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Conformational gating mechanism for processive catalysis of β(1,3)-glucans

Processivity is a fundamental principle in biopolymer assembly and breakdown. This study uncovers a tunnel-based processive mechanism for the depolymerization of β(1,3)-glucans, expanding this paradigm to the major classes of β-glucans in nature.

Gustavo H. B. Gimenis
João P. M. Spadeto
Mario T. Murakami
ResearchOpen Access27 Mar 2026
Nature Communications

P: 1-16
Impact of nurse navigation and mobile app on brain tumor patients receiving oral anticancer therapy

Caroline Poisson
Adeline Duflot-Boukobza
Sarah N. Dumont
ResearchOpen Access15 Jan 2026
npj Digital Medicine

Volume: 9, P: 1-7
Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

In a multicenter, randomized trial of patients with atrial fibrillation and a low risk of thromboembolic events, treatment with the anticoagulant rivaroxaban showed no benefit in reducing cognitive decline, stroke or transient ischemic attack when compared to placebo.

Léna Rivard
Paul Khairy
William Liang
ResearchOpen Access07 Jan 2026
Nature Medicine

Volume: 32, P: 297-305
Publisher Correction: Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

Léna Rivard
Paul Khairy
William Liang
Amendments and CorrectionsOpen Access04 Feb 2026
Nature Medicine

Volume: 32, P: 767
Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland

Maria Letizia Motti
Angelo Boccia
Giuseppe Viglietto
Research23 Oct 2003
Oncogene

Volume: 22, P: 7576-7586
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

Synapse loss is prominent in the cortex in multiple sclerosis (MS). In a cortical MS model, Jafari et al. show that phagocytes remove synapses by engulfment, which is triggered by local calcium accumulations and prevented by blocking colony-stimulating factor 1 signaling.

Mehrnoosh Jafari
Adrian-Minh Schumacher
Martin Kerschensteiner
Research25 Jan 2021
Nature Neuroscience

Volume: 24, P: 355-367
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion

A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.

Clelton A. Santos
Mariana A. B. Morais
Mario T. Murakami
ResearchOpen Access12 Feb 2025
Nature

Volume: 639, P: 1076-1083
Integrated non-reciprocal magneto-optics with ultra-high endurance for photonic in-memory computing

Researchers demonstrate optical weights for in-memory photonic computing using magneto-optic memory cells comprising Ce:YIG on silicon micro-ring resonators. Non-reciprocal phase shift provides a fast, efficient and robust integrated optical processing platform.

Paolo Pintus
Mario Dumont
Nathan Youngblood
ResearchOpen Access23 Oct 2024
Nature Photonics

Volume: 19, P: 54-62
Clinical trial links oncolytic immunoactivation to survival in glioblastoma

Treatment with the oncolytic herpes virus CAN-3110 is associated with improved survival responses in patients with recurrent glioblastoma, particularly in individuals who are seropositive for HSV1.

Alexander L. Ling
Isaac H. Solomon
E. Antonio Chiocca
ResearchOpen Access18 Oct 2023
Nature

Volume: 623, P: 157-166
12.1 terabit/second data center interconnects using O-band coherent transmission with QD-MLL frequency combs

The authors showcase a cutting edge12.1 Tbps coherent optical fiber transmission system using two Quantum-Dot Mode-Locked Lasers as both carrier and LO, which opens the way for a cost-effective solution to scaling intra-data center interconnects capacities.

Santiago Bernal
Mario Dumont
David V. Plant
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-15
Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial

The phase 3 CAPRI clinical trial evaluating the impact of a digital nurse navigator-led system in patients receiving oral anticancer treatment shows that remote monitoring using a smartphone app results in an improved patient care experience and optimizes healthcare resources.

Olivier Mir
Marie Ferrua
Etienne Minvielle
Research25 Apr 2022
Nature Medicine

Volume: 28, P: 1224-1231
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.

Steven Lohard
Nathalie Bourgeois
Sophie Barillé-Nion
ResearchOpen Access14 Jan 2020
Nature Communications

Volume: 11, P: 1-16
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

A genome-wide association study for attention deficit/hyperactivity disorder (ADHD) identifies 12 loci and implicates neurodevelopmental pathways and conserved regions of the genome as being involved in underlying ADHD biology.

Ditte Demontis
Raymond K. Walters
Benjamin M. Neale
Research26 Nov 2018
Nature Genetics

Volume: 51, P: 63-75
Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas

D Vitagliano
G Portella
M Santoro
Research19 Jun 2006
Oncogene

Volume: 25, P: 5467-5474
Genome-wide association study identifies 30 loci associated with bipolar disorder

Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.

