Search

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Qubit-cavity entanglement can be used for quantum information processing and for investigating the quantum-to-classical transition with high control. Here, the authors characterize the entanglement between an artificial atom and a cat state and its susceptibility to decoherence through Bell test witnesses.

Recent advances with molecular qubits have enabled the implementation of spin quantum teleportation (QT), albeit with limited fidelity & applicability. Here, the authors demonstrate optimal QT of spin states via hole transfer in covalently linked acceptor-donor-radical molecules, opening towards rational design of molecular materials for coherent information transfer.

Long-lived entanglement is a key resource for quantum metrology with optical clocks. Rydberg-based entangling gates within arrays of neutral atoms enable the generation of clock-transition Bell states with high fidelity and long coherence times.

Recombination can speed up adaptation by bringing beneficial alleles together. However, this study shows rapid adaptation in Threespine Stickleback fish depends more on the initial frequency of alleles and mating of key individuals than recombination.

An 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art Bell-state fidelities of up to 99.5%.

Quantum error correction codes protect quantum information, but running algorithms also requires the ability to perform gates on logical qubits. A lattice surgery scheme for fault-tolerant gates has now been demonstrated in a quantum repetition code.

The mitogen-activated protein kinases Erk and p38 transduce Toll-like receptor signals that lead to antigen capture by dendritic cells. New work identifies 'downstream' effector kinases essential for these responses and traces a pathway of mitogen-activated protein kinase signaling apparently unique to dendritic cells.

A study demonstrates a public generator of random numbers based on device-independent techniques, with the randomness being fully auditable and traceable.

JWST phase-curve observations reveal that the two innermost TRAPPIST-1 planets emit thermal radiation consistent with bare rocky surfaces, indicating that both lack thick atmospheres.

Spontaneous parametric down-conversion, the standard technique for generating entangled photons, is limited by low pair extraction efficiencies at near-unity fidelity. The authors show quantum dots in nanowires efficiently emit an oscillating state with near-unity entanglement fidelity and propose a time-resolved quantum key distribution protocol.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Lange, Ratz, et al. investigate the number and distribution of human prohibitin complexes in the mitochondrial inner membrane, uncovering their bell-shaped structure and assembly of alternating PHB1 and PHB2 molecules.

Language models can write human-readable code that captures general design rules, generating whole families of quantum experiments at once. A design strategy described here makes results interpretable and scalable, as well as accelerates discovery.

Quantum steering is a form of quantum non-locality that can be verified for arbitrarily low detection efficiencies and high losses at the price of requiring complete trust in one of the parties. Here, Kocsis et al. present measurement-device-independent steering protocols that remove this need for trust.

A programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits is described, in which improvement of algorithmic performance using a variety of error-correction codes is enabled.

Reconfigurable arrays of up to 448 neutral atoms are used to implement and combine the key elements of a universal, fault-tolerant quantum processing architecture and experimentally explore their underlying working mechanisms.

Impressive progress has been achieved in isolating quantum systems from the environment and coherently controlling their dynamics. However, engineering the dynamics of many particles by a controlled coupling to an environment (in an 'open' quantum system) remains largely unexplored. Here, an approach is demonstrated based on ion-trap technology for simulating an open quantum system with up to five qubits. By adding controlled dissipation to coherent operations, the work offers novel prospects for open-system quantum simulation and computation.

Quantum teleportation moves the quantum state of a system between physical locations without losing its coherence, an essential criterion for emerging quantum information applications. Now, electron-spin-state teleportation in covalent organic electron donor–acceptor–stable radical molecules is demonstrated using entangled electron spins produced by photo-induced electron transfer.

Here, the authors look at present day and medieval genome samples from Northern France to piece together demographic history and population structure across Brittany and the Loire basin.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Temporal patterns in global oil shipping reveal tankers exploring varied routes spend up to 50% more time carrying instead of seeking cargo. Tracking cargo flows uncovers annual cycles with 16% swings-insights that could optimize costs and emissions.

An electrically driven on-chip light source of entangled photon pairs is developed by combining an InP gain section and Si₃N₄ microrings. A pair generation rate of 8,200 counts s⁻¹ and a coincidence-to-accidental ratio of more than 80 are achieved around the wavelength of 1,550 nm.

Catch bonds are unique protein-protein interactions where the bond lifetime increases under external pulling forces. Here, the authors engineer an artificial catch bond based on a non-catch bonding human gut bacterial adhesion protein complex.

DNA rotaxanes can be prepared using a simple interlocking approach in which a DNA rod is threaded through a DNA macrocycle by base pairing.

Personal names vary across cultures. Here, the authors show how historical name systems share a common information structure, reflecting pressure for efficient communication, as well as laws changing these systems and introducing systematic bias.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Deterministic sources of entangled photons are important for photonic quantum networks, but many applications are only possible when their wavelengths are tunable. Here, the authors use on-chip strain engineering to demonstrate such a source with silicon-integrated InAs/GaAs quantum dots.

This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Automated pathotyping of synovial tissue in arthritis is a major unmet need. Here, the authors develop and demonstrate the efficacy of an automated tissue and cellular pathotyping tool for inflammatory arthritis.

Wastewater-based surveillance tends to focus on specific pathogens. Here, the authors mapped the wastewater virome from 62 cities worldwide to identify over 2,500 viruses, revealing city-specific virome fingerprints and showing that wastewater metagenomics enables early detection of emerging viruses.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Talin is a mechanosensing cytoplasmic adaptor that links integrin cell adhesion receptors to the actin cytoskeleton. Here the authors measure the force-dependent folding and refolding kinetics of all talin rod domains to propose that talin can function as a force buffer under physiologically relevant conditions.

The number of ligand binding sites in the dopamine transporter is enigmatic due to conflicting data from structures and molecular pharmacology. Here, force spectra reveal the position and dynamics of a previously invisible transient site.

A manufacturable platform for quantum computing with photons is introduced and a set of monolithically integrated silicon-photonics-based modules is benchmarked, demonstrating dual-rail photonic qubits with performance close to thresholds required for operation.

DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening avenues for the treatment of blood disorders.

An interconnect based on a low-loss detachable cable connection between two superconducting qubit devices can be used to create elementary quantum networks of interchangeable superconducting quantum devices.

A juvenile iguanodontian from the Lower Cretaceous of China preserves both spikes and scales in its skin that are different from integumentary structures in either non-avian dinosaurs or extant squamates and may have had a defensive function.

By coupling two quantum dots via a superconductor-semiconductor hybrid region in a 2D electron gas, the authors achieve efficient splitting of Cooper pairs. Further, by applying a magnetic field perpendicular to the spin-orbit field, they can induce and measure large triplet correlations in the Cooper pair splitting process.

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.