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The authors present bioinspired solid-state proton diode membranes that achieve rectified proton transport by constructing an inherent water-content gradient and asymmetric transport pathways, enables efficient force-electric conversion.

Precise transcription-repair coordination is required for efficient DSB repair. Here, the authors show that DNA-PK-mediated CRTC2 Ser433 phosphorylation, relocates DNA-PK from transcription to repair complexes and promote NHEJ. Inhibition of CRTC2 sensitizes liver cancer to radioimmunotherapy.

This study demonstrates a breakthrough in all-optical Kerr switches by a silicon-organic hybrid slot nanobeam cavity. It achieves 63 fJ/bit switching energy with 7.5 mW peak power, enabling error-free switching of high-duty-cycle signals.

Artificial intelligence is increasingly used in medical imaging, but its realworld clinical value for report generation is unclear. Here, the authors show that AI assistance in chest X-ray interpretation reduced reading time while maintaining diagnostic accuracy and agreement in a prospective study.

Turning mixed plastic waste into useful products is a major challenge for a circular economy. This study uses a microwave-driven iron-nickel catalyst to convert even halogenated plastic mixtures into hydrogen and carbon nanotubes with high yield and stability.

Hypoxia-driven dysregulated lactate metabolism is a feature of intervertebral disc degeneration (IDD), but biological metabzymes and most biomimetic counterparts are ineffective under hypoxic conditions and often yield harmful metabolites. Here, the authors report a biogenic Fe-N-C artificial metabzyme for IDD metabolic therapy that reprograms lactate metabolism and corrects metabolic dysfunction.

Using solution NMR, the authors show that distinct phosphorylation sites reshape the conformational energy landscape of Hsp90 through different dynamic allosteric pathways, converging on suppression of productive ATPase-cycle progression.

Tin-lead perovskites enable tandem devices to surpass the Shockley-Queisser limit, but oxidation of tin severely degrades film quality and performance. Jiang et al. stabilize bulk and surface with two natural antioxidants, boosting both single- and tandem-device efficiency and stability.

The authors propose a 3D holographic method that generates physically consistent complex-valued light fields from multi-layer RGB-D data, achieving photorealistic defocus effects in scenes with transparency and reflection.

Cation degradation limits the durability of anion exchange membrane water electrolysis under oxidative anodic conditions. Here, the authors report that electrochemical oxidation dominates ionomer cations degradationand that oxidation-resistant trimethylammonium ionomers enable long-term durability.

The authors report ambient-pressure, polarization-resolved electronic Raman scattering measurements on single crystals of nickelate La₃Ni₂O₇, which becomes superconducting under pressure. Quantitative analysis reveals momentum-selective spin density wave (SDW) gap amplitudes, indicating an unconventional SDW driven by anisotropic electronic correlations.

Most atmospheric water harvesters suffer from slow sorption and intermittent solar-driven desorption. Here, the authors develop a hybrid wood composite with a phase change material that stores solar heat. It rapidly captures water across a wide humidity range and releases it continuously, even in darkness, achieving a daily yield of 0.96–1.72 L kg⁻¹.

The poor understanding of allosteric binding site hinders further development of cannabinoid receptor CB2 allosteric modulators. Here, authors report the cryo-EM structure of CB2in complex with ligands and elucidate the structural basis for the function of positive allosteric modulator Ec21a.

Realising the potential of DNA nanomaterials for biomedical applications requires efficient manufacturing approaches. Here the authors develop a scalable bacteriophage-based method to directly produce stable, reproducible DNA nanoassemblies with minimal purification, enabling low-cost production.

Changhua County, Taiwan launched a hepatitis C elimination initiative which integrates population-based screening and targeted strategies for high-risk groups. Here, the authors evaluate its impacts on hepatitis C virus cascade care and treatment outcomes and compare to a counterfactual scenario without the program.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Btg2 suppresses UFMylation of Fmo1, promoting its k48-linked ubiquitination and degradation, thereby restricting taurine synthesis and exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury.

The authors report superconducting diode effect (SDE) at zero magnetic field in flakes and micro bridges of kagome CsV₃Sb₅, consistent with spontaneous time-reversal symmetry (TRS) breaking. They also demonstrate magnetic-field training, implying that the charge-density-wave state itself breaks TRS.

Dysregulated CD59 drives uncontrolled complement activation in neuromyelitis optica spectrum disorders (NMOSD). Here, the authors show in a mouse NMOSD model that endothelial SPARC suppresses astrocytic CD59 by blocking the VEGFA/VEGFR2 axis, promoting astrocytopathy, that might offer a potential therapeutic strategy.

Structurally engineered graphene oxide membranes fabricated by heterogeneous co-assembly enable rapid, selective solvent dehydration through coupled water adsorption and diffusion in sp³ /sp² nanochannels, showing high flux with precise molecular sieving.

The trigger for magnetic reconnection in the Venusian magnetotail remains unclear. Here, the authors show that interplanetary shocks can effectively compress draped magnetic fields, driving magnetic reconnection at unmagnetized planets.

This work develops a 3D-printed aluminium alloy with an Al₃Er nanoscale skeleton that deforms rather than breaks, achieving 700 MPa strength and 7% elongation, the mechanisms of which enable stronger lightweight structural metals.

Dynamic encirclement of exceptional points (EPs) has so far been reported for chiral, direction dependent mode switching due to non-adiabatic transitions. Here, authors experimentally demonstrate EP encircling related to restored adiabaticity and symmetric state transfer, by modulating polarisation in a two-mode photonic platform.

