Nature Search

Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD

Here, the authors clarify the architecture of genetic risk on chromosome X in three male-biased psychiatric disorders. Leveraging this information they identify an exome-wide significant autism risk gene, MAGEC3, and provide a path forward for future gene discovery on this chromosome.

Sheng Wang
Belinda Wang
A. Jeremy Willsey
ResearchOpen Access06 Dec 2023
Nature Communications

Volume: 14, P: 1-18
Murine maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehaviour

Malnutrition during pregnancy has lasting effects on maternal and offspring health. Its adverse impacts are modified by the maternal microbiome and attenuated by gestational treatment with select microbial metabolites.

Elena J. Coley-O’Rourke
Gregory R. Lum
Elaine Y. Hsiao
Research13 Jun 2025
Nature Microbiology

Volume: 10, P: 1648-1664
Multiple outflows and delayed ejections revealed by early imaging of novae

Early high-resolution images of two 2021 novae reveal eruptions unfolding in multiple stages with colliding outflows that produce shocks and gamma rays, reshaping our understanding of stellar explosions.

Elias Aydi
John D. Monnier
Anna V. Payne
ResearchOpen Access05 Dec 2025
Nature Astronomy

P: 1-10
A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts

Richard G. W. Anderson
Joseph L. Goldstein
Michael S. Brown
Research01 Dec 1977
Nature

Volume: 270, P: 695-699
Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder

Autism spectrum disorder is a complex disease with a strong genetic basis that remains under-characterized by current genetics studies. Here, the authors use a computational approach based on a human brain-specific gene network to predict autism-associated genes across the genome and further delineate their functional and developmental characteristics.

Arjun Krishnan
Ran Zhang
Olga G Troyanskaya
Research01 Aug 2016
Nature Neuroscience

Volume: 19, P: 1454-1462
Understanding opposing predictions of Prochlorococcus in a changing climate

This work explains how the spatial structuring of populations, focusing on the globally dominant phytoplankton Prochlorococcus, can lead to erroneous statistical predictions for changes in plankton abundance as the ocean warms. Conflicting predictions of dynamical and statistical models for this biogeochemically critical species are resolved.

Vincent Bian
Merrick Cai
Christopher L. Follett
ResearchOpen Access15 Mar 2023
Nature Communications

Volume: 14, P: 1-10
Variations in the α_s-Casein Fraction of Individual Cow's Milk

M. P. THOMPSON
C. A. KIDDY
C. A. ZITTLE
Research08 Sept 1962
Nature

Volume: 195, P: 1001-1002
A variant of the mammalian somatotopic map in a bat

M. B. Calford
M. L. Graydon
J. D. Pettigrew
Research07 Feb 1985
Nature

Volume: 313, P: 477-479
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia

The impact of neurodevelopmental mutations on functional brain connectivity is poorly understood. Here the authors identify thalamo-sensorimotor dysconnectivity dimensions shared across 16p11.2 and 22q11.2 copy number variants, autism and schizophrenia, but not ADHD.

Clara A. Moreau
Sebastian G. W. Urchs
Sebastien Jacquemont
ResearchOpen Access19 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Cranial anatomy and implications of Dolichocebus, a late Oligocene ceboid primate

ALFRED L. ROSENBERGER
Research01 May 1979
Nature

Volume: 279, P: 416-418
Vulnerability to memory decline in aging revealed by a mega-analysis of structural brain change

Across 13 longitudinal studies (3,737 adults), the authors show that brain atrophy parallels memory loss, with a stronger coupling in later life. APOE ε4 increases decline, yet genetic risk does not modify the brain–memory relationship.

Didac Vidal-Piñeiro
Øystein Sørensen
Anders M. Fjell
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Basis for selective drug evasion of an aminoglycoside-resistance ribosomal RNA modification

RNA methylation can result in bacterial resistance to ribosome-targeting antibiotics like aminoglycosides. Here, the authors reveal how some aminoglycosides are able to partially evade one such RNA modification, providing design principles for new analogs with retained potency on modified ribosomes.

Debayan Dey
Jacob M. Mattingly
Graeme L. Conn
ResearchOpen Access27 Aug 2025
Nature Communications

Volume: 16, P: 1-16
An extremely luminous flare recorded from a supermassive black hole

An extreme flare has been seen from a supermassive black hole at redshift z = 2.6. First detected in 2018, it is 30 times brighter than similar events. The most likely cause is the shredding of a star of 30 solar masses or more.

Matthew J. Graham
Barry McKernan
Ashish Mahabal
Research04 Nov 2025
Nature Astronomy

Volume: 10, P: 154-164
Sexual dimorphism in early anthropoids (reply)

JOHN G. FLEAGLE
RICHARD F. KAY
ELWYN L. SIMONS
Research16 Apr 1981
Nature

Volume: 290, P: 609
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

Whole-exome sequencing of 250 parent–offspring trios identifies an enrichment of rare damaging de novo mutations in individuals with cerebral palsy and implicates genetically mediated dysregulation of early neuronal connectivity in the etiology of this disorder.