Eli A. Stahl
Gerome Breen
Pamela Sklar
Research01 May 2019
Nature Genetics

Volume: 51, P: 793-803
The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia–tracheoesophageal fistula

Currently, systematic care for adults and adolescents with oesophageal atresia–tracheoesophageal fistula (EA-TEF) as they transition into adulthood is lacking. A multidisciplinary group of experts structured this Consensus Statement offering guidelines for the care of adolescents and adults with EA-TEF during transition.

Usha Krishnan
Michael W. Dumont
Christophe Faure
Reviews07 Jun 2023
Nature Reviews Gastroenterology & Hepatology

Volume: 20, P: 735-755
Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer

Daniel R. Barnes
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access20 Nov 2025
npj Genomic Medicine

Volume: 10, P: 1-21
Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D

Multispectral large-scale single-cell resolution 3D imaging allows up to eight fluorophores to be captured in a single acquisition. This protocol enables the visualization and exploration of large intact tissue volumes.

Ravian L. van Ineveld
Raphaël Collot
Anne C. Rios
Protocols30 Sept 2022
Nature Protocols

Volume: 17, P: 3028-3055
Broadband quantum-dot frequency-modulated comb laser

This work investigates the optical nonlinearities of quantum-dot mode-locked lasers and demonstrates how to generate the amplitude-modulated and the frequency-modulated comb independently from a single device.

Bozhang Dong
Mario Dumont
John E. Bowers
ResearchOpen Access25 Jul 2023
Light: Science & Applications

Volume: 12, P: 1-12
International expert consensus on the current status and future prospects of artificial intelligence in metabolic and bariatric surgery

Mohammad Kermansaravi
Sonja Chiappetta
Natan Zundel
ResearchOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Transmission of bee-like vibrations in buzz-pollinated plants with different stamen architectures

Lucy Nevard
Avery L. Russell
Mario Vallejo-Marín
ResearchOpen Access29 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells

Fabiola Moretti
Antonella Farsetti
Alfredo Pontecorvi
Research13 Feb 1997
Oncogene

Volume: 14, P: 729-740
Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Denise G. O’Mahony
Susan J. Ramus
Elizabeth Santana dos Santos
ResearchOpen Access19 Apr 2023
British Journal of Cancer

Volume: 128, P: 2283-2294
Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Daniel R. Barnes
Matti A. Rookus
Antonis C. Antoniou
ResearchOpen Access15 Jul 2020
Genetics in Medicine

Volume: 22, P: 1653-1666
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Jair Tenorio
Pablo Alarcón
Pablo Lapunzina
Research04 Nov 2019
European Journal of Human Genetics

Volume: 28, P: 469-479
MDMA Induces EPSP–Spike Potentiation in Rat Ventral Hippocampus In Vitro Via Serotonin and Noradrenaline Release and Coactivation of 5-HT₄ and β₁ Receptors

Boris Mlinar
Simona Mascalchi
Renato Corradetti
Research25 Jul 2007
Neuropsychopharmacology

Volume: 33, P: 1464-1475
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clara Grilo
Tomé Neves
Eric Guinard
ResearchOpen Access31 Mar 2025
Scientific Data

Volume: 12, P: 1-14

Search

Conformational gating mechanism for processive catalysis of β(1,3)-glucans

Impact of nurse navigation and mobile app on brain tumor patients receiving oral anticancer therapy

Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

Publisher Correction: Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial

Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland

Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation

A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion

Integrated non-reciprocal magneto-optics with ultra-high endurance for photonic in-memory computing

Clinical trial links oncolytic immunoactivation to survival in glioblastoma

12.1 terabit/second data center interconnects using O-band coherent transmission with QD-MLL frequency combs

Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas

Genome-wide association study identifies 30 loci associated with bipolar disorder

The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia–tracheoesophageal fistula

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer

Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D

Broadband quantum-dot frequency-modulated comb laser

International expert consensus on the current status and future prospects of artificial intelligence in metabolic and bariatric surgery

Transmission of bee-like vibrations in buzz-pollinated plants with different stamen architectures

p53 re-expression inhibits proliferation and restores differentiation of human thyroid anaplastic carcinoma cells

Ovarian cancer pathology characteristics as predictors of variant pathogenicity in BRCA1 and BRCA2

Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants

Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

MDMA Induces EPSP–Spike Potentiation in Rat Ventral Hippocampus In Vitro Via Serotonin and Noradrenaline Release and Coactivation of 5-HT₄ and β₁ Receptors

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

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