Nature Search

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

Kai Zhuang
Liu Zi
Jie Zhang
Research19 Dec 2025
Nature Aging

Volume: 6, P: 200-220
Synaptotagmin-1 serves as a primary Zn²⁺ sensor to mediate spontaneous neurotransmitter release under pathological conditions

In the pre-synapse, vesicle fusion is a key process for neurotransmitter release in the nervous system. Here authors demonstrate under pathological condition, synaptotagmin1 with Zn²⁺ adopts an alternative mode to regulate spontaneous neurotransmitter release.

Yijuan Xiang
Lele Cui
Ying Lai
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-13
Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Breast cancer cells interact with cancer-associated adipocytes in the microenvironment. Here, the authors report that the cross-talk between these two cell types is dependent on Zeb1, which remodels the tumor-associated adipose microenvironment to confer breast cancer progression.

Lixia Cao
Wei Sun
Shuang Yang
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-22
Aqueous hybrid electrochemical capacitors with ultra-high energy density approaching for thousand-volts alternating current line filtering

Filtering capacitors are essential to smooth high voltage alternating current lines but are typically limited to hundreds of volts. Here, the authors demonstrate an aqueous hybrid electrochemical capacitor that can exhibit an operating voltage of 1,000 V when assembled into a device of 670 units.

Zhou Li
Xiaopeng Wang
Liangti Qu
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-11
Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis

Xiao Chen
Lixia Cao
Shuang Yang
Research06 Oct 2025
British Journal of Cancer

Volume: 133, P: 1815-1828
Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer

Changpeng Li
Jingcai He
Hui Zheng
ResearchOpen Access24 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-13
Population differentiation of Rhodobacteraceae along with coral compartments

Danli Luo
Xiaojun Wang
Haiwei Luo
Research20 May 2021
The ISME Journal

Volume: 15, P: 3286-3302
A simple protocol to establish a conditionally immortalized mouse podocyte cell line

Yujiao Huang
Jie Geng
Anlong Xu
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-14
Carbon price prediction based on decomposition technique and extreme gradient boosting optimized by the grey wolf optimizer algorithm

Mengdan Feng
Yonghui Duan
Lanlan Ma
ResearchOpen Access27 Oct 2023
Scientific Reports

Volume: 13, P: 1-23
Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation

Shanshan Guan
Tianao Wang
Yaming Shan
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-14
In situ, high-resolution evidence for iron-coupled mobilization of phosphorus in sediments

Shiming Ding
Yan Wang
Chaosheng Zhang
ResearchOpen Access18 Apr 2016
Scientific Reports

Volume: 6, P: 1-11
Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction

Mengdan Miao
Shanhu Cao
Mingqi Zheng
ResearchOpen Access08 Jul 2023
Genes & Immunity

Volume: 24, P: 159-170
cFLIP_S regulates alternative NLRP3 inflammasome activation in human monocytes

Yuhui Gao
Shi Yu
Guangxun Meng
Research17 Aug 2023
Cellular & Molecular Immunology

Volume: 20, P: 1203-1215
Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

Songwei He
Fuhui Wang
Hui Zheng
ResearchOpen Access12 Feb 2019
Cell Discovery

Volume: 5, P: 1-17
Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep

Cunyuan Li
Xiaoyue Li
Shengwei Hu
ResearchOpen Access23 Nov 2017
Scientific Reports

Volume: 7, P: 1-10
Sequential EMT-MET induces neuronal conversion through Sox2

Songwei He
Jinlong Chen
Hui Zheng
ResearchOpen Access30 May 2017
Cell Discovery

Volume: 3, P: 1-14
Human organoids in basic research and clinical applications

Xiao-Yan Tang
Shanshan Wu
Yan Liu
ReviewsOpen Access24 May 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-17

Search

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Synaptotagmin-1 serves as a primary Zn²⁺ sensor to mediate spontaneous neurotransmitter release under pathological conditions

Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Aqueous hybrid electrochemical capacitors with ultra-high energy density approaching for thousand-volts alternating current line filtering

Breast cancer cell-derived adrenomedullin confers cancer-associated adipose remodeling through the cAMP/Creb1/Zeb1 axis

Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer

Population differentiation of Rhodobacteraceae along with coral compartments

A simple protocol to establish a conditionally immortalized mouse podocyte cell line

Carbon price prediction based on decomposition technique and extreme gradient boosting optimized by the grey wolf optimizer algorithm

Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation

In situ, high-resolution evidence for iron-coupled mobilization of phosphorus in sediments

Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction

cFLIP_S regulates alternative NLRP3 inflammasome activation in human monocytes

Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming

Genome-wide analysis of circular RNAs in prenatal and postnatal pituitary glands of sheep

Sequential EMT-MET induces neuronal conversion through Sox2

Human organoids in basic research and clinical applications

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