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Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

An 11-qubit atom processor comprising two precision-placed nuclear spin registers of phosphorus in silicon is shown to achieve state-of-the-art Bell-state fidelities of up to 99.5%.

A new platform comprising large-scale 2D arrays of quantum dots patterned with sub-nanometre precision, with each quantum dot defined by tens of phosphorus atoms doped into silicon, allows for analogue simulation of quantum materials on arbitrary lattices.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

A four-qubit processor of three phosphorus nuclear spins and an electron spin in silicon enables the implementation of a three-qubit Grover’s search algorithm with 95% fidelity. The implementation is based on an advanced multi-qubit gate with single-qubit gate fidelities above 99.9% and two-qubit gate fidelities above 99%.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Donor spin states in silicon are good quantum bit candidates due to their long coherence times. Here, the authors use radio frequency reflectometry to measure singlet and triplet states, and to determine the tunnel coupling between few-donor silicon double quantum dots and the electrical leads.

The spin of an electron bound to a single phosphorus atom in silicon is of interest for spin-based electronics such as quantum computing. Here, Büch et al. show these spin properties are retained even for clusters of a few phosphorus atoms, providing an additional means for quantum bit addressability.

Multi-donor molecules in Si provide a promising qubit platform, offering advantages over single donor qubits in terms of performance and fabrication. Here, the authors report a single qubit gate and long coherence times in a P donor molecule qubit in natural Si patterned by scanning tunneling microscope hydrogen lithography.

Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneous, and they identify a novel recurrent amplification of MYCL1.

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Spin qubits in systems with strong spin–orbit coupling can be electrically controlled, but are usually affected by short coherence times. Here, coherence times up to 10 ms are obtained for strain-engineered hole states bound to boron acceptors in silicon 28.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

A phosphorus dopant qubit is positioned within a vertically gated single-electron transistor with <5 nm alignment precision and its spin is read with 97.9% fidelity.

Electron spin qubits in semiconductors show great promise, but fast, high-fidelity readout remains challenging. Here, by precisely engineering the location of two multi-donor quantum dot qubits in silicon, the authors demonstrate high-fidelity latched parity readout with reduced integration time, even at elevated temperatures.

The intercalated disc (ICD) is a membrane structure of the cardiac muscle involved in normal heart function. Here the authors report that knockdown of the ICD-bound transmembrane protein 65 results in impaired ICD structure, abnormal cardiac electrophysiology and cardiomyopathy in mice.

A more comprehensive understanding of coupled quantum systems could soon be in reach with a capacitance-based scanning probe technique that explores the behaviour and interaction of individual dopant atoms in a semiconductor.

By controlling the density of phosphorus dopant atoms in single-crystal silicon it is possible to fabricate quantum dots that do not contain interfaces between different materials.

Exchange coupling can be observed in a two-donor system in silicon, opening the way to operations involving two qubits

An electric dipole spin resonance protocol making use of hyperfine interaction enacts high-fidelity initialization of a four-qubit nuclear spin register in silicon. This protocol allows for high-fidelity qubit control and a path towards a register-based quantum computer using the exceptional coherence properties of donors in silicon.

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.

Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13⁺ T_PH/T_FH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

Precision-engineered devices consisting of a linear array of ten quantum dots are used to realize both the trivial and topological phases of the many-body Su–Schrieffer–Heeger model.

PIEZO1 is a mechanosensitive ion channel. Here, authors identify PIEZO1 human mutations in Prune Belly Syndrome. At a single molecule level these mutations exhibit loss-of-function characteristics.

A single phosphorus atom is deterministically positioned between source, drain and gate electrodes within an epitaxial silicon device architecture to make a single-atom transistor.

Understanding the tumor microenviroment is important before it can be exploited therapeutically. Here, the authors use single cell sequencing to study stromal cells in mouse tumors and identify a subset of interferon-licensed cancer associated fibroblasts that appear after anti-TGFβ treatment.

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Fungi from the Neocallimastigomycetes taxonomic class break bonds in lignin during the anaerobic deconstruction of whole plant cell walls. This finding challenges the paradigm that only certain aerobic organisms break down lignin.

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Donor impurities in silicon are promising candidates as qubits but in order to create a large-scale quantum computer inter-qubit coupling must be introduced by precise positioning of the donors. Here the authors demonstrate the fabrication, manipulation and readout of a two qubit phosphorous donor device.

A 25-year-old question about whether a two-dimensional system can be a real metal at low temperatures and in zero magnetic field has recently been answered positively. A new link between this unusual metallic behaviour and the quantum Hall effect (observed at high magnetic fields) suggests that they share a common physical origin.

High-resolution subnational mapping of child growth failure indicators for 105 low- and middle-income countries between 2000 and 2017 shows that, despite considerable progress, substantial geographical inequalities still exist in some countries.

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

The genome of the gibbon, a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes, is presented, providing insights into the evolutionary history of gibbon species and their accelerated karyotypes, as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees.

Era+ breast cancer patients often develop resistance to endocrine therapy. Here, the authors show that FGFR1 amplification is a resistance mechanism to CDK4/6 inhibitor and endocrine therapy and that combined treatment with FGFR, CDK4/6, and anti-estrogens is a potential therapeutic strategy in Era+ breast cancer tumors.

Germline mono-allelic loss of the tumour suppressor NF1 predisposes patients to the development of benign lesions but rarely further progression into cancer development. Here the authors use mouse models to show that an NF1 heterozygous microenvironment accelerates the formation of benign tumours but impairs progression to malignancy.

A fast, high-fidelity two-qubit exchange gate between phosphorus donor electron spin qubits in silicon is demonstrated by creating a tunable exchange interaction between two electrons bound to phosphorus atom qubits.

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

Whole-genome analysis of oestrogen-receptor-positive tumours in patients treated with aromatase inhibitors show that distinct phenotypes are associated with specific patterns of somatic mutations; however, most recurrent mutations are relatively infrequent so prospective clinical trials will require comprehensive sequencing and large study populations.

Jayavelu, Samaha et al., apply machine learning models on hospital admission data, including antibody titers and viral load, to identify patients at high risk for Long COVID. Low antibody levels, high viral loads, chronic diseases, and female sex are key predictors, supporting early, targeted interventions.