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Showing 1–50 of 53 results

Advanced filters: Author: Marc Schmitz Clear advanced filters

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia

Clonal haematopoiesis of indeterminate potential is driven by somatic mutations in hematopoietic stem/progenitor cells and may progress to myelodysplastic syndromes (MDS). Here authors show that the two conditions share a similar pattern of bone marrow remodeling, characterized by the emergence of inflammatory mesenchymal stromal cells and IFN-responsive T cells, reinforcing their shared etio-pathology.

Karin D. Prummel
Kevin Woods
Borhane Guezguez
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-25
The 51^st Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session (O008-O166)

Research Highlights05 Nov 2025
Bone Marrow Transplantation

Volume: 60, P: 19-182
The combined impact of fisheries and climate change on future carbon sequestration by oceanic macrofauna

Marine animals play a key role in locking carbon deep in the ocean, slowing climate change. This study finds that fishing has already cut this service in half, with climate change expected to further reduce it in the future.

Gaël Mariani
Jérôme Guiet
David Mouillot
ResearchOpen Access27 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Sex differences in oncogenic mutational processes

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Constance H. Li
Stephenie D. Prokopec
Christian von Mering
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-24
Contribution of epigenetic variation to adaptation in Arabidopsis

Whether plant epigenetic variation is subject to selection and contributes to adaptation is under debate. Here, the authors compare DNA methylation and phenotypes of Arabidopsis lines subject to simulated selection and their nearly isogenic ancestors and provide evidence that epigenetic variation contributes to adaptive responses.

Marc W. Schmid
Christian Heichinger
Ueli Grossniklaus
ResearchOpen Access25 Oct 2018
Nature Communications

Volume: 9, P: 1-12
Multimodal and spatially resolved profiling identifies distinct patterns of T cell infiltration in nodal B cell lymphoma entities

Roider, Baertsch et al. present a spatially resolved resource map of the T cell infiltration landscape across and within patients with distinct B cell non-Hodgkin lymphoma entities.

Tobias Roider
Marc A. Baertsch
Sascha Dietrich
ResearchOpen Access20 Feb 2024
Nature Cell Biology

Volume: 26, P: 478-489
Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathology

Whether Alzheimer’s disease originates in basal forebrain or entorhinal cortex remains highly debated. Here the authors use structural magnetic resonance data from a longitudinal sample of participants stratified by cerebrospinal biomarker and clinical diagnosis to show that tissue volume changes appear earlier in the basal forebrain than in the entorhinal cortex.

Taylor W. Schmitz
R. Nathan Spreng
Ansgar J. Furst
ResearchOpen Access04 Nov 2016
Nature Communications

Volume: 7, P: 1-13
A case report of sirolimus use in early fetal management of lymphatic malformation

Seront et al. report a case of successful management of high-risk cervicofacial fetal lymphatic malformations in utero via sirolimus taken orally by the mother from the 22nd week of pregnancy until 2 weeks before planned delivery.

Emmanuel Seront
Jean Marc Biard
Laurence M. Boon
Research01 Jun 2023
Nature Cardiovascular Research

Volume: 2, P: 595-599
Co-occurrence of memory impairment and fatigue distinguishes post COVID from pandemic-related health effects in the 4-year CON-VINCE cohort study

Patricia Martins Conde
Dmitry Bulaev
Victoria Lorentz
ResearchOpen Access27 Oct 2025
Scientific Reports

Volume: 15, P: 1-14
Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals

Historic smallpox vaccination and monkeypox virus (MPXV) infection elicit MPXV-neutralizing antibodies, but MPXV-neutralizing antibodies are less frequent and of lower magnitude after vaccination with MVA-BN—the vaccine approved and in use for protection against MPXV and smallpox.

Luca M. Zaeck
Mart M. Lamers
Rory D. de Vries
ResearchOpen Access18 Oct 2022
Nature Medicine

Volume: 29, P: 270-278
The antimicrobial potential of Streptomyces from insect microbiomes

Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.

Marc G. Chevrette
Caitlin M. Carlson
Cameron R. Currie
ResearchOpen Access31 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Hansen et al. compile and share an atlas of neurotransmitter receptor/transporter densities in the human cortex and show that receptor achitecture reflects brain structure, function, dynamics, cognitive specialization and disease vulnerability.

Justine Y. Hansen
Golia Shafiei
Bratislav Misic
ResearchOpen Access27 Oct 2022
Nature Neuroscience

Volume: 25, P: 1569-1581
Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

Cytotoxic T lymphocytes kill target cells through the fusion of lytic granules at the immunological synapse. Using high-resolution microscopy techniques Matti et al.identify synaptobrevin2 as the vesicular SNARE protein required for this fusion reaction.

Ulf Matti
Varsha Pattu
Jens Rettig
Research05 Feb 2013
Nature Communications

Volume: 4, P: 1-8
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis

Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response by termination of the phagosomal signalling of Dectin-1.