Sheng Chih Jin
Sara A. Lewis
Michael C. Kruer
Research28 Sept 2020
Nature Genetics

Volume: 52, P: 1046-1056
Assembly of GABA_A receptor subunits determines sorting and localization in polarized cells

Jose L. Perez-Velazquez
Kimon J. Angelides
Research04 Feb 1993
Nature

Volume: 361, P: 457-460
Apidium and Oreopithecus

ELWYN L. SIMONS
Research04 Jun 1960
Nature

Volume: 186, P: 824-826
Paternal-age-related de novo mutations and risk for five disorders

Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart disease and schizophrenia.

Jacob L. Taylor
Jean-Christophe P. G. Debost
Elise B. Robinson
ResearchOpen Access10 Jul 2019
Nature Communications

Volume: 10, P: 1-9
Evidence for improved DNA repair in the long-lived bowhead whale

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.

Denis Firsanov
Max Zacher
Vera Gorbunova
ResearchOpen Access29 Oct 2025
Nature

Volume: 648, P: 717-725
Late Eocene of Burma yields earliest anthropoid primate, Pondaungia cotteri

Ba Maw
Russell L. Ciochon
Donald E. Savage
Research01 Nov 1979
Nature

Volume: 282, P: 65-67
Biological Sciences: Humerus of Dryopithecus from Saint Gaudens, France

D. R. PILBEAM
E. L. SIMONS
Research05 Feb 1971
Nature

Volume: 229, P: 406-407
Phenotypic effects of genetic variants associated with autism

Analyses of data from more than 200,000 individuals identify phenotypic features associated to carrying variants in autism-associated genes, in individuals with and without a diagnosis of autism.

Thomas Rolland
Freddy Cliquet
Thomas Bourgeron
ResearchOpen Access26 Jun 2023
Nature Medicine

Volume: 29, P: 1671-1680
Photovoltage microscopy of symmetrically twisted trilayer graphene

A proposed theoretical explanation for the electronic behaviour of moiré graphene is the coexistence of light and heavy electrons. Now local thermoelectric measurements hint that this model could be accurate.

Sergi Batlle Porro
Dumitru Călugăru
Frank H. L. Koppens
Research20 Nov 2025
Nature Physics

Volume: 21, P: 1934-1941
Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting

Yan et al. elucidated how the airway and the esophagus split from the foregut tube during embryonic development. They showed that collective migration of mesenchymal cells generates a constricting biomechanical force critical for splitting the epithelial tube.

Rui Yan
Ludwig A. Hoffmann
Clifford J. Tabin
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Relationships of Amphipithecus and Oligopithecus

ELWYN L. SIMONS
Research01 Aug 1971
Nature

Volume: 232, P: 489-491
Appearance of Hipparion in the Tertiary of the Siwalik Hills of North India, Kashmir and West Pakistan

ELWYN L. SIMONS
DAVID PILBEAM
S. J. BOYER
Research05 Feb 1971
Nature

Volume: 229, P: 408-409
Cavity electrodynamics of van der Waals heterostructures

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

Gunda Kipp
Hope M. Bretscher
James W. McIver
ResearchOpen Access20 Oct 2025
Nature Physics

Volume: 21, P: 1926-1933
Limits on the emission of neutrons, γ-rays, electrons and protons from Pons/Fleischmann electrolytic cells

M. H. Salamon
M. E. Wrenn
S. M. Seltzer
Research29 Mar 1990
Nature

Volume: 344, P: 401-405
Efficient quantum thermal simulation

An efficient quantum thermal simulation algorithm that exhibits detailed balance, respects locality, and serves as a self-contained model for thermalization in open quantum systems.

Chi-Fang Chen
Michael Kastoryano
András Gilyén
ResearchOpen Access15 Oct 2025
Nature

Volume: 646, P: 561-566
UBR5 loss-of-function variants in autism spectrum disorder and intellectual disability: case series and review of the literature

Miriam S. Reuter
Nelson Bautista Salazar
Stephen W. Scherer
ResearchOpen Access29 Nov 2025
npj Genomic Medicine

Volume: 11, P: 1-6
Patterned wireless transcranial optogenetics generates artificial perception

This work presents a fully implantable wireless optogenetic device that delivers spatiotemporally patterned cortical stimulation through the skull and generates artificial perception in mice.

Mingzheng Wu
Yiyuan Yang
John A. Rogers
Research08 Dec 2025
Nature Neuroscience

Volume: 29, P: 234-245
Sensory expectations shape neural population dynamics in motor circuits

Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the efficiency of movement responses.

