Search

Large-scale structural genomics and genome-wide association studies generate a wealth of data relevant to human disease. Wang et al. interpret these data in the context of a protein interaction network, showing that systematic analyses of the structural interfaces hit by mutations yield insights into pathogenesis.

Here they show that the E3 ubiquitin ligase CTLH supports mTORC1. Upon CTLH inactivation, ZMYND19 and MKLN19 accumulate, associate, and block mTORC1/RHEB association. CTLH and PI3K inhibition are synthetic lethal for EBV-associated gastric cancer.

Activity recognition in live-cell imaging is laborious. Here, authors present, IVEA, a fully automated AI ImageJ plugin, that efficiently detects and classifies exocytosis events, from synaptic transmission to single-vesicle fusion, across cell types and imaging setups.

Weyl semimetals are interesting because they are characterized by topological invariants, but specific examples discovered to date tend to have complicated band structures with many Weyl points. Here, the authors show that TaIrTe₄ has only four Weyl points, the minimal number required by time-reversal symmetry.

The dynamical axion quasiparticle, which is directly analogous to the hypothetical fundamental axion particle, is observed in two-dimensional MnBi₂Te₄, and has implications for quantum chromodynamics, cosmology and string theory.

Proposals for the realization of Weyl semimetals, topologically non-trivial materials which host Weyl fermion quasiparticles, have faced demanding experimental requirements. Here, the authors predict such a state in stoichiometric TaAs, arising due to the breaking of inversion symmetry.

Experimental measurements of high-order out-of-time-order correlators on a superconducting quantum processor show that these correlators remain highly sensitive to the quantum many-body dynamics in quantum computers at long timescales.

Electron distributions exhibit velocity-space signatures indicative of the rapid energy released by magnetic reconnection explosions occurring in Earth’s magnetosphere and in plasmas throughout the universe. Here, the authors discover a smile-shaped signature in the electron gradient distribution associated with reconnection occurring at Earth’s dayside magnetopause boundary.

B-cell depletion benefits systemic sclerosis, but predictive biomarkers remain limited. The authors here map autoantibody profiles using proteome-wide screening, identify C-C motif chemokine receptor 8-targeting autoantibodies with functional impact, suggesting novel pathophysiology and precision therapy targets.

A unified framework is presented that integrates observed spatial patterns of individual trees in forests with ecological processes into a novel coexistence theory.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Magic state distillation is achieved with logical qubits on a neutral-atom quantum computer using a dynamically reconfigurable architecture for parallel quantum operations.

A parallel experimental and computational approach was used to predict and prepare intercalated, layered hybrid perovskites, highlighting the breadth and flexibility of intercalation.

Causality, the relationship between cause and effect, is a central concept in Einstein’s theory of relativity. Here, authors show that a causality analogue in energy-momentum space plays an important role in describing quasiparticle interactions in quantum matter.

Spectroscopic signatures of magnetic response in topological materials remain very limited. Here, the authors observe a quasi-linear field dependent transverse magnetization and a non-saturating parallel magnetization in a Weyl semimetal TaAs under strong magnetic field, suggesting a signature of relativistic quasiparticles in topological materials.

What happens to correlated electronic phases—superconductivity and charge density wave ordering—as a material is thinned? Experiments show that both can remain intact in just a single layer of niobium diselenide.

Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

The nature of non-saturating magnetoresistance (MR) in topological materials is an important issue in condensed matter research but remains elusive. The authors here report the nonlinear MR at room temperature in WTe₂ with temperature-driven inversion due to the temperature-induced changes in Fermi surface convexity.

A large spin Hall angle and long spin diffusion length are found in the low-symmetry, few-layer semimetal MoTe₂ at room temperature, thus identifying this material as an excellent candidate for simultaneous spin generation, transport and detection.

Transition metal dichalcogenides exhibit diverse and tunable electronic states. Here the authors reveal a cascade of phase transitions upon increasing hydrostatic pressure in the few-layer 1T’-WS₂, including a re-entrant superconducting phase emerging from a normal state exhibiting anomalous Hall effect.

Symmetry-breaking distortion on the surface of topological crystalline insulators imparts mass to Dirac electrons. The mass is shown to depend on the penetration depth of the surface states. Non-topological surface states are also reported.

A superconducting material containing a topologically non-trivial electronic band structure presents the possibility of realizing Majorana states as well as exotic excitations with potential in quantum computing. Here, the authors evidence the required ingredients in the noncentrosymmetric superconductor BiPd.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

The power of quantum machine learning algorithms based on parametrised quantum circuits are still not fully understood. Here, the authors report rigorous bounds on the generalisation error in variational QML, confirming how known implementable models generalize well from an efficient amount of training data.