Torben Mentrup
Anna Yamina Stumpff-Niggemann
Bernd Schröder
ResearchOpen Access06 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Vaccines against the original strain of SARS-CoV-2 provide T cell memory to the B.1.1.529 variant

Dörnte et al. analyze whether T cell memory towards the B.1.1.529 spike protein of SARS-CoV-2 is retained in individuals vaccinated against the original Wuhan strain of SARS-CoV-2. CD4 and CD8 responses are slightly reduced compared to responses to the original spike protein.

Charlyn Dörnte
Verena Traska
Marc Schuster
ResearchOpen Access02 Nov 2022
Communications Medicine

Volume: 2, P: 1-6
Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4

Rudi Vennekens
Jenny Olausson
Marc Freichel
Research11 Feb 2007
Nature Immunology

Volume: 8, P: 312-320
Structures of the E. coli translating ribosome with SRP and its receptor and with the translocon

The co-translational insertion of proteins into membranes requires interaction between a ribosome-bound signal recognition particle (SRP) and a membrane-bound translocon. Here the authors use cryo-EM and single particle reconstructions to obtain a comprehensive view of the co-translational protein targeting process.

Ahmad Jomaa
Daniel Boehringer
Nenad Ban
ResearchOpen Access25 Jan 2016
Nature Communications

Volume: 7, P: 1-9
Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

T. Sunn Pedersen
M. Otte
Sandor Zoletnik
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-10
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T_H17 differentiation

Mutations in the RNA-binding protein roquin-1 are known to result in humoral autoimmunity. Heissmeyer and colleagues show that MALT1 cleavage of roquin and regnase-1 downstream of TCR signaling releases cooperatively repressed targets to promote T_H17 cell differentiation

Katharina M Jeltsch
Desheng Hu
Vigo Heissmeyer
Research05 Oct 2014
Nature Immunology

Volume: 15, P: 1079-1089
A blue light receptor that mediates RNA binding and translational regulation

A light-oxygen-voltage photoreceptor was found to bind short RNA stem loops in a light-dependent manner, which can be harnessed to regulate gene expression in bacteria and mammalian cells.

Anna M. Weber
Jennifer Kaiser
Andreas Möglich
Research26 Aug 2019
Nature Chemical Biology

Volume: 15, P: 1085-1092
Elevated hexosylceramides in Parkinson’s disease cause gene upregulations in neurons mimicking responses to pathogens

Luisa Franck
Lisa Hahnefeld
Irmgard Tegeder
ResearchOpen Access30 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-18
Author Correction: Codon-specific translation reprogramming promotes resistance to targeted therapy

Francesca Rapino
Sylvain Delaunay
Pierre Close
Amendments and Corrections11 Nov 2021
Nature

Volume: 599, P: E14
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Resistance to first line treatment is a major hurdle in cancer treatment, that can be overcome with drug combinations. Here, the authors provide a large drug combination screen across cancer cell lines to benchmark crowdsourced methods and to computationally predict drug synergies.

Michael P. Menden
Dennis Wang
Julio Saez-Rodriguez
ResearchOpen Access17 Jun 2019
Nature Communications

Volume: 10, P: 1-17
A high-throughput imaging and nuclear segmentation analysis protocol for cleared 3D culture models

Molly E. Boutin
Ty C. Voss
Marc Ferrer
ResearchOpen Access24 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
FOXO-dependent regulation of innate immune homeostasis

Antimicrobial peptides (AMPs) are an important class of immune effector molecules which fight pathogen infections. AMP induction in Drosophila is regulated through the activation of the Toll and immune deficiency pathways; it is now shown that AMP activation can be achieved independently of these pathways by the transcription factor FOXO. In non-infected animals, AMP genes are activated in response to nuclear FOXO activity when induced by starvation.

Thomas Becker
Gerrit Loch
Michael Hoch
Research21 Jan 2010
Nature

Volume: 463, P: 369-373
Quantification of cellular adhesion molecules on malignant B cells from non-Hodgkin’s lymphoma

M-C Jacob
S Agrawal
J Plumas
Research09 Sept 1999
Leukemia

Volume: 13, P: 1428-1433
The complete structure of the large subunit of the mammalian mitochondrial ribosome

The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Å resolution, revealing the location of 50 ribosomal proteins, the peptidyl transferase centre, the tRNAs within this active site, and the nascent peptide chain within the exit tunnel.

Basil J. Greber
Daniel Boehringer
Nenad Ban
Research01 Oct 2014
Nature

Volume: 515, P: 283-286
Evaluating language model embeddings for Parkinson’s disease cohort harmonization using a novel manually curated variable mapping schema

Yasamin Salimi
Tim Adams
Martin Hofmann-Apitius
ResearchOpen Access20 Jun 2025
Scientific Reports

Volume: 15, P: 1-13
Clustering of Crohn's disease within affected sibships

Jean-Pierre Hugot
Jean-Pierre Cézard
J Belaiche
Research14 Feb 2003
European Journal of Human Genetics

Volume: 11, P: 179-184
A 5′-CG-3′-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues

Marc Munnes
Giovanna Patrone
Walter Doerfler
Research19 Oct 1998
Oncogene

Volume: 17, P: 2573-2583
Codon-specific translation reprogramming promotes resistance to targeted therapy

Enzymes that catalyse modifications of wobble uridine 34 tRNA are essential for the survival of melanoma cells that rely on HIF1α-dependent metabolism through codon-dependent regulation of the translation of HIF1A mRNA.

