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Showing 1–20 of 20 results
Advanced filters: Author: Lawrence Kazak Clear advanced filters

  • The transition from senior postdoc to early-stage investigator is a pivotal step in the careers of academic scientists. In this series, early-stage investigators reflect on their labs’ first publications and the journeys that led them there.

    • Lydia Finley
    • Lawrence Kazak
    Reviews
    Nature Metabolism
    Volume: 2, P: 481-482

  • Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown adipose tissue is, in addition to UCP1, also mediated by a UCP1-independent pathway, called the Futile Creatine Cycle

    • Jakub Bunk
    • Mohammed F. Hussain
    • Lawrence Kazak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Creatine can be used for thermogenesis in adipocytes. Here Kazak et al. show that creatine uptake is required to sustain this thermogenic pathway. Knockdown of the creatine transporter, CrT, in adipocytes decreases thermogenesis and energy expenditure, whereas creatine supplementation increases energy expenditure in mice fed a high-fat diet.

    • Lawrence Kazak
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature Metabolism
    Volume: 1, P: 360-370

  • Creatine chemical exchange saturation transfer magnetic resonance imaging is used successfully to measure brown adipose tissue activity in rats and humans, delivering data that are consistent with [18F]fluorodeoxyglucose PET and CT measurements.

    • Zimeng Cai
    • Qiaoling Zhong
    • Kejia Cai
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 1367-1379

  • The mitochondrial ADP/ATP carrier mediates the proton leak in mitochondria from all tissues that lack UCP1, thereby linking coupled (ATP production) and uncoupled (thermogenesis) energy conversion.

    • Ambre M. Bertholet
    • Edward T. Chouchani
    • Yuriy Kirichok
    Research
    Nature
    Volume: 571, P: 515-520

  • Common protonophores—previously known as protein-independent proton translocators—activate mitochondrial heat production due to H+ leak through the ADP/ATP carrier and uncoupling protein 1.

    • Ambre M. Bertholet
    • Andrew M. Natale
    • Yuriy Kirichok
    Research
    Nature
    Volume: 606, P: 180-187

  • Tissue nonspecific alkaline phosphatase (TNAP) within mitochondria hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation in thermogenic fat cells.

    • Yizhi Sun
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 593, P: 580-585

  • The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

    • Alexander S. Banks
    • David B. Allison
    • Juleen R. Zierath
    Reviews
    Nature Metabolism
    Volume: 7, P: 1765-1780

  • Like nuclear DNA, mitochondrial DNA possesses multiple pathways that function to preserve its integrity following exogenous insults or errors during replication. Because the candidate proteins involved are similar to those carrying out nuclear DNA repair, elucidating the contribution of each repair protein has been challenging.

    • Lawrence Kazak
    • Aurelio Reyes
    • Ian J. Holt
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 659-671

  • Creatine is well known to have a key role in energy buffering; however, new work is showing that creatine also has roles in diverse cell types and physiological conditions that are distinct from this classic role. This Review discusses the role of creatine in adipocyte thermogenesis, immunity and cancer cell survival.

    • Lawrence Kazak
    • Paul Cohen
    Reviews
    Nature Reviews Endocrinology
    Volume: 16, P: 421-436

  • Many patients with cancer experience cachexia, a wasting disorder of adipose tissue and skeletal muscle that leads to weight loss and frailty; now, tumour-derived parathyroid-hormone-related protein has been shown to stimulate the expression of genes involved in heat production in adipose tissues and to have an important role in tissue wasting.

    • Serkan Kir
    • James P. White
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 513, P: 100-104