Nature Search

INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates

A chromosome-level Bactrian camel genome and multi-omics comparisons reveal adaptive evolution and convergent selection in desert ungulates, highlighting lipid/sterol metabolism—especially INSIG1—as a key driver of metabolic flexibility for desert survival.

Xinmei Li
Ziyi He
Yu Wang
ResearchOpen Access12 Jan 2026
Communications Biology

P: 1-16
OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice

Fang et al. demonstrate that OsHSFA4d enhances thermotolerance by activating HSP101 and promoting CslF6 expression, which suppresses disease resistance. It is phosphorylated by OsCDPK24/28, increasing its DNA binding ability under heat stress. This trade-off mechanism of abiotic/biotic stress may broadly exist in plant kingdom.

Yu Fang
Haicheng Liao
Xuewei Chen
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-19
How the extra X chromosome impairs the development of male fetal germ cells

In Klinefelter syndrome, gene dysregulation due to the extra X chromosome leads to delayed development of fetal germ cells (FGCs), and aberrant interactions between Sertoli cells and FGCs disrupt the migration of late FGCs to the basement membrane.

Yongjie Lu
Meng Qin
Jie Qiao
Research30 Oct 2024
Nature

Volume: 635, P: 960-968
Characteristics of heavy metal element content and health risk assessment in groundwater in Zhaojue area, Sichuan Province, China

Yongsheng Lin
Jinhui Liu
Li Lu
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-14
Correction: Corrigendum: Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I_h

Yuan Fan
Desdemona Fricker
Daniel Johnston
Amendments and Corrections01 Jan 2006
Nature Neuroscience

Volume: 9, P: 147
Discursive representations of sexual minorities in China’s English-language news media: a corpus-based study

Ke Zhang
Huibin Zhuang
Jingyuan Zhang
ResearchOpen Access03 Nov 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-11
Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

Using healthy mitochondria to restore impaired mitochondrial homeostasis is a promising therapy for pulmonary fibrosis. Here the authors use joint-engineered mesenchymal stem cells for efficient mitochondrial delivery to injured lung cells, showing a successful mitigation of the disease.

Ting Huang
Ruyi Lin
Jianqing Gao
ResearchOpen Access18 Sept 2023
Nature Communications

Volume: 14, P: 1-15
A vaccine targeting resistant tumours by dual T cell plus NK cell attack

A vaccine targeting stress proteins expressed by many cancers blocks a tumour escape mechanism, enabling protective immunity mediated by diverse T cell and NK cell populations.

Soumya Badrinath
Maxence O. Dellacherie
Kai W. Wucherpfennig
Research25 May 2022
Nature

Volume: 606, P: 992-998
Adiponectin is negatively associated with disease activity and Sharp score in treatment-naïve Han Chinese rheumatoid arthritis patients

Xixi Chen
Kaiwen Wang
Qiao Zhou
ResearchOpen Access08 Feb 2022
Scientific Reports

Volume: 12, P: 1-7
Mutational analysis of PRNP in Alzheimer’s disease and frontotemporal dementia in China

Weiwei Zhang
Bin Jiao
Lu Shen
ResearchOpen Access02 Dec 2016
Scientific Reports

Volume: 6, P: 1-7
Electrical manipulation and detection of antiferromagnetism in magnetic tunnel junctions

Antiferromagnetism of the IrMn layer in Pt/IrMn/CoFeB/MgO/CoFeB three-terminal magnetic tunnel junctions can be electrically detected using tunnelling magnetoresistance and controlled by a spin–orbit torque generated by a 0.8 ns current pulse applied across the heavy-metal platinum layer.

Ao Du
Daoqian Zhu
Weisheng Zhao
Research12 Jun 2023
Nature Electronics

Volume: 6, P: 425-433
Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation

TGF-β can function to increase Treg cell function and reduce anti-tumour immunity. Here the authors show that UDCA is a potential mediator that can reduce TGF-β activity and promote anti-tumour immune responses in mice and can be additive to other checkpoint inhibitors.