Francesca Rapino
Sylvain Delaunay
Pierre Close
Research20 Jun 2018
Nature

Volume: 558, P: 605-609
RevCAR-mediated T-cell response against PD-L1-expressing cells turns suppression into activation

Eugenia Crespo
Liliana R. Loureiro
Anja Feldmann
ResearchOpen Access09 Feb 2025
npj Precision Oncology

Volume: 9, P: 1-15
Estimating regional flood discharge during Palaeocene-Eocene global warming

Chen Chen
Laure Guerit
Sébastien Castelltort
ResearchOpen Access06 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition

Julia Fischer
Lisa Rusyn
Tamina Seeger-Nukpezah
ResearchOpen Access12 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-13
Ontogeny of MAP Kinases in Rat Small Intestine: Premature Stimulation by Insulin of BBM Hydrolases Is Regulated by ERKs but not by p-38 MAP Kinase

Soheila Marandi
Nadine De Keyser
Jean-Paul Buts
Research01 Aug 2002
Pediatric Research

Volume: 52, P: 180-188
Retest variability and patient reliability indices of quantitative fundus autofluorescence in age-related macular degeneration: a MACUSTAR study report

Leon von der Emde
Merten Mallwitz
Thomas Ach
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-12
Mutations in the splicing factor SF3B1 are linked to frequent emergence of HLA-DR^low/neg monocytes in lower-risk myelodysplastic neoplasms

Susann Winter
Marie Schneider
Shahram Kordasti
ResearchOpen Access17 Apr 2024
Leukemia

Volume: 38, P: 1427-1431
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
Unexpected genomic features in widespread intracellular bacteria: evidence for motility of marine chlamydiae

Astrid Collingro
Stephan Köstlbacher
Matthias Horn
ResearchOpen Access23 Jun 2017
The ISME Journal

Volume: 11, P: 2334-2344
Autonomic dysregulation in long-term patients suffering from Post-COVID-19 Syndrome assessed by heart rate variability

Frank C. Mooren
Irina Böckelmann
Boris Schmitz
ResearchOpen Access22 Sept 2023
Scientific Reports

Volume: 13, P: 1-11
Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer

Anne M Schultheis
Marc Bos
Hans-Ulrich Schildhaus
Research26 Jul 2013
Modern Pathology

Volume: 27, P: 214-221
Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Hans-Ulrich Schildhaus
Lukas C Heukamp
Reinhard Buettner
ResearchOpen Access08 Jun 2012
Modern Pathology

Volume: 25, P: 1473-1480
“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells

Nicola Mitwasi
Anja Feldmann
Michael Bachmann
ResearchOpen Access07 Feb 2020
Scientific Reports

Volume: 10, P: 1-16
High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor

Céline Galés
Didier Sanchez
Sandrine Silvente-Poirot
Research04 Sept 2003
Oncogene

Volume: 22, P: 6081-6089
Reliability and suitability of physiological exercise response and recovery markers

Thomas Reichel
Tim K. Boßlau
Karsten Krüger
ResearchOpen Access17 Jul 2020
Scientific Reports

Volume: 10, P: 1-11
Bortezomib significantly impairs the immunostimulatory capacity of human myeloid blood dendritic cells

C Straube
R Wehner
M Schmitz
Research10 May 2007
Leukemia

Volume: 21, P: 1464-1471
Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase

Hugo Mathé-Hubert
Dominique Colinet
Jean-Luc Gatti
ResearchOpen Access25 Oct 2016
Scientific Reports

Volume: 6, P: 1-17
Evoked and oscillatory EEG activity differentiates language discrimination in young monolingual and bilingual infants

Loreto Nacar Garcia
Carlos Guerrero-Mosquera
Nuria Sebastian-Galles
ResearchOpen Access09 Feb 2018
Scientific Reports

Volume: 8, P: 1-9
Age at onset as stratifier in idiopathic Parkinson’s disease – effect of ageing and polygenic risk score on clinical phenotypes

L. Pavelka
A. Rauschenberger
Paul Wilmes
ResearchOpen Access09 Aug 2022
npj Parkinson's Disease

Volume: 8, P: 1-10
The measured distance between tumor cells and the peritoneal surface predicts the risk of peritoneal metastases and offers an objective means to differentiate between pT3 and pT4a colon cancer

Emma S. Zwanenburg
Daniel D. Wisselink
Mandy Zournas
Research19 Sept 2022
Modern Pathology

Volume: 35, P: 1991-2001

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