Jonathan A. Michaels
Mehrdad Kashefi
J. Andrew Pruszynski
Research29 Oct 2025
Nature

Volume: 648, P: 668-677
“Newly” Recognized Mandible of Ramapithecus

L. S. B. LEAKEY
Research10 Jan 1970
Nature

Volume: 225, P: 199-200
A parabrachial hub for need-state control of enduring pain

Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Nitsan Goldstein
Amadeus Maes
J. Nicholas Betley
ResearchOpen Access08 Oct 2025
Nature

Volume: 647, P: 689-697
Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk

Application of a deep-learning-based framework shows that individuals with autism spectrum disorder (ASD) harbor regulation-disrupting mutations of higher functional impact than those in unaffected siblings and identifies a convergent genetic landscape of coding and noncoding de novo mutations in ASD.

Jian Zhou
Christopher Y. Park
Olga G. Troyanskaya
Research27 May 2019
Nature Genetics

Volume: 51, P: 973-980
Geomagnetic Polarity Zones for Icelandic Lavas

P. DAGLEY
R. L. WILSON
R. L. GRASTY
Research07 Oct 1967
Nature

Volume: 216, P: 25-29
Spectacle lenses alter eye growth and the refractive status of young monkeys

Li-Fang Hung
M.L.J. Crawford
Earl L. Smith
Research01 Aug 1995
Nature Medicine

Volume: 1, P: 761-765
Mechanistic understanding of nitrate reduction as the dominant production pathway of nitrous oxide in marine oxygen minimum zones

Experiments and modelling unravel mechanisms of nitrous oxide production from nitrate, the primary nitrous oxide production pathway in oxygen minimum zones. Results highlight the critical role of microbial interactions in regulating this pathway.

Xin Sun
Claudia Frey
Emily J. Zakem
ResearchOpen Access07 Oct 2025
Nature Communications

Volume: 16, P: 1-9
Minor contribution of ammonia oxidizers to inorganic carbon fixation in the ocean

Ammonia oxidizers contribute minimally to carbon fixation in the dark ocean despite their abundance at depth, according to enzyme inhibition experiments on water samples from two cruises.

Barbara Bayer
Katharina Kitzinger
Alyson E. Santoro
ResearchOpen Access23 Sept 2025
Nature Geoscience

Volume: 18, P: 1144-1151
Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p

Common polygenic variation at chromosome 16p and rare recurrent deletions of 16p11.2 influencing autism risk are associated with reduced expression of genes throughout the 16p region, suggesting functional convergence of rare and common variant effects.

Daniel J. Weiner
Emi Ling
Elise B. Robinson
ResearchOpen Access24 Oct 2022
Nature Genetics

Volume: 54, P: 1630-1639
Spiral Morphology of Boron Particles

EDWARD L. SIMONS
Research17 Oct 1953
Nature

Volume: 172, P: 724
Porphyrin Abiogenesis from Pyrrole and Formaldehyde under Simulated Geochemical Conditions

G. W. HODGSON
B. L. BAKER
Research07 Oct 1967
Nature

Volume: 216, P: 29-32
Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism

Single-cell analysis of patient brains and cortical organoids links disrupted developmental metabolic reprogramming to postnatal synaptic dysfunction in dup15q syndrome, revealing shared neuronal changes with idiopathic autism.

Yonatan Perez
Dmitry Velmeshev
Arnold Kriegstein
ResearchOpen Access04 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

Analysis of genotyping data for more than 150,000 individuals from the UK Biobank using long-range phase information sheds light on mechanisms of clonal haematopoiesis.

Po-Ru Loh
Giulio Genovese
Alkes L. Price
Research11 Jul 2018
Nature

Volume: 559, P: 350-355
Mapping and characterization of structural variation in 17,795 human genomes

Structural variants in more than 17,000 human genomes are mapped and characterized using whole-genome sequencing, showing how this type of variation contributes to rare deleterious coding and noncoding alleles.

Haley J. Abel
David E. Larson
Ira M. Hall
Research27 May 2020
Nature

Volume: 583, P: 83-89
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Accurate geometric albedo, shape, and size of Hi’iaka from a stellar occultation

Hiʻiaka is the largest moon of the distant dwarf planet Haumea. Here, the authors report the first multi-chord stellar occultations of Hiʻiaka, revealing its size, shape, and density, suggesting an origin from Haumea’s icy mantle.

Estela Fernández-Valenzuela
Jose Luis Ortiz
Dmitry Monin
ResearchOpen Access01 Dec 2025
Nature Communications

Volume: 16, P: 1-11
Soliton confinement in a quantum circuit

The physics of confinement manifested in quantum spin chain models has been recently studied in quantum simulators. Here the authors report a numerical study of confinement of soliton excitations in a nonintegrable bosonic quantum field theory realized with a superconducting quantum electronic circuit.

Ananda Roy
Sergei L. Lukyanov
ResearchOpen Access16 Nov 2023
Nature Communications

Volume: 14, P: 1-6
Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

David G. Cook
Mark S. Forman
Robert W. Doms
Research01 Sept 1997
Nature Medicine

Volume: 3, P: 1021-1023
Cranial Capacity of the Hominine from Olduvai Bed I

RALPH L. HOLLOWAY JUN.
Research09 Oct 1965
Nature

Volume: 208, P: 205-206

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