The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5+ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.
- Yutiantian Lei
- Rui Jia
- Yuzhu Hou