Yingying Shen
Chaojie Lu
Zhijian Cai
ResearchOpen Access14 Jun 2022
Nature Communications

Volume: 13, P: 1-14
Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I_h

Yuan Fan
Desdemona Fricker
Daniel Johnston
Research23 Oct 2005
Nature Neuroscience

Volume: 8, P: 1542-1551
A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Xixi Guo
Xiaosa Zhao
Jiandong Jiang
ResearchOpen Access08 Jul 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-18
Comparative genetic characterization of Enteroaggregative Escherichia coli strains recovered from clinical and non-clinical settings

Rong Zhang
Dan-xia Gu
Sheng Chen
ResearchOpen Access11 Apr 2016
Scientific Reports

Volume: 6, P: 1-9
ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population

Jinghua Wang
Chengfu Xu
Youming Li
ResearchOpen Access16 Nov 2015
Scientific Reports

Volume: 5, P: 1-10
Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H₂O₂

Haicheng Liao
Yu Fang
Xuewei Chen
ResearchOpen Access14 Jan 2025
Cell Research

Volume: 35, P: 205-219
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution

Li Li
Lin Li
Fuchou Tang
ResearchOpen Access03 Sept 2020
Cell Research

Volume: 31, P: 463-477
High Mountain Asia hydropower systems threatened by climate-driven landscape instability

Climate change is exacerbating geohazards in High Mountain Asia that pose a growing risk to hydropower and water infrastructure across the region.

Dongfeng Li
Xixi Lu
Tobias Bolch
Reviews23 Jun 2022
Nature Geoscience

Volume: 15, P: 520-530
Warming-driven erosion and sediment transport in cold regions

Anthropogenic warming is causing cryosphere degradation, which is increasing erosion and sediment transport. This Review describes changes in sediment fluxes and explains how peak sediment will be reached as a result of deglaciation and permafrost thaw.

Ting Zhang
Dongfeng Li
Xixi Lu
Reviews01 Nov 2022
Nature Reviews Earth & Environment

Volume: 3, P: 832-851
Comparative transcriptome analyses of different orthosiphon aristatus tissues reveal differentially expressed genes associated with flavonoid biosynthesis

Qiaoxue Wang
Huan Long
Shanyong Yi
ResearchOpen Access07 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Associations of risk genes with onset age and plasma biomarkers of Alzheimer’s disease: a large case–control study in mainland China

Bin Jiao
Xuewen Xiao
Lu Shen
Research09 Jan 2022
Neuropsychopharmacology

Volume: 47, P: 1121-1127
Discovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation

En Gao
Ya Wang
Shouhu Li
ResearchOpen Access22 Apr 2024
Scientific Reports

Volume: 14, P: 1-13
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages

Shuang Li
Dongyang Guo
Tianhua Zhou
ResearchOpen Access17 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 457-469
Anthropogenic eutrophication and stratification strength control hypoxia in the Yangtze Estuary

The severity of hypoxia in the Yangtze Estuary has increased in the last 50 years due to anthropogenic eutrophication and may be further exacerbated by climate-driven strengthening of stratification in the future, suggests sediment core analysis and climate modelling.

Hui Sheng
Stephen E. Darby
Ya Ping Wang
ResearchOpen Access04 May 2024
Communications Earth & Environment

Volume: 5, P: 1-10
m⁶Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation

Wei Zhuo
Meng Sun
Tianhua Zhou
ResearchOpen Access21 May 2022
Cell Discovery

Volume: 8, P: 1-17
The performance of a deep learning system in assisting junior ophthalmologists in diagnosing 13 major fundus diseases: a prospective multi-center clinical trial

Bing Li
Huan Chen
Youxin Chen
ResearchOpen Access11 Jan 2024
npj Digital Medicine

Volume: 7, P: 1-11
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Bin Zhang
Jie Li
Kunyu Yang
ResearchOpen Access29 Jan 2024
Cell Death & Differentiation

Volume: 31, P: 309-321
Substantial role of check dams in sediment trapping and carbon sequestration on the Chinese Loess Plateau

Check dams on the Chinese Loess Plateau are estimated to trap and bury approximately 10.2 ± 0.6 Pg of eroded sediment and 21.6 ± 9.9 Tg of organic carbon over the past 50 years, according to large-scale field surveys and remote sensing.

