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The authors find that O-GalNAc transferase 2 (GALNT2) restricts viral infection, probably through the regulation of the proteolytic processing of viral glycoproteins via its O-linked glycosylation activity, impairing virus–cell fusion.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

Xu et al. reveal that a bottom-up neural circuit from the medial septum to the subfornical organ prevents overhydration in mice by integrating oral and gastrointestinal signals before osmolality changes, demonstrating precise drinking control mechanisms.

The authors propose a method for high-capacity information encoding and long-distance image transmission by utilising Hermite-Gaussian eigenmodes in defective states. The enables the generation over 10ⁿ varying laser states for encoding, or an information capacity of tens of bits.

Here, the authors show that GalNAc-T3 and T7 regulate furin cleavage of the SARS-CoV-2 spike protein via O-glycosylation. This influences viral assembly and infection, highlighting glycosylation as a host defense mechanism.

Here they identify a selective PRC1.1 inhibitor, iBP, that treats bone loss by improving osteoblast function. iBP releases repression of Wnt/β-catenin signaling, enhancing bone formation and repair in aging, trauma, and disease models.

It is challenging to maintain the CO selectivity under high current densities in CO₂ electro-reduction process. Here the authors report the synergistic interface between redox active CO₂ organic sorbents and defective Ag catalysts that can enable an ampere level CO₂-to-CO conversion.

The energy disorders in the lateral direction of the junction in large-area photovoltaic modules are largely overlooked. Here, authors employ organic amidinium passivators to suppress the micro-inhomogeneity in the lateral energy landscapes and achieve high performance stable perovskite solar cells.

Filtering capacitors are essential to smooth high voltage alternating current lines but are typically limited to hundreds of volts. Here, the authors demonstrate an aqueous hybrid electrochemical capacitor that can exhibit an operating voltage of 1,000 V when assembled into a device of 670 units.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

This study develops a liquid-gating topological gradient microfluidics device that generates finely tuned microbubbles in a functional liquid in a high-throughput manner for air purification in different scenarios.

MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

The partial replacement of the A-site by divalent methylenediammonium cations inhibits ion migration and photoinduced halide segregation in wide-bandgap perovskites. Single-junction devices achieve a certified power conversion efficiency of 22.71%, whereas perovskite/Cu(In,Ga)Se₂ tandem devices exhibit an efficiency of 30.13% in a four-terminal architecture.

Piezocapacitive pressure sensors are typically limited by the slow response-relaxation speed for detecting dynamic stimuli. Here, Zhang et al. utilize the electrode-dielectric interface and bonded micro-structured interface for energy dissipation and reduce the response and relaxation time to 0.04 ms.

Electrochemically-mediated carbon capture has good energy efficiency and potential in carbon dioxide separation, but optimisation of these systems is challenging. Here, the authors report the use of isoindigo derivatives to give fine-tuned interactions with CO₂ for carbon capture methods.

A HfNbTiVAl₁₀ alloy shows tensile ductility and ultrahigh yield strength from the addition of aluminium to a HfNbTiV alloy, resulting in a negative mixing enthalpy solid solution, which promotes strength and favours formation of hierarchical chemical fluctuations.

Zheng et al. generate and utilize a biobank of colorectal cancer PDOs to find that high LGR4 is linked to chemoresistance. They develop a monoclonal antibody against LGR4 that activates ferroptosis and is therapeutically beneficial.

E-skins often have poor interfaces that lead to unstable performances. Here, authors report e-skins with a quasi-homogeneous composition and bonded micro-structured interfaces, through which both the sensitivity and stability of the devices are improved.

The basic mechanisms behind the East Asian Summer Monsoon remain poorly understood. Using proxy-based reconstructions and simulations, here the authors show that changes in the orientation and position of the westerly jet stream resulted in regionally asynchronous Holocene precipitation maxima.

While most of the structural colored materials only present isotropic colors, limiting their functions and many practical applications, while realizing anisotropic structural color materials remains challenging. Here, the authors develop a freeze-derived heterogeneous structural color hydrogels for information encryption and decryption.

Here, the authors show that PDHE1α accumulates at DNA double-strand breaks, in a PARylation-dependent manner, where it locally supplies acetyl-CoA for histone acetylation. These events facilitate remodeling of the chromatin landscape and efficient repair.

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.