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Showing 1–50 of 51 results

Advanced filters: Author: Mingliang Ye Clear advanced filters

Real-time AI-assisted quality control during nasopharyngolaryngoscopy: a randomized controlled trial

Yun Li
Bin Ye
Mingliang Xiang
ResearchOpen Access16 Apr 2026
npj Digital Medicine

P: 1-12
Solvent-induced partial cellular fixation decodes proteome-wide drug targets and downstream pathways in living cells

Understanding drug targets and their effects in living cells is challenging. Here, the authors develop SICFA, a label-free proteomics method that sensitively detects drug-induced protein stability changes, thereby identifying targets and downstream pathways directly in living cells.

Ting Yu
Yan Wang
Mingliang Ye
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-16
A maize wall-associated kinase confers quantitative resistance to head smut

Mingliang Xu and colleagues show that a wall-associated kinase, ZmWAK, confers resistance to maize head smut, a systemic fungal disease in maize.

Weiliang Zuo
Qing Chao
Mingliang Xu
Research22 Dec 2014
Nature Genetics

Volume: 47, P: 151-157
Library-based virtual match-between-runs quantification in GlyPep-Quant improves site-specific glycan identification

The poor interpretation of glycopeptide spectra limits the site-specific glycan quantification at the proteomics scale. Here, the authors develop GlyPep-Quant, a glycopeptide quantification tool using library-based match-between-runs strategy, to enhance coverage of site-specific glycan analysis.

He Zhu
Zheng Fang
Mingliang Ye
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Origin and stepwise evolution of vertebrate lungs

An analysis of single-cell RNA sequencing data from adult and developing lungs across vertebrate species reveals genetic components in the common ancestor of jawed vertebrates and new lung-specific enhancers that contribute to the evolution of vertebrate lungs.

Ye Li
Mingliang Hu
Kun Wang
Research14 Feb 2025
Nature Ecology & Evolution

Volume: 9, P: 672-691
Metabolic labeling based methylome profiling enables functional dissection of histidine methylation in C3H1 zinc fingers

Here the authors developed a methyl-specific metabolic labeling approach for global analysis covering diverse methylation types. His methylation is found in C3H1 zinc fingers. U2AF1 is used to highlight the role of His methylation in ZFs in RNA metabolism.

Keyun Wang
Li Zhang
Mingliang Ye
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Proximity proteomics reveals OTUD6B regulation of stress granule dynamics through coalescence with VCP/p97

Dian Yang
Yichao Liu
Han Liu
ResearchOpen Access06 Feb 2026
Cell Death & Disease

Volume: 17, P: 1-15
Single-cell analysis of the amphioxus hepatic caecum and vertebrate liver reveals genetic mechanisms of vertebrate liver evolution

Comparative analysis of single-cell data from the amphioxus hepatic caecum and the liver of several vertebrates shows how genome duplication contributes to cellular diversification and functional complexity of the vertebrate liver.

Baosheng Wu
Wenjie Xu
Kun Wang
Research16 Aug 2024
Nature Ecology & Evolution

Volume: 8, P: 1972-1990
Correction: Corrigendum: A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

Zhiwei Zhu
Sufang Zhang
Zongbao K. Zhao
Amendments and Corrections29 Jul 2013
Nature Communications

Volume: 4, P: 1
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands

The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.

Kejia Li
Shijie Chen
Mingliang Ye
Research10 Dec 2024
Nature Methods

Volume: 22, P: 278-282
A multicenter clinical AI system study for detection and diagnosis of focal liver lesions

Early detection and accurate diagnosis of focal liver lesions are crucial for effective treatment and prognosis. Here, the authors present a fully automated diagnostic system that leverages multi-phase CT scans and clinical features, for diagnosing liver lesions.

Hanning Ying
Xiaoqing Liu
Xiujun Cai
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Protein digestion priority is independent of protein abundances

Mingliang Ye
Yanbo Pan
Hanfa Zou
Correspondence27 Feb 2014
Nature Methods

Volume: 11, P: 220-222
Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation

Poor peptide fragmentation and unusual glycan structures limit mass spectrometry-based analysis of intact N-glycopeptides. Here, the authors develop Glyco-Decipher, a glycan-independent peptide search tool, to tackle these issues and improve the coverage of site-specific glycan analysis.

