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Showing 1–3 of 3 results
Advanced filters: Author: Maurits van den Berg Clear advanced filters

  • Determinants of WEE1 inhibitor sensitivity in cancer cells are largely undefined. Here, the authors show that WEE1 inhibitors beyond their cell cycle perturbing effects also lead to paradoxical activation of the integrated stress response kinase GCN2.

    • Rinskje B. Tjeerdsma
    • Timothy F. Ng
    • Marcel A.T.M. van Vugt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Flores et al. show that brain-penetrant eIF2B agonists suppress ISR activation in cellular and mouse models of ALS and reduce ISR biomarkers in humans, enabling further clinical studies of ISR inhibition in individuals with neurological diseases

    • Brittany N. Flores
    • Seungyoon B. Yu
    • Joseph W. Lewcock
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Understanding of the effects of elevated CO2 on crops has improved sufficiently that modelling future climatic effects on agriculture should eliminate ‘no CO2’ simulations. Further advancement in the estimation of the effects can be realized by studying a wider variety of crop species under a wider range of growing conditions, improving the representation of responses to climate extremes in crop models and simulating additional crop physiological processes related to nutritional quality.

    • Andrea Toreti
    • Delphine Deryng
    • Cynthia Rosenzweig
    Reviews
    Nature Food
    Volume: 1, P: 775-782