Here, Chen et. al. characterize the relationship between the gut microbiota and plasma metabolite changes in the context of ST-elevation myocardial infarction (STEMI), unveiling a role of butyrate-producing bacteria and their ketogenesis in post-STEMI cardiac repair, a finding validated in nonhuman primate and mouse models. They show that butyrate supplementation reduces myocardial infarction severity in mice, underscoring the significance of butyrate-producing bacteria and beta-hydroxybutyrate in improving post-MI outcomes.

Typical quantum error correcting codes assign fixed roles to the underlying physical qubits. Now the performance benefits of alternative, dynamic error correction schemes have been demonstrated on a superconducting quantum processor.

Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in type 2 alveolar epithelial (AT2) cells is thought to aggravate alveolar inflammation in acute lung injury. Here, the authors show that the mtLCFAO rate limiting enzyme CPT1a is decreased in AT2 cells in acute respiratory distress syndrome, highlighting the role of mtLCFAO in immunometabolism in this context.

Single-atomic impurities may induce novel quantum state, but they are unexplored in topological magnets. Here, the authors report spin-down polarized bound states which further interact with neighboring states to form spin-orbit split quantized orbitals in a topological magnet Co₃Sn₂S₂.

The molecular mechanisms ensuring early face, brain, and skin formation are unclear. Here, the authors uncover a posttranslational pathway that controls cytoskeletal signaling circuits to coordinate ectodermal patterning and neurulation.

Kramers–Weyl fermions are identified in chiral crystals, and their phenomenology is drawn out.

CCR5-deficient gamma–delta CD19 CAR T cells show resistance to HIV-mediated depletion and antitumour efficacy in B cell malignancies.

The authors present a multiomics study of type 2 diabetes and quantitative blood lipid and lipoprotein traits in Hispanic/Latino populations. They demonstrate how integrating GWAS with omics characterization can advance precision medicine.

Swanton and colleagues present a clonal expression signature, ORACLE, which, in combination with clinicopathological and molecular risk factors, can predict survival of patients with lung adenocarcinoma, and they prospectively validate its prognostic value.

Two Co single crystal surfaces remain metallic up to 1 bar during Fischer-Tropsch synthesis. The observed intermediates support the carbide mechanism as the reaction pathway. By adding and removing CO we can follow the dynamics of the (dis)appearance of intermediates.

Scanning tunnelling microscopy is used to reveal a new topological kagome magnet with an intrinsic Chern quantum phase, which shows a distinct Landau fan structure with a large Chern gap.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

This study challenges the long-standing assumption that some lunar samples are pristine, revealing pervasive impact modification. Using Al-in-zircon geochemistry, we demonstrate that key lunar rock fragments are not primary magmatic products, raising fundamental questions about the accuracy of lunar evolution models and the very records used to reconstruct the Moon’s history.

The search for magnetic Weyl fermion remains a challenge. Here, the authors report angle-resolved photoemission spectroscopy and magnetotransport measurements resolving the topological properties of Weyl fermion quasiparticles in magnetic non-centrosymmetric crystal PrAlGe.

Genome-wide analyses in over one million self-reported cases and controls identify genetic variants associated with stuttering and find genetic correlations with autism, depression and impaired musical rhythm, supporting a potential neurological basis for stuttering.

A Type II Weyl fermion semimetal has been predicted in Mo_xW_1−xTe₂, but it awaits experimental evidence. Here, Belopolski et al. observe a topological Fermi arc in Mo_xW_1−xTe₂, showing it originates from a Type II Weyl fermion and offering a new platform to study novel transport phenomena in Weyl semimetals.

The UCLA Ribonomics group reports that the nuclear export efficiency of innate immune mRNAs varies over a hundred-fold range such that for many genes only a small fraction of the newly synthesized premRNA reaches the cytoplasm. They show that nuclear export and cytoplasmic decay rates are correlated thereby ensuring similar expression levels of short-lived and long-lived mRNAs.

Experiments show that niobium arsenide is a Weyl semimetal.

Most mammalian TAD boundaries, which separate functional chromosomal domains, bind the CTCF protein. Here, the authors identify multi-level clustering of CTCF binding sites at TAD boundaries and confirm their individual contribution to TAD formation.

In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.

Two-dimensional materials provide possible platforms to map exotic phenomena from particle physics to condensed matter physics. Here, the authors predict doping dependent electronic behaviour in Mo_xW_1−xTe₂, in resemblance of a phenomenon which is believed to exist only in particle physics.