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Showing 1–50 of 106 results

Advanced filters: Author: Masatoshi Watanabe Clear advanced filters

DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Several Interesting Fields Exploited through Understanding of Polymeric Effects on Liquid Crystals of Main-Chain Polyesters

Masatoshi Tokita
Junji Watanabe
Reviews20 Jun 2006
Polymer Journal

Volume: 38, P: 611-638
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
Thermotropic Liquid Crystals of Main-Chain Polyesters with a Mesogenic 4,4′-Biphenyldicarboxylate Unit XII. Unusual Molecular Orientation in Fibers Drawn from Smectic Melt

Masatoshi Tokita
Kensuke Osada
Junji Watanabe
Research01 Aug 1998
Polymer Journal

Volume: 30, P: 687-690
Rigid-Rod Polyesters with Flexible Side Chains IX. Phase Behavior Including Nematic, Layered, and Hexagonal Columnar Phases in Poly(p-biphenylene terephthalate) with Alkoxy Side Chains

Kai Fu
Nobuhiro Sekine
Junji Watanabe
Research01 Apr 2002
Polymer Journal

Volume: 34, P: 291-297
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Dielectric Relaxation and Molecular Motion in the Chiral Main-Chain Liquid Crystalline Copolyester, BB-4^*(2-Me)/BB-6

Takeo Furukawa
Osamu Uchinokura
Junji Watanabe
Research01 Feb 2000
Polymer Journal

Volume: 32, P: 122-126
Function of the Corpus Allatum in ‘Dauer-pupa’ of the Silkworm, Bombyx mori

MASATOSHI KOBAYASHI
Research23 Jul 1960
Nature

Volume: 187, P: 346-347
Thermotropic Liquid Crystals of Main-Chain Polyesters Having a Mesogenic 4,4′-Biphenyldicarboxylate Unit XI. Smectic Liquid Crystalline Glass

Masatoshi Tokita
Kensuke Osada
Junji Watanabe
Research01 Jul 1998
Polymer Journal

Volume: 30, P: 589-595
Magnetic Orientation of Microcylinders in Liquid Crystalline Diblock Copolymer and Clarification of Its Orientation Mechanism

Mitsu-aki Adachi
Fumihiro Takazawa
Junji Watanabe
Research14 Dec 2006
Polymer Journal

Volume: 39, P: 155-162
Side-Chain Liquid Crystalline Block Copolymers with Well Defined Structures Prepared by Living Anionic Polymerization IV. Microphase Morphology in Blends with Coil Homopolystyrenes

Tomomichi Itoh
Naoki Tomikawa
Junji Watanabe
Research01 Oct 2001
Polymer Journal

Volume: 33, P: 783-791
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Aromatic Polyesters with Flexible Side Chains. 10. Studies on Biaxiality in Nematic Liquid Crystal of BC-n Polyester

Kai Fu
Masato Sone
Junji Watanabe
Reviews15 Apr 2006
Polymer Journal

Volume: 38, P: 442-446
Ribosome Formation from Subunits: Dependence on Formylmethionyl-transfer RNA in Extracts from E. coli

MASATOSHI KONDO
GUDMUNDUR EGGERSTON
PETER LENGYEL
Research01 Oct 1968
Nature

Volume: 220, P: 368-371
Silica films with a single-crystalline mesoporous structure

Hirokatsu Miyata
Takashi Suzuki
Kazuyuki Kuroda
Research15 Aug 2004
Nature Materials

Volume: 3, P: 651-656
Twin pregnancies are risk factors for both early- and late-onset hypertensive disorders of pregnancy: the Japan Environment and Children’s study

We showed that both dichorionic diamniotic and monochorionic diamniotic twin pregnancies are risk factors for the development of early-onset and late-onset hypertensive disorders of pregnancy

Kazuma Tagami
Noriyuki Iwama
Masatoshi Saito
ResearchOpen Access09 Jan 2026
Hypertension Research

P: 1-12
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
An α₁-Receptor Blocker Reduces Plasma Leptin Levels in Hypertensive Patients with Obesity and Hyperleptinemia

Shunichi Ihara
Ken Shimamoto
Masatoshi Kawana
Research01 Oct 2006
Hypertension Research

Volume: 29, P: 805-811
Synthesis of structurally controlled hyperbranched polymers using a monomer having hierarchical reactivity

Hyperbranched polymers are used in many applications due to their advantageous properties such as low intrinsic viscosity, low glass transition temperature, and large number of terminal groups. Here the authors show a one-step synthesis of structurally well-controlled dendritic hyperbranched polymers.