Zheng Fang
Hongqiang Qin
Mingliang Ye
ResearchOpen Access07 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

In a randomized placebo-controlled trial in 37 individuals with excess body weight, dietary supplementation with resistant starch lowers body weight and induces changes in gut microbiota composition. Mechanistic analysis in male mice shows that resistant starch at least partially facilitates weight loss through the action of Bifidobacterium adolescentis.

Huating Li
Lei Zhang
Weiping Jia
ResearchOpen Access26 Feb 2024
Nature Metabolism

Volume: 6, P: 578-597
Genome-wide patterns of genetic variation among elite maize inbred lines

Jun Wang and colleagues report the resequencing of six elite maize inbred lines. The authors identified over 1 million SNPs and 30,000 insertion or deletion polymorphisms in this agricultural crop.

Jinsheng Lai
Ruiqiang Li
Jun Wang
Research24 Oct 2010
Nature Genetics

Volume: 42, P: 1027-1030
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK

A small-molecule aldolase inhibitor, aldolazin is reported and shown to selectively activate the lysosomal pool of AMPK, which has glucose-lowering effects in rodents.

Chen-Song Zhang
Mengqi Li
Sheng-Cai Lin
ResearchOpen Access10 Oct 2022
Nature Metabolism

Volume: 4, P: 1369-1401
Cytokine changes in clinical high risk for psychosis population following antipsychotic medication

YanYan Wei
LiHua Xu
TianHong Zhang
ResearchOpen Access07 Jan 2026
Translational Psychiatry

Volume: 16, P: 1-9
The Role of Interactions between Halloysite Nanotubes and 2,2′-(1,2-Ethenediyldi-4,1-phenylene) Bisbenzoxazole in Halloysite Reinforced Polypropylene Composites

Mingxian Liu
Baochun Guo
Demin Jia
Research18 Aug 2008
Polymer Journal

Volume: 40, P: 1087-1093
5-IP₇ is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis

Syt7-dependent pancreatic insulin release is shown to be mediated by 5-IP₇ in response to parasympathetic stimulation of the GPCR M3R.

Xiaozhe Zhang
Na Li
Feng Rao
Research18 Oct 2021
Nature Metabolism

Volume: 3, P: 1400-1414
Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder

A SH2-domain-derived superbinder that exhibits strong affinity for phosphotyrosine (pTyr) was used in conjugation with mass spectroscopy approaches to enrich and enable identification of pTyr sites in different cancer cell lines.

Yangyang Bian
Lei Li
Hanfa Zou
Research19 Sept 2016
Nature Chemical Biology

Volume: 12, P: 959-966
Bidirectional decision analysis of online Ride-hailing enterprises based on fuzzy theory and cloud model

Mingliang Yu
Gengsheng Zhao
Dongping Pu
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-26
Substantial halogenated organic chemicals stored in permafrost soils on the Tibetan Plateau

Chemical analyses show permafrost soils on the Tibetan Plateau contain large amounts of halogenated organic chemicals that could be remobilized in a changing climate.

Xiaojing Zhu
Fan Yang
Jan Schwarzbauer
Research23 Oct 2023
Nature Geoscience

Volume: 16, P: 989-996
Small-sample learning reveals propionylation in determining global protein homeostasis

The development of a new smallsample learning framework, KprFunc, leads to the discovery of an important role for lysine propionylation in determining global protein homeostasis, mediated by a critical propionylation site on histone H2B, H2BK17pr.

Ke Shui
Chenwei Wang
Yu Xue
ResearchOpen Access17 May 2023
Nature Communications

Volume: 14, P: 1-23
Low-dose metformin targets the lysosomal AMPK pathway through PEN2

The molecular target of the antidiabetic medicine metformin is identified as PEN2, a subunit of γ-secretases, and the PEN2–ATP6AP1 axis offers potential targets for screening for metformin substitutes.

