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Showing 1–21 of 21 results
Advanced filters: Author: Michael J. Krashes Clear advanced filters

  • Rapid, minimally invasive control of explicit neural activity would be a major advance for basic and clinical research in the neuroscience and neuroendocrinology fields, and could have applications for the potential treatment of neurological disorders. A new study by Stanley et al. brings us closer to this goal.

    • Samuel C. Funderburk
    • Michael J. Krashes
    News & Views
    Nature Reviews Endocrinology
    Volume: 12, P: 316-317

  • Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

    • Ivan C. Alcantara
    • Chia Li
    • Michael J. Krashes
    Research
    Nature
    Volume: 645, P: 981-990

    • Marco Bassetto
    • Thomas Reichl
    • Henrik Mouritsen
    ResearchOpen Access
    Nature
    Volume: 629, P: E6-E7

  • Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense hunger.

    • Christopher M. Mazzone
    • Jing Liang-Guallpa
    • Michael J. Krashes
    Research
    Nature Neuroscience
    Volume: 23, P: 1253-1266

  • Hypothalamic Agouti-related peptide (AgRP) neurons play a key role in regulating food intake. Here, the authors report a novel pathway in which activation of Gs-coupled receptors on AgRP neurons leads to robust, sustained increase in food intake.

    • Ken-ichiro Nakajima
    • Zhenzhong Cui
    • Jürgen Wess
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Disturbances in internal water equilibrium can be debilitating for mammals. Two studies pinpoint areas of the mouse brain that respond to and anticipate thirst, preserving systematic fluid regulation. See Letters p.680 & p.685

    • Michael J. Krashes
    News & Views
    Nature
    Volume: 537, P: 626-627

  • Hypothalamic Agouti-related peptide (AgRP)-expressing neurons promote feeding via inhibitory mechanisms. A downstream target in the medial amygdala both mediates feeding and modulates risk-taking and defensive behaviors in the face of starvation.

    • Chia Li
    • Michael J Krashes
    News & Views
    Nature Neuroscience
    Volume: 19, P: 645-646

  • AgRP neurons of the arcuate nucleus of the hypothalamus promote homeostatic feeding yet are rapidly suppressed by food-related sensory cues. The authors identify a population of inhibitory DMH-LepR neurons that relays real-time information about the nature and availability of food to dynamically modulate ARC-AgRP neuron activity and feeding behavior.

    • Alastair S Garfield
    • Bhavik P Shah
    • Bradford B Lowell
    Research
    Nature Neuroscience
    Volume: 19, P: 1628-1635

  • Melanocortin 4 receptors (MC4Rs) are critical to the promotion of homeostatic satiety. The authors established paraventricular hypothalamus (PVH) MC4R-expressing neurons as a functional target for orexigenic arcuate nucleus agouti-related peptide–expressing neurons and identify an explicit PVH MC4R-expressing neuron to lateral parabrachial nucleus satiety-promoting circuit, the activation of which encodes positive valence in calorically depleted mice.

    • Alastair S Garfield
    • Chia Li
    • Bradford B Lowell
    Research
    Nature Neuroscience
    Volume: 18, P: 863-871

  • In response to food cues, a hypothalamic circuit in the mouse brain transiently inhibits neurons expressing agouti-related peptide, and this promotes learning of cue-initiated food-seeking tasks.

    • Janet Berrios
    • Chia Li
    • Bradford B. Lowell
    Research
    Nature
    Volume: 595, P: 695-700

  • BRS3 is a receptor regulating energy metabolism. The authors find that DMH Brs3 neurons control body temperature, energy expenditure, and heart rate, but not food intake. In contrast, PVH Brs3 neurons regulate food intake but not energy expenditure.

    • Ramón A. Piñol
    • Sebastian H. Zahler
    • Marc L. Reitman
    Research
    Nature Neuroscience
    Volume: 21, P: 1530-1540

  • Asprosin, a recently identified secreted hormone from adipose tissue, acts centrally to promote food intake.

    • Clemens Duerrschmid
    • Yanlin He
    • Atul R Chopra
    Research
    Nature Medicine
    Volume: 23, P: 1444-1453

  • The AgRP-expressing neurons in the arcuate nucleus drive food-seeking behaviours during caloric restriction; a mouse study of monosynaptic retrograde rabies spread and optogenetic circuit mapping reveals that these neurons are activated by input from hypothalamic paraventricular nucleus cells and their activation or inhibition can modulate feeding behaviour.

    • Michael J. Krashes
    • Bhavik P. Shah
    • Bradford B. Lowell
    Research
    Nature
    Volume: 507, P: 238-242

  • Central melanocortinergic signaling via the melanocortin-4 receptor is both a culprit in and a target for obesity. The authors review our understanding of this evolutionarily conserved system in the regulation of mammalian energy homeostasis.

    • Michael J Krashes
    • Bradford B Lowell
    • Alastair S Garfield
    Reviews
    Nature Neuroscience
    Volume: 19, P: 206-219

  • Dopamine is synonymous with reward in mammals but associated with aversive reinforcement in insects, where reward seems to be signalled by octopamine; here it is shown that flies have discrete populations of dopamine neurons representing positive or negative values that are coordinately regulated by octopamine.

    • Christopher J. Burke
    • Wolf Huetteroth
    • Scott Waddell
    Research
    Nature
    Volume: 492, P: 433-437