Nature Search

Generative AI for misalignment-resistant virtual staining to accelerate histopathology workflows

Ma, Li, and colleagues present a virtual tissue staining method that overcomes data mismatch by separating image generation from spatial alignment. This approach produces highly accurate diagnostic images that expert pathologists cannot distinguish from real chemical stains.

Jiabo Ma
Wenqiang Li
Hao Chen
ResearchOpen Access27 Mar 2026
Nature Communications

P: 1-14
Engineering programmable CAR and antigen pairing via drug-gated light activation

Solid-tumor CAR-T therapy is limited by antigen escape, heterogeneity, and on-target/off-tumor toxicity. The author here develops a drug-gated light-activatable, programmable CAR-antigen pairing system that enables flexible multi-antigen targeting with spatial control, achieving effective tumor suppression with minimal off-tumor toxicity.

Ziliang Huang
Praopim Limsakul
Yingxiao Wang
ResearchOpen Access19 Mar 2026
Nature Communications

P: 1-17
Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks

Bridging molecular to brain network organization is hindered by cross-individual data. Here, the authors show paired fMRI and spatial transcriptomics in awake mice via decoding that metabolic gene programs predict thalamic BOLD activation.

Changjiang Zhang
Yijuan Zou
Xiaoqun Wang
ResearchOpen Access18 Apr 2026
Nature Communications

P: 1-19
Domino effect of climate change over two millennia in ancient China’s Hexi Corridor

Social responses to changes can trigger further crises. This study uses historical data and finds society’s failures to respond to climate change in China’s Hexi Corridor amplified problems.

Qi Feng
Linshan Yang
Shixiong Cao
Research09 Oct 2019
Nature Sustainability

Volume: 2, P: 957-961
Ultrasound Control of Genomic Regulatory Toolboxes for Cancer Immunotherapy

There remains a critical need for precise control of CRISPR-based technologies. Here, the authors develop a focused ultrasound (FUS)-controllable CRISPR toolbox, allowing the noninvasive and spatiotemporal control of genomic/epigenomic reprogramming for cancer treatment combined with CAR-T therapy.

Yiqian Wu
Ziliang Huang
Yingxiao Wang
ResearchOpen Access01 Dec 2024
Nature Communications

Volume: 15, P: 1-16
A quantitative evaluation model of ancient military defense efficiency based on spatial strength—take Zhejiang of the Ming Dynasty as an example

Yinggang Wang
Lifeng Tan
Mengqi Mu
ResearchOpen Access28 Nov 2023
Heritage Science

Volume: 11, P: 1-13
Tumour priming by ultrasound mechanogenetics for CAR T therapy

A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour suppression at distinct sites.

Chi Woo Yoon
Chunyang Song
Yingxiao Wang
ResearchOpen Access31 Oct 2025
Nature Materials

Volume: 25, P: 310-321
Silicon-based all-solid-state batteries operating free from external pressure

Si-based all-solid-state batteries face application challenges due to the requirement of high external pressure. Here, authors prepare a double-layered Si-based electrode by cold-pressing and electrochemical sintering that enables all-solid-state batteries operating free from external pressure.

Zhiyong Zhang
Xiuli Zhang
Songyan Chen
ResearchOpen Access25 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Author Correction: Embedded nano spin sensor for in situ probing of gas adsorption inside porous organic frameworks

Jie Zhang
Linshan Liu
Taishan Wang
Amendments and CorrectionsOpen Access04 Sept 2023
Nature Communications

Volume: 14, P: 1
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

A ketogenic diet can reduce calorie absorption and protect against obesity by inducing changes to the gut microbiota and the bile acid pool.

Xiao Li
Jie Yang
Shangyu Hong
Research27 Jun 2024
Nature Metabolism

Volume: 6, P: 1397-1414
Molecular spin sensor for in-situ monitoring of crystallization behavior and phase transition in aromatic materials

Spin-active materials with sensitive electron spin centers have drawn significant attention in quantum sensing due to their unique quantum characteristics. Herein, the authors report a molecular spin sensor based on metallofullerene Y₂@C₇₉N for in-situ monitoring of crystallization behavior and phase transitions in aromatic materials with high precision.

