Nature Search

The mottled gene is the mouse homologue of the Menkes disease gene

Barbara Levinson
Christopher Vulpe
Jane Gitschier
Research01 Apr 1994
Nature Genetics

Volume: 6, P: 369-373
Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019

Adrian A. N. Doevelaar
Martin Bachmann
Timm H. Westhoff
ResearchOpen Access28 Jun 2023
Scientific Reports

Volume: 13, P: 1-8
Extracellular DNA traps in inflammation, injury and healing

Various cell types release extracellular DNA traps that protect the host against microbial infections. In this Review, the authors discuss how DNA traps not only participate in pathogen clearance but can also promote vascular disease and autoimmunity.

Christoph Daniel
Moritz Leppkes
Martin Herrmann
Reviews18 Jun 2019
Nature Reviews Nephrology

Volume: 15, P: 559-575
Immunopathological manifestations in Kabuki syndrome: a registry study of 177 individuals

Henri Margot
Guilaine Boursier
David Geneviève
Research31 Jul 2019
Genetics in Medicine

Volume: 22, P: 181-188
BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis

Diana Prieto-Peña
Fernanda Genre
Raquel López-Mejías
ResearchOpen Access01 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
A genome-wide association study suggests the HLA Class II region as the major susceptibility locus for IgA vasculitis

Raquel López-Mejías
F. David Carmona
Miguel A. González-Gay
ResearchOpen Access11 Jul 2017
Scientific Reports

Volume: 7, P: 1-6
Vitamin D controls T cell antigen receptor signaling and activation of human T cells

The mechanism of T cell avidity maturation has remained elusive. Geisler and co-workers show that induction of the phospholipase PLC-γ1 via the alternative p38 pathway is required for avidity maturation in naive human T cells.

Marina Rode von Essen
Martin Kongsbak
Carsten Geisler
Research07 Mar 2010
Nature Immunology

Volume: 11, P: 344-349
Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder — recommendations from ECTRIMS and the EBMT

Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for some forms of multiple sclerosis (MS), but uncertainties remain about its implementation in clinical practice and treatment protocols need to be optimized. This Consensus Statement provides guidance and recommendations for the use of AHSCT in MS and neuromyelitis optica spectrum disorders.

Paolo A. Muraro
Alice Mariottini
Helene Zephir
Reviews15 Jan 2025
Nature Reviews Neurology

Volume: 21, P: 140-158
Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis

Diana Prieto-Peña
Sara Remuzgo-Martínez
Raquel López-Mejías
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-8
Adult neurogenesis improves spatial information encoding in the mouse hippocampus

Adult neurogenesis is a unique form of neuronal plasticity, involving the genesis and integration of newborn neurons into the mouse dentate gyrus. Here the authors demonstrate that adult neurogenesis improves representations of space in the dentate gyrus by increasing the place-specific responses of mature neurons.

M. Agustina Frechou
Sunaina S. Martin
J. Tiago Gonçalves
ResearchOpen Access30 Jul 2024
Nature Communications

Volume: 15, P: 1-14
Control of a hippocampal recurrent excitatory circuit by cannabinoid receptor-interacting protein Gap43

Cannabis impacts our brain by engaging the CB₁ receptor. Here, the authors identify a protein called GAP43 that interacts with CB₁ and blocks its synaptic functions. This finding provides a conceptual view to understand how CB₁ acts in the brain.

Irene B. Maroto
Carlos Costas-Insua
Manuel Guzmán
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-16
Drug Insight: the use of intravenous immunoglobulin in neurology—therapeutic considerations and practical issues

Intravenous immunoglobulin has an important role in the treatment of numerous neuroimmunological disorders, including Guillain–Barré syndrome and multiple sclerosis. In this article, Gold et al. review current and future indications for intravenous immunoglobulin treatment, discuss its proposed mechanisms of action, and highlight various practical issues relating to its use in the clinic.

Ralf Gold
Martin Stangel
Marinos C Dalakas
Reviews01 Jan 2007
Nature Clinical Practice Neurology

Volume: 3, P: 36-44
Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer

In this Consensus Statement, members from five working groups or societies provide updated comprehensive recommendations to manage toxicities from cancer immunotherapies in children, adolescents and young adults. In their recommendations, they advocate for the adoption of age-based and discipline-specific management criteria, and call for an increased inclusion of young patients with cancer in clinical trials.