TBC1D19 and KIAA1841 are subunits of the tubulin poly-glutamylase complex and essential for assembly of an active holo-enzyme. TBC1D19 also promotes assembly/stability of primary cilia and phosphoinositide homeostasis.

Tang et al. demonstrate that disease progression in Duchenne muscular dystrophy is driven not only by dystrophin deficiency but also by ANXA11-mediated failure of regenerative myofiber maturation. Targeting ANXA11 improves muscle regeneration and function in mdx mice.

Preeclampsia results from abnormal placentation, but the role of protein O-fucosylation is unclear. Here the authors show that poFUT1 loss reduces EDIL3 O-fucosylation, disrupts LIFR–STAT3 signaling, and causes defective placental remodeling and PE-like phenotypes.

Lei et al. demonstrate that a rhizobial effector NopZ is phosphorylated by a symbiotic receptor kinase, leading to its enrichment in the nuclear/perinuclear region and promoting soybean nodulation.

RNA-binding proteins (RBPs) regulate gene expression, but predicting RBP–RNA interactions across species is challenging. Here, the authors introduce MuSIC, a deep learning framework leveraging label smoothing and evolutionary conservation across 11 species to predict cross-species RBP–RNA interactions.

Ketogenic diet (KD) generates β-hydroxybutyrate metabolites and has been shown to have context-dependent immunomodulatory effects. However, the effects of KD on inflammatory bowel disease (IBD) are controversial. Here, the authors investigate the pathogenic effects of KD in a preclinical model of DSS-induced colitis and identify a β-HB-Thomasclavelia spiroformis-γδ17 T cell axis that exacerbates inflammation and mucosal damage.

Portal fibrosis, a hallmark of progression in chronic liver diseases, typically develops following biliary injury. This study identifies Clec3b⁺ fibroblasts as key drivers of liver portal fibrosis and demonstrates that a KLF4/periostin signaling axis controls their activation, highlighting potential therapeutic targets for inhibiting fibrosis in biliary diseases.

Idiopathic pulmonary fibrosis is a fatal lung disease driven by aberrant fibroblast activation, but the underlying metabolic changes remain unclear. Here, the authors show that dysregulated branched chain amino acid metabolism promotes lung fibrosis and can be therapeutically targeted.

AgBiS₂ nanocrystals show promise for thin, low-cost solar cells but are hindered by poor charge transport and limited infrared absorption. Yang et al. grow a molecular lead halide perovskite layer on the nanocrystals to passivate defects, improve transport, and enable highpower conversion efficiency.

Low-dose IL-2 therapy has been evaluated for the treatment of numerous autoimmune conditions. This study reports the outcomes of a phase 2, randomised, placebo-controlled trial evaluating the efficacy and safety of low-dose IL-2 for the treatment of systemic lupus erythematosus (SLE).

Poor storage stability and soil survival limits agricultural application of non-spore forming bacteria. Here, the authors develop a hydrogel microcapsule which improves storage and soil survival, demonstrating application in improving plant salt tolerance under field conditions.

Radiotherapy (RT) is standard-of-care in cancer management; however, RT efficacy remains limited. Here, the authors test whether membrane camouflaged BCG bacteria (MBCG) enhance response to RT in preclinical models of glioblastoma. MBCG efficiently targets tumor tissues, induces trained immunity in tumor-associated macrophages, and enhances the RT-induced anti-tumor responses.

Whilst it is known that host ribosomal protein SA (RPSA) regulates the anti-infection immunity in immune cells, its role in neutrophil migration is yet to be explored. In this work, authors provide mechanistic insight into the impact of RPSA on promoting neutrophil migration via the regulation of olfactomedin 4 (OLFM4), in the context of sepsis.

This study found that severe fever with thrombocytopenia syndrome increased in Anhui, China in 2019–2023 and was highest in central and southern areas. Farmers and older adults were most affected, peaking in spring to early autumn.

Previous work suggests that heterogeneous static networks hinder collective cooperation fixation. Here, the authors show that heterogeneous temporal networks outperform homogeneous ones by accelerating cooperative spread—an effect washed out in static cases.

UCl₃-type electrolytes show promise for all-solid-state batteries, yet their structure and Li⁺ transport remain debated. Here, authors reveal foreign cations reside in the amorphous phase, which serve as the dominant Li⁺ pathway yielding enhanced conductivity and low-temperature battery performance.

Poly(A) tails are critical to gene regulation, yet their organism-wide patterns remain unmapped. Here, the authors provide an 18-organ mouse atlas, revealing that poly(A) dynamics is fundamentally orthogonal to mRNA abundance.

Iron fluoride electrodes show contrasting stability in ether- and ester-based electrolytes. Here, the authors reveal that interfacial anion chemistry governs conversion pathways and phase evolution, explaining the origin of stability differences and guiding the design of high-energy lithium batteries.

Researchers developed ultralow-density rigid-network hydrogels for stable solar desalination under intense sunlight. They reach an evaporation rate of 25.57 kg m⁻² h⁻¹ at 10 suns and deliver water production of 138 L m⁻² day⁻¹ in low-cost modules.

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Researchers have found that extreme hot-wet weather in 2024 triggered a spike in ecosystem respiration, mainly in tropical non-forests, significantly reducing the year’s land carbon sink and pushing the atmospheric CO2 growth rate to a record high.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

To directly examine how burst-suppression emerges across large neuronal populations, here authors present a Cortex-wide Optical-electrical Dual-modal Explorer (CODE) system. This integrated optical–electrical recording system reveals how large-scale neuronal ensembles organize burst and suppression activity across the mouse cortex during anesthesia, uncovering coordinated dynamics underlying cortical state transitions.