Linshan Liu
Chong Zhao
Taishan Wang
ResearchOpen Access04 Aug 2025
Nature Communications

Volume: 16, P: 1-8
Control of the activity of CAR-T cells within tumours via focused ultrasound

The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.

Yiqian Wu
Yahan Liu
Yingxiao Wang
Research12 Aug 2021
Nature Biomedical Engineering

Volume: 5, P: 1336-1347
Embedded nano spin sensor for in situ probing of gas adsorption inside porous organic frameworks

Spin-based sensors have attracted attention due to their high sensitivities. Here authors present a fullerene-based nano spin sensor for in-situ sensing of gas adsorption in porous organic frameworks, demonstrating the potential applications of molecular spin systems in quantum sensing.

Jie Zhang
Linshan Liu
Taishan Wang
ResearchOpen Access15 Aug 2023
Nature Communications

Volume: 14, P: 1-10
A global strategy to mitigate the environmental impact of China’s ruminant consumption boom

Rising demand for ruminant meat and dairy products in developing nations drives increasing GHG and ammonia emissions from livestock. Authors show here that only long-term adoption of global best-practice in sustainable intensification buffered by a short-term coping strategy of green-source trading can offer a way forward.

Yuanyuan Du
Ying Ge
Raphael K. Didham
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-11
Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells

Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.

Qin Peng
Ziliang Huang
Yingxiao Wang
ResearchOpen Access24 Dec 2022
Nature Communications

Volume: 13, P: 1-15
Persistent stratospheric cold-season aerosols from the 1783 Laki eruption produced winter warming over Northern Eurasia

The 1783 Laki eruption triggered Northern Eurasia tropospheric winter warming due to a persistent cold-season stratospheric aerosol cloud. Climate model simulations, accounting for the multi-episode nature of the eruption, were validated by observational reconstructions of the climate response.

Linshan Yang
Chaochao Gao
Deliang Chen
ResearchOpen Access14 Jan 2026
Communications Earth & Environment

Volume: 7, P: 1-10
Anlotinib mediates intrinsic drug resistance in hepatoblastoma through the GAD1/GABA pathway

Haijin Huang
Yanping Feng
Haijin Liu
Research15 May 2025
Pediatric Research

Volume: 99, P: 339-350
Knowledge, attitudes, and practices of oxygen therapy among emergency nurses

Yazhu Zhao
Linshan Li
Wei Zhang
ResearchOpen Access30 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Prior knowledge-guided multimodal deep learning system for biomarker exploration and prognosis prediction of urothelial carcinoma

Quanhao He
Hao Tan
Mingzhao Xiao
ResearchOpen Access26 Dec 2025
npj Digital Medicine

Volume: 9, P: 1-17
Evaluation of Chinese traditional military settlements’ defensive capabilities via principal component analysis (PCA): a case study of coastal Wei forts in the Ming dynasty

Jiayin Zhou
Yilin Jiang
Lingxin Meng
ResearchOpen Access26 Mar 2024
Heritage Science

Volume: 12, P: 1-16
Prognosis and influencing factors of ER-positive, HER2-low breast cancer patients with residual disease after neoadjuvant chemotherapy: a retrospective study

Lingfeng Tang
Linshan Jiang
Shengchun Liu
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-10
MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7

Linshan Yang
Bo Wang
Zhenzhen Zhan
ResearchOpen Access10 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-14
Studies on adaptive capacity to climate change: a synthesis of changing concepts, dimensions, and indicators

Prem Sagar Chapagain
Tibendra Raj Banskota
Khagendra Raj Poudel
ReviewsOpen Access06 Mar 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-10
G protein-coupled receptors: structure- and function-based drug discovery

Dehua Yang
Qingtong Zhou
Ming-Wei Wang
ReviewsOpen Access08 Jan 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-27

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