Nature Search

Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Dalong Zhu
Weimin Wang
Hai Pan
ResearchOpen Access07 Jan 2026
Nature Communications

P: 1-10
Temporal anti-parity–time symmetry in diffusive transport

Applying concepts from non-Hermitian physics to diffusive systems enables the static control of heat transport. Now, this notion is expanded to dynamic control, including a demonstration of programmed thermal transport in a metamaterial.

Peng Jin
Chengmeng Wang
Jiping Huang
Research10 Dec 2025
Nature Physics

P: 1-7
Preventive conservation engineering practice based on deformation resistance capacity evaluation of heritage buildings

Guangbin Wang
Qiqun Li
Liujun Yang
ResearchOpen Access17 Nov 2025
Scientific Reports

Volume: 15, P: 1-17
Productive engagement patterns and their association with life satisfaction among elderly sandwich generation

Yang Yu
Liujun Yu
ResearchOpen Access24 Oct 2025
Scientific Reports

Volume: 15, P: 1-12
Free-form and multi-physical metamaterials with forward conformality-assisted tracing

Here a conformality-assisted tracing method is proposed to devise free-form and three-dimensional conformal metamaterials, featuring accuracy and efficiency in handling complex geometry and adaptability to various diffusion and wave fields.

Liujun Xu
Gaole Dai
Cheng-Wei Qiu
Research09 Jul 2024
Nature Computational Science

Volume: 4, P: 532-541
Author Correction: π-HuB: the proteomic navigator of the human body

Fuchu He
Ruedi Aebersold
Zemin Zhang
Amendments and Corrections23 Dec 2024
Nature

Volume: 637, P: E22
Increased plant productivity exacerbates subsoil carbon losses under warming via nitrogen mining

Soils may release more CO₂ under warming when increases in plant productivity mine nitrogen from soil organic matter, according to an analysis of a global dataset of soil organic carbon measurements.

Mingming Wang
Shuai Zhang
Zhongkui Luo
Research07 May 2025
Nature Geoscience

Volume: 18, P: 510-517
Asymmetric photooxidation of glycerol to hydroxypyruvic acid over Rb–Ir catalytic pairs on poly(heptazine imides)

The authors present a photocatalytic method to selectively oxidize glycerol to hydroxypyruvic acid over rubidium–iridium catalytic pairs on poly(heptazine imides) under visible-light illumination.

Zhenyuan Teng
Zhenzong Zhang
Bin Liu
Research31 Mar 2025
Nature Nanotechnology

Volume: 20, P: 815-824
T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

Jinmin Tian
Bingli Shang
Jun Liu
Research28 Jan 2025
Nature Immunology

Volume: 26, P: 265-278
Responses of soil organic carbon to climate extremes under warming across global biomes

Warming temperatures associated with climate change are expected to impact soil carbon stocks, yet the effect of more frequent and intense extreme climate events on soil carbon is yet unclear. This study shows that most extremes enhance soil carbon loss globally, with variation across ecosystems.

Mingming Wang
Shuai Zhang
Zhongkui Luo
Research22 Dec 2023
Nature Climate Change

Volume: 14, P: 98-105
Exploitation of heterosis loci for yield and yield components in rice using chromosome segment substitution lines

Yajun Tao
Jinyan Zhu
Guohua Liang
ResearchOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Global soil profiles indicate depth-dependent soil carbon losses under a warmer climate

The response of soil organic carbon to climate warming may be soil depth-dependent, but remains unquantified in situ. Here the authors show that warming induces more proportional soil carbon losses in topsoil than in subsoil, particularly from high-latitudinal carbon-rich soils.

Mingming Wang
Xiaowei Guo
Zhongkui Luo
ResearchOpen Access20 Sept 2022
Nature Communications

Volume: 13, P: 1-11
Identification of ferredoxin PA1551 as an antibacterial synergistic target for biofilm inhibitors against Pseudomonas aeruginosa

Jun Liu
Anmin Ren
Weimin Chen
ResearchOpen Access05 Dec 2025
npj Biofilms and Microbiomes

Volume: 12, P: 1-16
π-HuB: the proteomic navigator of the human body

We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human biology.

Fuchu He
Ruedi Aebersold
Zemin Zhang
Reviews11 Dec 2024
Nature

Volume: 636, P: 322-331
Towards unmanned proteomics data generation: a fully automated sample-to-data system for proteomic experiments

Dongxue Wang
Wendong Chen
Fuchu He
CorrespondenceOpen Access29 Oct 2025
Cell Discovery

Volume: 11, P: 1-4
Surveillance of SARS-CoV-2 at the Huanan Seafood Market

A study presents the results of surveillance for SARS-CoV-2 in animal and environmental samples from a market linked to early human cases of coronavirus disease 2019.

William J. Liu
Peipei Liu
Guizhen Wu
Research05 Apr 2023
Nature

Volume: 631, P: 402-408
Transcriptome reanalysis and gene expression of 13 detoxification genes for avermectin and pyridaben resistance in Panonychus citri

Xiaoqing Han
Mengyuan Peng
Chongbin Sun
ResearchOpen Access28 Oct 2024
Scientific Reports

Volume: 14, P: 1-13
Postoperative autotransfusion drain after total hip arthroplasty: a meta-analysis of randomized controlled trials

Hui Xie
Jian-Ke Pan
Jun Liu
ResearchOpen Access01 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury

Jialing Peng
Yuxin Huang
Jun Liu
Research21 May 2025
Cell Death & Differentiation

Volume: 32, P: 2160-2174
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Xin Wang
Jie Zhang
Jun Liu
ResearchOpen Access12 Jun 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-15
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

Penghui Yang
Yingze Zhao
Hai-Xi Sun
Correspondence26 Feb 2021
Cellular & Molecular Immunology

Volume: 18, P: 1064-1066

Search

Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial

Temporal anti-parity–time symmetry in diffusive transport

Preventive conservation engineering practice based on deformation resistance capacity evaluation of heritage buildings

Productive engagement patterns and their association with life satisfaction among elderly sandwich generation

Free-form and multi-physical metamaterials with forward conformality-assisted tracing

Author Correction: π-HuB: the proteomic navigator of the human body

Increased plant productivity exacerbates subsoil carbon losses under warming via nitrogen mining

Asymmetric photooxidation of glycerol to hydroxypyruvic acid over Rb–Ir catalytic pairs on poly(heptazine imides)

T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots

Responses of soil organic carbon to climate extremes under warming across global biomes

Exploitation of heterosis loci for yield and yield components in rice using chromosome segment substitution lines

Global soil profiles indicate depth-dependent soil carbon losses under a warmer climate

Identification of ferredoxin PA1551 as an antibacterial synergistic target for biofilm inhibitors against Pseudomonas aeruginosa

π-HuB: the proteomic navigator of the human body

Towards unmanned proteomics data generation: a fully automated sample-to-data system for proteomic experiments

Surveillance of SARS-CoV-2 at the Huanan Seafood Market

Transcriptome reanalysis and gene expression of 13 detoxification genes for avermectin and pyridaben resistance in Panonychus citri

Postoperative autotransfusion drain after total hip arthroplasty: a meta-analysis of randomized controlled trials

NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury

Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents

Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients

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