Dristhi Ragoonanan
Sajad J. Khazal
Kris M. Mahadeo
Reviews19 Feb 2021
Nature Reviews Clinical Oncology

Volume: 18, P: 435-453
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

In this Review, Hwa and colleagues summarize the latest advances in platelet biology and function and appraise the technical and biological challenges in platelet investigations.

Tarun Tyagi
Kanika Jain
John Hwa
Reviews03 Mar 2022
Nature Cardiovascular Research

Volume: 1, P: 223-237
Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial

Ralf Jäger
Sidney Abou Sawan
Pee-Win Chong
ResearchOpen Access03 Jun 2024
Scientific Reports

Volume: 14, P: 1-12
Host–microbiota interactions in immune-mediated diseases

In this Review, Ruff, Greiling and Kriegel discuss the mechanisms through which the microbiota contributes to the predisposition, initiation and perpetuation of immune-mediated diseases, and explore the therapeutic avenues that either target the microbiota, the barrier surfaces or the host immune system to restore tolerance and homeostasis.

William E. Ruff
Teri M. Greiling
Martin A. Kriegel
Reviews26 May 2020
Nature Reviews Microbiology

Volume: 18, P: 521-538
Unveiling new genetic insights in rheumatoid arthritis for drug discovery through Taxonomy3 analysis

Justyna Kozlowska
Neil Humphryes-Kirilov
Alun McCarthy
ResearchOpen Access19 Jun 2024
Scientific Reports

Volume: 14, P: 1-14
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

This Review summarizes the latest evidence indicating that platelet and endothelial dysfunction are essential components of COVID-19 pathology, describes the potential mechanisms underlying the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19, and highlights the roles of coagulopathy, thrombocytopathy and endotheliopathy in COVID-19 pathogenesis.

Sean X. Gu
Tarun Tyagi
John Hwa
Reviews19 Nov 2020
Nature Reviews Cardiology

Volume: 18, P: 194-209
Unravelling the association of partial T-cell immunodeficiency and immune dysregulation

Surprisingly, and somewhat counter-intuitively, partial T-cell immunodeficiencies are commonly associated with hyper-immune dysregulation. Here, the authors review the genetic basis of such immunodeficiencies and draw on mouse models to provide a potential explanation for the coexistence of immunodeficiency and autoimmunity.

Adrian Liston
Anselm Enders
Owen M. Siggs
Reviews01 Jul 2008
Nature Reviews Immunology

Volume: 8, P: 545-558
Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

A study of 4,645 children in four countries in East Africa, 800 with Burkitt lymphoma (BL), identifies an association between HLA-DQA1*04:01 and variant rs2040406(G) and elevated risk of BL in Africa.

Zhiwei Liu
Yang Luo
Sam M. Mbulaiteye
ResearchOpen Access05 Jan 2024
Communications Biology

Volume: 7, P: 1-9
Long-term follow-up of patients with mantle cell lymphoma (MCL) treated with the selective Bruton’s tyrosine kinase inhibitor tirabrutinib (GS/ONO-4059)

Simon A. Rule
Guillaume Cartron
Martin J. S. Dyer
ResearchOpen Access11 Dec 2019
Leukemia

Volume: 34, P: 1458-1461
Clinical sites of the Undiagnosed Diseases Network: unique contributions to genomic medicine and science

Kelly Schoch
Cecilia Esteves
Vandana Shashi
Research23 Oct 2020
Genetics in Medicine

Volume: 23, P: 259-271
Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities

T Furlong
R Storb
RA Nash
Research20 Nov 2000
Bone Marrow Transplantation

Volume: 26, P: 985-991
Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

Pedro Magalhães
Martin Pejchinovski
Joost P. Schanstra
ResearchOpen Access05 Dec 2017
Scientific Reports

Volume: 7, P: 1-8
Venous thrombosis and predictors of relapse in eosinophil-related diseases