Yangtian Lu
Takashi Nemoto
Shigeru Yamago
ResearchOpen Access30 Nov 2017
Nature Communications

Volume: 8, P: 1-8
Pumpless arteriovenous extracorporeal membrane oxygenation for 2000 g newborns with respiratory failure: proof of principle data from a preterm lamb model

Haruo Usuda
Hideyuki Ikeda
Matthew W. Kemp
Research06 Oct 2025
Pediatric Research

P: 1-12
Induced immunity by expression of interleukin-2 or GM-CSF gene in murine neuroblastoma cells can generate antitumor response to established tumors

Hideo Yoshida
Masahiro Tanabe
Masatoshi Tagawa
Research02 Nov 1999
Cancer Gene Therapy

Volume: 6, P: 395-401
Multi-omics analysis defines highly refractory RAS burdened immature subgroup of infant acute lymphoblastic leukemia

The molecular heterogeneity of KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) remains poorly characterised. Here, the authors perform multi-omics analysis for 84 ALL patients and suggest 5 distinct subgroups for risk stratification and personalised treatment.’

Tomoya Isobe
Masatoshi Takagi
Junko Takita
ResearchOpen Access30 Aug 2022
Nature Communications

Volume: 13, P: 1-16
Solid-State ¹³C NMR Analysis of the Crystalline–Noncrystalline Structure and Chain Conformation of Thermotropic Liquid Crystalline Polyester

Miwa Murakami
Hiroyuki Ishida
Junji Watanabe
Research14 Oct 2004
Polymer Journal

Volume: 36, P: 830-840
Correction: Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
Amendments and CorrectionsOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1
The Role of Epigenetic Modifications in Retinoic Acid Receptor β2 Gene Expression in Human Prostate Cancers

Tsuyoshi Nakayama
Masatoshi Watanabe
Taizo Shiraishi
Research01 Jul 2001
Laboratory Investigation

Volume: 81, P: 1049-1057
Epigenetic Regulation of Androgen Receptor Gene Expression in Human Prostate Cancers

Tsuyoshi Nakayama
Masatoshi Watanabe
Taizo Shiraishi
Research01 Dec 2000
Laboratory Investigation

Volume: 80, P: 1789-1796
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Sulphostin, a Novel Inhibitor of Dipeptidyl Peptidases IV (DPPIV) That Stimulates Hematopoiesis in Mice

Masatoshi Abe
Fuminori Abe
Tetsushi Saino
Research01 Feb 2005
The Journal of Antibiotics

Volume: 58, P: 111-117
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Artificial Membranes from Multiblock Copolymer IV. Four-Component Pentablock Copolymers of the DSD′AD Type Usable to Fabricate a Charge-Mosaic Membrane

Shin-ichi Takahashi
Kosaburo Matsumura
Yoshiyuki Miyaki
Research01 Jan 1986
Polymer Journal

Volume: 18, P: 41-49
Recyclable Shape-memory and Mechanical Strength of Poly(lactic acid) Compounds Cross-linked by Thermo-reversible Diels-Alder Reaction

Midori Yamashiro
Kazuhiko Inoue
Masatoshi Iji
Research04 Jun 2008
Polymer Journal

Volume: 40, P: 657-662
Expression of CD109 in human cancer

Mizuo Hashimoto
Masatoshi Ichihara
Masahide Takahashi
Research29 Apr 2004
Oncogene

Volume: 23, P: 3716-3720
Chemically defined cytokine-free expansion of human haematopoietic stem cells

A culture system allows the long-term expansion of human haematopoietic stem cells (HSCs) in vivo without the use of recombinant cytokines or albumin, with potential applications for clinical therapies involving HSCs.

