Chen et al. determined the cryo-EM structure of the TraT exclusion protein from the F plasmid of E. coli, revealing a unique hollow homodecameric architecture that includes α-helices traversing the outer membrane. Their work indicates that TraT might limit plasmid transfer via physical interference, offering insights into controlling antimicrobial resistance.
- Nicolas Chen
- Alfredas Bukys
- Ben C. Berks
