Nature Search

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

Observation of glioblastoma invasion in subcortical brain regions is challenging. Here the authors develop a Deep3P workflow to enable longitudinal deep imaging of glioblastoma and its microenvironment by combining three-photon microscopy and deep learning-based analysis, unraveling the invasion routes of these tumor cells into and within the white matter.

Marc Cicero Schubert
Stella Judith Soyka
Varun Venkataramani
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-21
Publisher Correction: Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Yves Zurbuchen
Jan Michler
Onur Boyman
Amendments and CorrectionsOpen Access21 Aug 2023
Nature Immunology

Volume: 24, P: 1961
Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Boyman and colleagues perform phenotypic and B cell receptor sequencing analysis of memory B cell subsets in severe acute respiratory syndrome coronavirus 2-infected and subsequently vaccinated individuals up to 1 year post-infection to show that single memory B cell clones can adopt different trajectories.

Yves Zurbuchen
Jan Michler
Onur Boyman
ResearchOpen Access27 Apr 2023
Nature Immunology

Volume: 24, P: 955-965
Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8⁺ T cell activation and limit responsiveness to immunotherapy in mice

Cancer-associated fibroblasts (CAFs) are abundant in the stroma of pancreatic ductal carcinoma (PDAC) tumors. In this study, the authors demonstrate using human samples and mouse models that senescent CAFs impair CD8⁺ T cell responses and may contribute to poor responsiveness to immunotherapy in PDAC.

Benjamin Assouline
Rachel Kahn
Ittai Ben-Porath
ResearchOpen Access22 Jul 2024
Nature Communications

Volume: 15, P: 1-16
275 HCG-PERGONAL INDUCED TESTICULAR FUNCTIONS IN A HYPOPI TUITARY MAN FOLLOWING A DECADE OF TESTOSTERONE Rx

Thomas Aceto Jr.
Larry E Patterson
J Michael McMillin
Research01 Apr 1978
Pediatric Research

Volume: 12, P: 409
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Genetic variants associated with susceptibility to pancreatic cancer have been identified using genome wide association studies (GWAS). Here, the authors combine data from over 9000 patients and perform a meta-analysis to identify five novel loci linked to pancreatic cancer.

Alison P. Klein
Brian M. Wolpin
Laufey T. Amundadottir
ResearchOpen Access08 Feb 2018
Nature Communications

Volume: 9, P: 1-11
Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma

Lucy X. Ma
Yifan Wang
Grainne M. O’Kane
Research16 Mar 2023
British Journal of Cancer

Volume: 128, P: 1916-1921
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

Rainer Spanagel
Gurudutt Pendyala
Urs Albrecht
Research19 Dec 2004
Nature Medicine

Volume: 11, P: 35-42
Three-photon microscopy: an emerging technique for deep intravital brain imaging

Optical microscopy allows neural cells to be studied in the intact brain, but imaging deep neural tissue presents substantial challenges. Prevedel and colleagues outline the principles of three-photon microscopy, highlighting its advantages for deep tissue imaging and its applications in neuroscience.

Robert Prevedel
Júlia Ferrer Ortas
Varun Venkataramani
Reviews20 Jun 2025
Nature Reviews Neuroscience

Volume: 26, P: 521-537
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Whole-genome sequencing, transcriptome sequencing and single-cell analysis of primary and metastatic pancreatic adenocarcinoma identify molecular subtypes and intratumor heterogeneity.

Michelle Chan-Seng-Yue
Jaeseung C. Kim
Faiyaz Notta
Research13 Jan 2020
Nature Genetics

Volume: 52, P: 231-240
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

Expression of HNF1A and KRT81 stratifies pancreatic ductal adenocarcinoma tumors into different subtypes, and expression of cytochrome P450 3A5 mediates basal and/or drug-induced therapy resistance in each subtype.

