.

Koichi Mayumi
Reviews27 Jan 2021
Polymer Journal

Volume: 53, P: 581-586

Search

Methylguanidine, a Naturally Occurring Compound showing Mutagenicity after Nitrosation in Gastric Juice

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084

DOCK2 is involved in the host genetics and biology of severe COVID-19

¹³C NMR Studies of Solvent-induced Helix-Coil Transitions of Poly(γ-phenethyl-L-glutamate) and Poly[γ-(3-phenylpropyl)-L-glutamate]

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Blood DNA virome associates with autoimmune diseases and COVID-19

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Ret/PTC3 is the most frequent form of gene rearrangement in papillary thyroid carcinomas in Japan

Endometrial injection of embryo culture supernatant adversely affects assisted reproductive technology outcomes in frozen thawed embryo transfer cycles

The impact of landscape structure on pesticide exposure to honey bees

A method for utilizing automated machine learning for histopathological classification of testis based on Johnsen scores

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Soft chromophore featured liquid porphyrins and their utilization toward liquid electret applications

Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Primary Large-Cell Neuroendocrine Carcinoma of the Parotid Gland: Immunohistochemical and Molecular Analysis of Two Cases

Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling

A new model for determining risk of male infertility from serum hormone levels, without semen analysis

Longitudinal change in castration-resistant prostate cancer biomarker AST/ALT ratio reflects tumor progression

Neoadjuvant therapy-induced immune dynamics and myeloid-associated resistance in advanced head and neck cancer

A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction

Tie2 is tied at the cell-cell contacts and to extracellular matrix by Angiopoietin-1

Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Molecular dynamics and structure of polyrotaxane in solution

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