Nature Search

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide

Laura K. M. Han
Willem B. Bruin
Moji Aghajani
ResearchOpen Access13 Jan 2026
Molecular Psychiatry

P: 1-16
Cerebral small vessel disease genomics and its implications across the lifespan

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

Muralidharan Sargurupremraj
Hideaki Suzuki
Stéphanie Debette
ResearchOpen Access08 Dec 2020
Nature Communications

Volume: 11, P: 1-18
Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease

Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.

Marie-Gabrielle Duperron
Maria J. Knol
Stéphanie Debette
ResearchOpen Access17 Apr 2023
Nature Medicine

Volume: 29, P: 950-962
Brain aging patterns in a large and diverse cohort of 49,482 individuals

Assessing brain aging heterogeneity in a cohort of 49,482 individuals from 11 studies, a generative model identifies five dominant patterns of brain atrophy, with specific associations with biomedical, lifestyle and genetic factors.

Zhijian Yang
Junhao Wen
Christos Davatzikos
Research15 Aug 2024
Nature Medicine

Volume: 30, P: 3015-3026
Concentrating solar technologies for low-carbon energy

Concentrating solar technologies can be used to generate electricity and process heat from sunlight, with the capability to store energy for use at night or when insolation is low. This Review discusses the status and perspectives in different fields of applications, as well as options for technical improvements.

Jana Stengler
Mark Bülow
Robert Pitz-Paal
Reviews29 Aug 2025
Nature Reviews Clean Technology

Volume: 1, P: 719-733
Genetic variants associated with longitudinal changes in brain structure across the lifespan

Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

Rachel M. Brouwer
Marieke Klein
Hilleke E. Hulshoff Pol
Research05 Apr 2022
Nature Neuroscience

Volume: 25, P: 421-432
Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

An increase in the volume of the brain lateral ventricles is a sign of normal aging, but can also be associated with neurological and psychiatric disorders. Here, Vojinovic et al. identify seven genetic loci in a GWA study for ventricular volume in 23,500 individuals and find correlation with thalamus volume.

Dina Vojinovic
Hieab H. Adams
Myriam Fornage
ResearchOpen Access26 Sept 2018
Nature Communications

Volume: 9, P: 1-11
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

Chaira Serrarens
Yara J. Toenders
Laura S. van Velzen
ResearchOpen Access03 Nov 2025
Molecular Psychiatry

Volume: 30, P: 5625-5636
Classification of major depressive disorder using vertex-wise brain sulcal depth, curvature, and thickness with a deep and a shallow learning model

Roberto Goya-Maldonado
Tracy Erwin-Grabner
Jan Ernsting
ResearchOpen Access03 Oct 2025
Molecular Psychiatry

P: 1-13
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E Sønderby
Ómar Gústafsson
Ole A. Andreassen
ResearchOpen Access03 Oct 2018
Molecular Psychiatry

Volume: 25, P: 584-602
Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures

Vladimir Belov
Tracy Erwin-Grabner
Roberto Goya-Maldonado
ResearchOpen Access11 Jan 2024
Scientific Reports

Volume: 14, P: 1-18
Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Nynke A. Groenewold
Janna Marie Bas-Hoogendam
Nic J. A. Van der Wee
Research19 Jan 2023
Molecular Psychiatry

Volume: 28, P: 1079-1089
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Ida E. Sønderby
Dennis van der Meer
Marianne B. M. van den Bree
ResearchOpen Access22 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-16
Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

Anita Harrewijn
Elise M. Cardinale
Daniel S. Pine
ResearchOpen Access01 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-15
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

L Schmaal
D P Hibar
D J Veltman
ResearchOpen Access03 May 2016
Molecular Psychiatry

Volume: 22, P: 900-909
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson
Neda Jahanshad
Vladimir Zelman
ReviewsOpen Access20 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-28
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E. Sønderby
Ómar Gústafsson
Ole A. Andreassen
Amendments and Corrections31 Jan 2019
Molecular Psychiatry

Volume: 25, P: 692-695

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