Nature Search

A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice

The complement cascade is increasingly recognized in the brain. Here, with MERFISH, the authors showed developmentally regulated brain endogenous expression of complement genes and a potential role of the alternative pathway in brain development.

Yingying Zhang
Brianna Watson
Michael C. Carroll
ResearchOpen Access02 Dec 2025
Nature Communications

Volume: 16, P: 1-15
WDR4 drives tumour-associated macrophage reprogramming and tumour progression via selective translation and membrane cholesterol efflux

J. Liu, C. Qu, Y. Liu and colleagues report an m⁷G-independent function of WDR4 in regulating translation machinery and cholesterol homeostasis in tumour-associated macrophages. They develop a targeting strategy using CpG-small interfering RNA to suppress tumour progression.

Jie Liu
Chengming Qu
Yufeng Yuan
Research28 Nov 2025
Nature Cell Biology

Volume: 27, P: 2152-2166
A hybrid machine learning-enhanced MCDM model for transport safety engineering

Xingjian Zhang
Haowen Chen
Faan Chen
ResearchOpen Access20 Oct 2025
Scientific Reports

Volume: 15, P: 1-27
Experimental study on concrete expansion performance and cracking time under SCDA pressure using DOFS technology

Minghe Liu
ResearchOpen Access28 Nov 2025
Scientific Reports

Volume: 15, P: 1-10
Reliability analysis of gear-bearing drive systems considering gear manufacturing and installation errors

Jinzhou Song
Yifan Wang
Yushu Chen
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-17
Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis

Streptovaricin C is an antibiotic containing a methylenedioxy bridge (MDB) moiety essential for its activity. Here, the authors show that a P450 monooxygenase StvP2 catalyses MDB formation, report its crystal structure in complex with the substrate, and elucidate mechanistic details of MDB formation.

Guo Sun
Chaoqun Hu
Yuhui Sun
ResearchOpen Access09 Sept 2020
Nature Communications

Volume: 11, P: 1-12
Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma

Tianyin Ma
Wing-Wa Guo
Yufeng Yuan
ResearchOpen Access15 May 2025
Cell Death & Disease

Volume: 16, P: 1-14
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth

Yuan et al. demonstrate that cancer-associated fibroblasts in the pancreatic tumor microenvironment secrete nucleosides through autophagy in an NUFIP1-dependent manner, thereby inducing glucose consumption under glutamine-deprived conditions and promoting tumor growth.

Meng Yuan
Bo Tu
Ying Zhao
Research18 Aug 2022
Nature Cancer

Volume: 3, P: 945-960
Red teaming ChatGPT in medicine to yield real-world insights on model behavior

Crystal T. Chang
Hodan Farah
Roxana Daneshjou
ResearchOpen Access07 Mar 2025
npj Digital Medicine

Volume: 8, P: 1-10
Unprecedented non-hysteretic superelasticity of [001]-oriented NiCoFeGa single crystals

NiCoFeGa single crystals exhibit large non-hysteretic superelasticity over broad temperature and composition ranges. It is attributed to the continuous phase transition with applied stress, which is related to the fluctuation of entangled ordered and disordered crystal structures.

Haiyang Chen
Yan-Dong Wang
Yang Ren
Research16 Mar 2020
Nature Materials

Volume: 19, P: 712-718
An optimized deterministic concurrency control approach for geo-distributed transaction processing on permissioned blockchains

Zhibo Han
Zeshun Peng
Ge Yu
ResearchOpen Access02 Jun 2025
Scientific Reports

Volume: 15, P: 1-11
Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9

Yi-ying Chou
Annabel Krupp
Tom Kirchhausen
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-11

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