Valériane Réau
Alexandre Vallée
Matthieu Groh
ResearchOpen Access18 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Pooled analysis of safety data from clinical trials evaluating acalabrutinib monotherapy in mature B-cell malignancies

Richard R. Furman
John C. Byrd
Jeff P. Sharman
Research27 Apr 2021
Leukemia

Volume: 35, P: 3201-3211
Urinary proteome signature of Renal Cysts and Diabetes syndrome in children

Pierbruno Ricci
Pedro Magalhães
Petra Zürbig
ResearchOpen Access18 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Evidence that deletion at FCGR3B is a risk factor for systemic sclerosis

C McKinney
J C A Broen
T R Merriman
Research03 May 2012
Genes & Immunity

Volume: 13, P: 458-460
Increased TRPC3 expression in vascular endothelium of patients with malignant hypertension

Florian Thilo
Christoph Loddenkemper
Martin Tepel
Research09 Jan 2009
Modern Pathology

Volume: 22, P: 426-430
Changes in urinary metabolomic profile during relapsing renal vasculitis

Bahjat Al-Ani
Martin Fitzpatrick
Mark A. Little
ResearchOpen Access01 Dec 2016
Scientific Reports

Volume: 6, P: 1-11
Sustained virological response to hepatitis C therapy does not decrease the incidence of systemic lupus erythematosus or rheumatoid arthritis

Wei-Fan Hsu
Chi-Yi Chen
Cheng-Yuan Peng
ResearchOpen Access25 Mar 2020
Scientific Reports

Volume: 10, P: 1-8
Prophylactic i.v. Igs in patients with a high risk for CMV after allo-SCT

M Schmidt-Hieber
S Schwarck
I W Blau
Research19 Jan 2009
Bone Marrow Transplantation

Volume: 44, P: 185-192
Relapse, not regimen-related toxicity, was the major cause of treatment failure in 11 children with Down syndrome undergoing haematopoietic stem cell transplantation for acute leukaemia

B Meissner
A Borkhardt
M Sauer
Research03 Sept 2007
Bone Marrow Transplantation

Volume: 40, P: 945-949
Acute balenine supplementation in humans as a natural carnosinase-resistant alternative to carnosine

Sarah de Jager
An Vermeulen
Wim Derave
ResearchOpen Access20 Apr 2023
Scientific Reports

Volume: 13, P: 1-10
Glucocorticoid treatment for non-cerebral diseases in children and adolescents is associated with differences in uncinate fasciculus microstructure

Martin Vestergaard
William F. C. Baaré
Kathrine Skak Madsen
Research31 Mar 2021
Pediatric Research

Volume: 91, P: 879-887
Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation

Chien-Shing Chen
M Boeckh
K M Sullivan
Research27 Aug 2003
Bone Marrow Transplantation

Volume: 32, P: 515-522
Phase I/II study of gemtuzumab ozogamicin added to fludarabine, melphalan and allogeneic hematopoietic stem cell transplantation for high-risk CD33 positive myeloid leukemias and myelodysplastic syndrome

M de Lima
R E Champlin
S Giralt
Research08 Nov 2007
Leukemia

Volume: 22, P: 258-264
Autoimmune cytopenias following pediatric hematopoietic cell transplant

Jacob R. Greenmyer
Sydney Ariagno
Mira Kohorst
Correspondence04 Oct 2023
Bone Marrow Transplantation

Volume: 59, P: 117-120
Quantitative analysis of the natural history of prolidase deficiency: description of 17 families and systematic review of published cases

Francis Rossignol
Marvid S. Duarte Moreno
Manuel Schiff
Reviews26 May 2021
Genetics in Medicine

Volume: 23, P: 1604-1615
Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network

Heinz Ludwig
Michel Delforge
Pieter Sonneveld
ReviewsOpen Access02 May 2018
Leukemia

Volume: 32, P: 1542-1560
Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL)

B Wassmann
H Pfeifer
OG Ottmann
Comments & Opinion26 Nov 2002
Leukemia

Volume: 16, P: 2358-2365
Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation

J A Snowden
R Saccardi
D Farge
Special FeaturesOpen Access17 Oct 2011
Bone Marrow Transplantation

Volume: 47, P: 770-790

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