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Showing 1–12 of 12 results
Advanced filters: Author: Marian Kalocsay Clear advanced filters

  • Lysosomes are vital for cellular health and linked to many diseases. Here, authors use cryo-ET to image intact lysosomes and resolve lysosomal protein structures, providing a platform to advance the study of lysosome biology.

    • Bridget M. McVeigh
    • José J. De Jesús-Pérez
    • Vera Y. Moiseenkova-Bell
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • An in vivo approach to identify proteins whose enrichment near cardiac CaV1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.

    • Guoxia Liu
    • Arianne Papa
    • Steven O. Marx
    Research
    Nature
    Volume: 577, P: 695-700

  • The discovery of a specific CDK12 bivalent degrader, BSJ-4-116, reveals that chronic exposure of MOLT-4 and Jurkat cells to BSJ-4-116 leads to acquired resistance to the compound via point mutations in the CDK12 kinase domain.

    • Baishan Jiang
    • Yang Gao
    • Nathanael S. Gray
    Research
    Nature Chemical Biology
    Volume: 17, P: 675-683

  • Papa et al. show that phosphorylation by PKA of four residues in Rad, a calcium channel inhibitor, is required to mediate the β-adrenergic-induced increase in calcium current and contractile force. Additionally, Rad-phosphosite-mutant mice showed reduced basal heart rate and contractility. Conversely, expression of mutant calcium channel unable to bind wild-type or phosphosite-mutant Rad was sufficient to enhance basal calcium influx and contractility, independently of β-adrenergic stimulation.

    • Arianne Papa
    • Sergey I. Zakharov
    • Steven O. Marx
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 1022-1038

  • Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al. show that BH3 mimetics, which inhibit pro-survival proteins BCL-2 or MCL-1, can effectively eliminate diseased cells.

    • Cameron S. Fraser
    • Johan K. E. Spetz
    • Kristopher A. Sarosiek
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • A set of enantioprobes—photoreactive, clickable fragment pairs differing only in absolute stereochemistry—have been used to provide a robust and streamlined chemical proteomic map of small-molecule/protein interactions in human cells. More than 170 stereoselective fragment–protein interactions were discovered and shown to occur at functional sites on proteins from diverse classes.

    • Yujia Wang
    • Melissa M. Dix
    • Benjamin F. Cravatt
    Research
    Nature Chemistry
    Volume: 11, P: 1113-1123