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Advanced filters: Author: Megan Schertzer Clear advanced filters

Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox

The majority of human genes can produce multiple isoforms, but studying their functional relevance requires tools to target specific isoforms. Here, the authors develop a CRISPR-based exon-exon junction-targeting strategy to achieve isoform-specific RNA knockdown.

Megan D. Schertzer
Andrew Stirn
David A. Knowles
ResearchOpen Access29 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM

Differential isoform usage is identified with high statistical power from spatial transcriptomics data.

Jiayu Su
Yiming Qu
Raul Rabadan
ResearchOpen Access05 Jan 2026
Nature Biotechnology

P: 1-12
Functional classification of long non-coding RNAs by k-mer content

SEEKR is a method that deconstructs linear sequence relationships between lncRNAs and evaluates similarity on the basis of abundance of short motifs called k-mers. LncRNAs of related function often have similar k-mer profiles despite lacking linear homology.

Jessime M. Kirk
Susan O. Kim
J. Mauro Calabrese
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1474-1482