Nufang Fang
Yi Zeng
Zhihua Shi
ResearchOpen Access09 Mar 2023
Communications Earth & Environment

Volume: 4, P: 1-10
PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis

Yu He
Xixi Wang
Shufang Liang
ResearchOpen Access04 Feb 2022
Cell Death & Disease

Volume: 13, P: 1-15
Assessment of vegetation growth and drought conditions using satellite-based vegetation health indices in Jing-Jin-Ji region of China

Rengui Jiang
Jichao Liang
Fawen Li
ResearchOpen Access02 Jul 2021
Scientific Reports

Volume: 11, P: 1-18
Greenhouse gas emissions from the water–air interface of a grassland river: a case study of the Xilin River

Xue Hao
Yu Ruihong
Gao Ruizhong
ResearchOpen Access29 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Effective soil erosion control represents a significant net carbon sequestration

Lishan Ran
Xixi Lu
Xiankun Yang
ResearchOpen Access13 Aug 2018
Scientific Reports

Volume: 8, P: 1-8
A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression

Jialin Dai
Chonghe Zhang
Junhao Hu
ResearchOpen Access24 Apr 2020
Cell Death & Disease

Volume: 11, P: 1-16
3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors

Yajing Fang
Yulin Lu
Xiaoyun Xu
ResearchOpen Access06 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Drastic change in China's lakes and reservoirs over the past decades

Xiankun Yang
Xixi Lu
ResearchOpen Access13 Aug 2014
Scientific Reports

Volume: 4, P: 1-10
Heterogeneity and tumoral origin of medulloblastoma in the single-cell era

Hui Sheng
Haotai Li
Liguo Zhang
ReviewsOpen Access14 Feb 2024
Oncogene

Volume: 43, P: 839-850

Search

INSIG1 parallel substitution drives lipid/sterol metabolic plasticity mediating desert adaptation in ungulates

OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice

How the extra X chromosome impairs the development of male fetal germ cells

Characteristics of heavy metal element content and health risk assessment in groundwater in Zhaojue area, Sichuan Province, China

Correction: Corrigendum: Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I_h

Discursive representations of sexual minorities in China’s English-language news media: a corpus-based study

Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis

A vaccine targeting resistant tumours by dual T cell plus NK cell attack

Adiponectin is negatively associated with disease activity and Sharp score in treatment-naïve Han Chinese rheumatoid arthritis patients

Mutational analysis of PRNP in Alzheimer’s disease and frontotemporal dementia in China

Electrical manipulation and detection of antiferromagnetism in magnetic tunnel junctions

Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation

Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I_h

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Comparative genetic characterization of Enteroaggregative Escherichia coli strains recovered from clinical and non-clinical settings

ZJU index: a novel model for predicting nonalcoholic fatty liver disease in a Chinese population

Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H₂O₂

Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution

High Mountain Asia hydropower systems threatened by climate-driven landscape instability

Warming-driven erosion and sediment transport in cold regions

Comparative transcriptome analyses of different orthosiphon aristatus tissues reveal differentially expressed genes associated with flavonoid biosynthesis

Associations of risk genes with onset age and plasma biomarkers of Alzheimer’s disease: a large case–control study in mainland China

Discovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation

MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages

Anthropogenic eutrophication and stratification strength control hypoxia in the Yangtze Estuary

m⁶Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation

The performance of a deep learning system in assisting junior ophthalmologists in diagnosing 13 major fundus diseases: a prospective multi-center clinical trial

Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis

Substantial role of check dams in sediment trapping and carbon sequestration on the Chinese Loess Plateau

PGK1 contributes to tumorigenesis and sorafenib resistance of renal clear cell carcinoma via activating CXCR4/ERK signaling pathway and accelerating glycolysis

Assessment of vegetation growth and drought conditions using satellite-based vegetation health indices in Jing-Jin-Ji region of China

Greenhouse gas emissions from the water–air interface of a grassland river: a case study of the Xilin River

Effective soil erosion control represents a significant net carbon sequestration

A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression

3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors

Drastic change in China's lakes and reservoirs over the past decades

Heterogeneity and tumoral origin of medulloblastoma in the single-cell era

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