Elisa M Noll
Christian Eisen
Martin R Sprick
Research08 Feb 2016
Nature Medicine

Volume: 22, P: 278-287
A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Felix Stickel and colleagues report the results of a genome-wide association study of alcohol-related cirrhosis. They confirm PNPLA3 as a susceptibility locus and identify new association signals in MBOAT7 and TM6SF2.

Stephan Buch
Felix Stickel
Jochen Hampe
Research19 Oct 2015
Nature Genetics

Volume: 47, P: 1443-1448
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Alison Klein and colleagues report a genome-wide meta-analysis to identify loci associated with pancreatic cancer risk. They identify associated variants at 17q25.1, 3q29, 7p13 and 2p13.3.

Erica J Childs
Evelina Mocci
Alison P Klein
Research22 Jun 2015
Nature Genetics

Volume: 47, P: 911-916
Sinonasal mucosal melanoma treatment response assessment to immune checkpoint inhibitors using hybrid positron emission tomography imaging

Alexander Maurer
Nathalie A. Gstrein
Christian M. Meerwein
ResearchOpen Access01 Nov 2023
Scientific Reports

Volume: 13, P: 1-11
Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad morphological spectrum and high MYB::NFIB prevalence

Tina Mauthe
Christian M. Meerwein
Niels J. Rupp
ResearchOpen Access12 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

Li Liu
Shanshan Han
Ingrid Herr
ResearchOpen Access19 Dec 2022
Cell Death & Disease

Volume: 13, P: 1-15
Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

Joan Miguel Romero
Emma Titmuss
George Zogopoulos
ResearchOpen Access09 Aug 2023
npj Precision Oncology

Volume: 7, P: 1-14
XRCC5 as a Risk Gene for Alcohol Dependence: Evidence from a Genome-Wide Gene-Set-Based Analysis and Follow-up Studies in Drosophila and Humans

Dilafruz Juraeva
Jens Treutlein
Marcella Rietschel
Research18 Jul 2014
Neuropsychopharmacology

Volume: 40, P: 361-371
Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Renato Polimanti
Raymond K. Walters
Joel Gelernter
Research26 Feb 2020
Molecular Psychiatry

Volume: 25, P: 1673-1687
SNP- and Haplotype Analysis of the Tryptophan Hydroxylase 2 Gene in Alcohol-Dependent Patients and Alcohol-Related Suicide

Peter Zill
Ulrich W Preuss
Michael Soyka
Research24 Jan 2007
Neuropsychopharmacology

Volume: 32, P: 1687-1694
αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior

Alanna C Easton
Walter Lucchesi
Christian P Müller
Research04 Mar 2013
Neuropsychopharmacology

Volume: 38, P: 1636-1647
Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies

Felicia Kamp
Lisa Proebstl
Joseph Kambeitz
Reviews27 Aug 2018
Neuropsychopharmacology

Volume: 44, P: 660-667

Search

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis

Publisher Correction: Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8⁺ T cell activation and limit responsiveness to immunotherapy in mice

275 HCG-PERGONAL INDUCED TESTICULAR FUNCTIONS IN A HYPOPI TUITARY MAN FOLLOWING A DECADE OF TESTOSTERONE Rx

Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer

Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

Three-photon microscopy: an emerging technique for deep intravital brain imaging

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis

Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer

Sinonasal mucosal melanoma treatment response assessment to immune checkpoint inhibitors using hybrid positron emission tomography imaging

Outcome-oriented clinicopathological reappraisal of sinonasal adenoid cystic carcinoma with broad morphological spectrum and high MYB::NFIB prevalence

Glucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy

Chemokine expression predicts T cell-inflammation and improved survival with checkpoint inhibition across solid cancers

XRCC5 as a Risk Gene for Alcohol Dependence: Evidence from a Genome-Wide Gene-Set-Based Analysis and Follow-up Studies in Drosophila and Humans

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

SNP- and Haplotype Analysis of the Tryptophan Hydroxylase 2 Gene in Alcohol-Dependent Patients and Alcohol-Related Suicide

αCaMKII Autophosphorylation Controls the Establishment of Alcohol Drinking Behavior

Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies

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