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Cell Death and Differentiation (2)
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Showing 1–7 of 7 results

Advanced filters: Author: Lanxia Meng Clear advanced filters

Galectin-9 activates microglial asparagine endopeptidase and promotes α-synuclein pathology in Parkinson’s disease

Qinyu Peng
Guoxin Zhang
Zhentao Zhang
Research14 Dec 2025
Cell Death & Differentiation

P: 1-17
Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease

Yuan et al. find that the kidney can serve as a site of initiation for the spread of pathological α-synuclein to the brain, contributing to the development of Parkinson’s disease (PD) and providing a mechanistic link between PD and renal dysfunction.

Xin Yuan
Shuke Nie
Zhentao Zhang
Research23 Jan 2025
Nature Neuroscience

Volume: 28, P: 577-588
GDF1 ameliorates cognitive impairment induced by hearing loss

Pan et al. demonstrate that hearing loss promotes cognitive decline in an APP/PS1 mouse model of Alzheimer disease via inhibition of the GDF1 signaling pathway, unveiling GDF1 as a therapeutic target for Alzheimer disease.

Lina Pan
Chunrui Li
Zhentao Zhang
Research15 Mar 2024
Nature Aging

Volume: 4, P: 568-583
Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease

In this study, the authors found that sTREM2 attenuates tau hyperphosphorylation by activating transgelin-2. They developed an active peptide that mimics the protective effect of sTREM2, which may be an innovative therapeutic intervention for AD.

Xingyu Zhang
Li Tang
Zhentao Zhang
ResearchOpen Access21 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Tau modification by the norepinephrine metabolite DOPEGAL stimulates its pathology and propagation

DOPEGAL, a metabolite of norepinephrine in the locus ceruleus, covalently modifies tau and accelerates its aggregation and propagation, leading to cognitive deficits in Alzheimer’s disease.

Seong Su Kang
Lanxia Meng
Keqiang Ye
Research24 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 292-305
The PM20D1-NADA pathway protects against Parkinson’s disease

Yunying Yang
Sichun Chen
Zhentao Zhang
Research22 Aug 2024
Cell Death & Differentiation

Volume: 31, P: 1545-1560
Chronic stress induces depression-like behaviors and Parkinsonism via upregulating α-synuclein

Danhao Xia
Min Xiong
Zhentao Zhang
ResearchOpen Access28 May 2025
npj Parkinson's Disease

Volume: 11, P: 1-14