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The Singapore Genome Variation projects characterized the genetics of Singapore’s Chinese, Malay, and Indian populations. The Singapore Integrative Omics Study introduced here goes further in providing multi-omic measurements in individuals from these populations, including genetic, transcriptome, lipidome, and lifestyle data, and will facilitate the study of common diseases in Asian communities.

Comparisons of a chimeric recombinant version of SARS-CoV-2, the ancestral SARS-CoV-2 strain and an Omicron isolate show that the attenuated virulence of Omicron is caused by mutations in both the spike protein and nsp6.

The efficacy of T-cell-based cancer immunotherapies can be compromised by T cell exhaustion. Here the authors develop a human ex vivo exhaustion model and, based on a CRISPR-Cas9 screen, identify SNX9 as a regulator of T cell exhaustion, showing that SNX9 knockout is associated with improved T cell function and anti-tumor activity in preclinical cancer models.

Artificial Intelligence is transforming the study of extreme climate events like floods, droughts, and wildfires, helping to overcome challenges such as limited data and real-time integration. This review article highlights the need for transparent, reliable AI models to improve disaster response, risk communication and stakeholder trust.

A horizon scan was used to explore possible impacts of robotics and automated systems on achieving the UN Sustainable Development Goals. Positive effects are likely. Iterative regulatory processes and continued dialogue could help avoid environmental damages and increases in inequality.

A hydrogel serving as a high-capacity drug depot and combining a dissipative tough matrix on one side and a tendon-adhesive surface on the other side boosts tissue healing in rat models of tendon rupture.

Heterologous expression of recombinant proteins often results in misfolding, aggregation and degradation. Here, we show an in vivo dual-biosensor system that simultaneously assesses protein translation and protein folding, thereby enabling rapid screening of expression strains as well as mutant libraries.

Across two studies, people felt closer to AI than to humans after emotional chat interactions, but only if the AI was labelled as human. Labelling the partner as AI reduced, but did not prevent, relationship-building.

Magnetic-based isolators are critical components for protecting qubits against noise in quantum setups but unsuitable for large processors. Here, Abdo et al. show good protection of a qubit in a high-fidelity quantum readout setup using a Josephson-based isolator devoid of magnetic materials.

The availability of surface oxygen vacancies or electrons is often viewed as the defining factor for the reactivity of perovskite oxides. Two precisely controlled surfaces on SrTiO₃(110) show strikingly different O exchange kinetics, which the authors ascribe to the flexibility of the surface polyhedra.

The combination of interparticle interactions and a synthetic gauge field leads to chirality in the propagation dynamics of particles in a ladder-like lattice.

The bed bug, Cimex lectularius, is a ubiquitous human ectoparasite with global distribution. Here, the authors sequence the genome of the bed bug and identify reductions in chemosensory genes, expansion of genes associated with blood digestion and genes linked to pesticide resistance.

Claudia Langenberg, James Meigs and colleagues apply a joint meta-analysis approach that accounts for differences in body mass index to identify variants associated with glycemic traits. They report six new loci associated with fasting insulin levels and provide insights into the genetic basis of insulin resistance.

A Kv1 channel inhibitor and potential therapeutic lead achieves selectivity by binding both the conserved central cavity and newly identified side pockets, which provide the key determinants for channel specificity.

Netrins are secreted guidance factors that promote axon outgrowth and orientation during nervous system development. Here the authors present structural and biological evidence that netrin-4 is not a guidance cue per se, but rather functions to modulate laminin-laminin interactions.

Observations of ethane and propane distributions in the atmosphere are reproduced in simulations with an atmospheric chemistry transport model, if fossil emissions are a factor of two to three higher than previously assumed.

Quantum entanglement comes in a rich variety of types and families if more than two particles are involved. Experiments with photons are opening up fresh ways to systematically study multi-particle entanglement.

HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.

Metals can be strengthened by mechanisms that work on the atomic scale. These same mechanisms used at a much larger scale have been found to also strengthen materials that contain hierarchical, engineered substructures.

The oxytocin/oxytocin receptor (OT/OTR) signalling system is a promising therapeutic target for socioemotional disorders, yet its clinical potential is limited by a lack of in vivo molecular tools. Here, the authors develop and validate [¹⁸F]dOTK⁸[SFB] as a PET radiotracer, demonstrating its specificity and potential for in vivo mapping OT/OTR biodistribution.

Integrating inventory data with machine learning models reveals the global composition of tree types—needle-leaved evergreen individuals dominate, followed by broadleaved evergreen and deciduous trees—and climate change risks.

The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.

Physical inactivity is a major public health concern. This Perspective advocates for a complex systems approach to physical activity, emphasizing dynamic, interdisciplinary strategies to design more effective, theory-informed interventions.

Viral gene therapy can be limited by the efficacy of virion sequestration, immune responses and the silencing of genetic payloads. Here the authors engineer an advenovirus protein coat which shields the virion from the immune system while targeting cancer cells.

Pesticide pressure has the strongest association with ecological status in Germany particularly in low-order streams and the central highlands, as revealed by a new land use intensity index explicitly considering multiple hydrological information.

Plant-diversity effects on particulate and mineral-associated organic matter in soil remain underexplored. The authors propose that elucidating the mechanisms underlying these effects can help explain inconsistencies in plant-diversity–soil-carbon relationships across studies and better predict consequences of biodiversity loss/gain for soil carbon stocks.

This Review provides an overview of the main applications of single-port robotic surgery in urology, presenting emerging outcomes and discussing the transformative potential of this approach.

A silicon and tetracene solar cell employing singlet fission uses an eight-angstrom-thick hafnium oxynitride interlayer to promote efficient triplet transfer, increasing the efficiency of the cell.

Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of these protrusions are unknown—this is one of two studies identifying the ion channels that densely populate primary cilia, with direct measurements revealing cilia as a unique, functionally independent calcium signalling compartment that modulates hedgehog signalling pathways.

Memory T cells in peripheral tissues such as the lung lie in wait, ready to attack pathogens that try to reinvade the body. Work on mice infected with the influenza virus now identifies a molecule that keeps these T cells in their positions, and prevents them from dying off.

A nanobody-based immunolabeling method, vDISCO, boosts the signal of fluorescent proteins and allows imaging of subcellular details in intact transparent mice. It uncovers neuronal projections and skull–meninges connections in whole adult mice.

A comprehensive analysis of niche partitioning between two co-occurring, morphologically similar bat species reveals weak species-level differences, but strong variation between and within individuals.