Masatoshi Sakurai
Kantaro Ishitsuka
Satoshi Yamazaki
Research22 Feb 2023
Nature

Volume: 615, P: 127-133
Non-electrostatic interactions associated with aggregate formation between polyallylamine and Escherichia coli

Masatoshi Nakatsuji
Natsuki Sato
Hideki Ishihara
ResearchOpen Access08 Sept 2023
Scientific Reports

Volume: 13, P: 1-9
Role of citron kinase as a target of the small GTPase Rho in cytokinesis

Pascal Madaule
Masatoshi Eda
Shuh Narumiya
Research30 Jul 1998
Nature

Volume: 394, P: 491-494
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-17
Effects of transcranial static magnetic stimulation over the primary motor cortex on local and network spontaneous electroencephalogram oscillations

Sumiya Shibata
Tatsunori Watanabe
Tatsuya Mima
ResearchOpen Access15 Apr 2021
Scientific Reports

Volume: 11, P: 1-7
Transcranial static magnetic stimulation over the motor cortex can facilitate the contralateral cortical excitability in human

Yasuyuki Takamatsu
Satoko Koganemaru
Tatsuya Mima
ResearchOpen Access08 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Machine learning-based models for predicting clinical outcomes after surgery in unilateral primary aldosteronism

Hiroki Kaneko
Hironobu Umakoshi
Yoshihiro Ogawa
ResearchOpen Access06 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

In vitro differentiation of human pluripotent stem cells (hPSCs) has enabled the generation of neuroectodermal tissues. Here, Sakaguchi et al.use a modified neocortical induction method to generate functional hippocampal granule and pyramidal-like neurons, as well as dorsomedial telencephalic tissues from hPSCs.

Hideya Sakaguchi
Taisuke Kadoshima
Yoshiki Sasai
ResearchOpen Access17 Nov 2015
Nature Communications

Volume: 6, P: 1-11
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
Research21 Jan 2019
Hypertension Research

Volume: 42, P: 558-566
Visual Responses of Photoreceptor-Degenerated Rats Expressing Two Different Types of Channelrhodopsin Genes

Masatoshi Sato
Eriko Sugano
Hiroshi Tomita
ResearchOpen Access23 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Infection perturbs Bach2- and Bach1-dependent erythroid lineage ‘choice’ to cause anemia

Environmental cues instruct cell fate during hematopoiesis. Igarashi and colleagues show that the transcription factors Bach1 and Bach2 promote erythropoiesis and suppress myelopoiesis. Infection and inflammatory signals suppress Bach expression, which results in anemia.

Hiroki Kato
Ari Itoh-Nakadai
Kazuhiko Igarashi
Research24 Sept 2018
Nature Immunology

Volume: 19, P: 1059-1070
StayGold variants for molecular fusion and membrane-targeting applications

Monomeric and tandem dimer derivatives of the bright and photostable green fluorescent protein StayGold offer versatile tools for tagging target proteins and membranes in extended live-cell imaging.

Ryoko Ando
Satoshi Shimozono
Atsushi Miyawaki
ResearchOpen Access30 Nov 2023
Nature Methods

Volume: 21, P: 648-656
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors

Embryonic stem cells are typically driven to adopt a neural fate in response to inductive signals originating from the environment. However, little is known regarding the downstream molecular mechanisms operating intracellularly to induce this transformation and differentiation. Here, the zinc-finger nuclear protein Zfp521 is demonstrated to be necessary and sufficient to force a neural fate, providing evidence for a cell-intrinsic factor important in transitioning multipotent ES cells to a neural fate.

Daisuke Kamiya
Satoe Banno
Yoshiki Sasai
Research16 Feb 2011
Nature

Volume: 470, P: 503-509
Polar recruitment of RLD by LAZY1-like protein during gravity signaling in root branch angle control

In Arabidopsis, LZY proteins are involved in specifying the angle of root growth relative to the direction of gravity. Here the authors identify RLD1, a LZY-interacting protein that is recruited to the plasma membrane in a polar manner and is required to establish asymmetric auxin transport and set root angles.

Masahiko Furutani
Yoshinori Hirano
Miyo Terao Morita
ResearchOpen Access03 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Structural Changes in Wood Pulp Treated by 55 wt% Aqueous Calcium Thiocyanate Solution

Makiko Hattori
Yoshihiko Shimaya
Masatoshi Saito
Research01 Jan 1998
Polymer Journal

Volume: 30, P: 37-42
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26

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