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Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

Clemence Ngo
Camille Pierini-Malosse
Elena Tomasello
ResearchOpen Access29 Sept 2025
Nature Immunology

Volume: 26, P: 1962-1976
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

Kasper Hoebe
Edith M Janssen
Bruce Beutler
Research16 Nov 2003
Nature Immunology

Volume: 4, P: 1223-1229
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Tian Wang
Terrence Town
Richard A Flavell
Research21 Nov 2004
Nature Medicine

Volume: 10, P: 1366-1373
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

Lena Alexopoulou
Venetta Thomas
Richard A. Flavell
Research01 Jul 2002
Nature Medicine

Volume: 8, P: 878-884
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

Sandra S. Diebold
Maria Montoya
Caetano Reis e Sousa
Research22 Jun 2003
Nature

Volume: 424, P: 324-328
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou
Agnieszka Czopik Holt
Richard A. Flavell
Research18 Oct 2001
Nature

Volume: 413, P: 732-738
Toll-like receptor 3 promotes cross-priming to virus-infected cells

Oliver Schulz
Sandra S. Diebold
Caetano Reis e Sousa
Research13 Feb 2005
Nature

Volume: 433, P: 887-892
Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Sieweke and colleagues show that alveolar macrophages maintain a core gene expression program even after several months in culture and reacquire full transcriptional and epigenetic identity after transplantation into the lung.

Sethuraman Subramanian
Clara Jana-Lui Busch
Michael H. Sieweke
Research24 Feb 2022
Nature Immunology

Volume: 23, P: 458-468
Resurrection of endogenous retroviruses in antibody-deficient mice

Novel pathogenic infectious retroviruses, generated by recombination between replication-defective endogenous retroviruses in the absence of a functional antibody response, are identified; these recombinant retroviruses establish infection of mouse colonies and ultimately cause cancer.

George R. Young
Urszula Eksmond
George Kassiotis
Research24 Oct 2012
Nature

Volume: 491, P: 774-778

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Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Toll-like receptor 3 promotes cross-priming to virus-infected cells

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo

Resurrection of endogenous retroviruses in antibody-deficient mice

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