Teng Ma
Xiao Tian
Sheng-Cai Lin
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 159-165
Ultrathin Polyaniline-based Buffer Layer for Highly Efficient Polymer Solar Cells with Wide Applicability

Wenchao Zhao
Long Ye
Jianhui Hou
ResearchOpen Access10 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

The ability of oleaginous fungi to produce lipids for biofuels remains untapped, in part due to a lack of genetic information required to engineer industrial strains. Zhuet al. present the genome of R. toruloides, and identify transcriptomic and proteomic changes associated with lipid production.

Zhiwei Zhu
Sufang Zhang
Zongbao K. Zhao
ResearchOpen Access09 Oct 2012
Nature Communications

Volume: 3, P: 1-12
Hydrogen bond based smart polymer for highly selective and tunable capture of multiply phosphorylated peptides

Capture of low-abundance multiply phosphorylated peptides (MPPs) is difficult due to limitation of enrichment materials and their interactions with phosphates. Here the authors show, a smart polymer driven by specific but tunable hydrogen bonding interactions can differentially complex with MPPs, singly phosphorylated and non-modified peptides.

Guangyan Qing
Qi Lu
Taolei Sun
ResearchOpen Access06 Sept 2017
Nature Communications

Volume: 8, P: 1-12
Scale transformation of place brands: a visual study of Xinhepu, Guangzhou

Jiayin Zhang
Mingliang Lin
Yinbin Lin
ResearchOpen Access10 Nov 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-12
Estrogen receptor beta in lateral habenula mediates antidepressant effects of estrogen in postpartum-hormone-withdrawal-induced depression

Chenchi Duan
Shuangshuang Ma
He-Feng Huang
ResearchOpen Access05 Sept 2025
Molecular Psychiatry

Volume: 31, P: 296-308
Integrative multi-omics and drug–response characterization of patient-derived prostate cancer primary cells

Ziruoyu Wang
Yanan Li
Yongjun Dang
ResearchOpen Access01 May 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-16
Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

Zhenlong Yu
Jian Gao
Xiaochi Ma
ResearchOpen Access09 Mar 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-13
Robust phosphoproteome enrichment using monodisperse microsphere–based immobilized titanium (IV) ion affinity chromatography

Houjiang Zhou
Mingliang Ye
Shabaz Mohammed
Protocols07 Feb 2013
Nature Protocols

Volume: 8, P: 461-480
GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78

Jing Song
Wenwen Liu
Qi Wang
ResearchOpen Access11 May 2020
Cell Death & Disease

Volume: 11, P: 1-14
Targeting TRPV1-mediated autophagy attenuates nitrogen mustard-induced dermal toxicity

Mingliang Chen
Xunhu Dong
Zhongmin Zou
ResearchOpen Access25 Jan 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13
Global Screening of CK2 Kinase Substrates by an Integrated Phosphoproteomics Workflow

Yangyang Bian
Mingliang Ye
Hanfa Zou
ResearchOpen Access10 Dec 2013
Scientific Reports

Volume: 3, P: 1-7
A peptide N-terminal protection strategy for comprehensive glycoproteome analysis using hydrazide chemistry based method

Junfeng Huang
Hongqiang Qin
Hanfa Zou
ResearchOpen Access11 May 2015
Scientific Reports

Volume: 5, P: 1-15
A bead-based cleavage method for large-scale identification of protease substrates

Chunli Wang
Mingliang Ye
Hanfa Zou
ResearchOpen Access03 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Author Correction: π-HuB: the proteomic navigator of the human body

Fuchu He
Ruedi Aebersold
Zemin Zhang
Amendments and Corrections23 Dec 2024
Nature

Volume: 637, P: E22
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis

Deji Ye
Hanshao Liu
Xiaoren Zhang
ResearchOpen Access27 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-13
Research on action behavior of neuron system in case of single pulse stimulus

Mingliang Zhang
Menghua Man
Shanghe Liu
ResearchOpen Access27 Jan 2020
Scientific Reports

Volume: 10, P: 1-15
Lipid-related FABP5 activation of tumor-associated monocytes fosters immune privilege via PD-L1 expression on Treg cells in hepatocellular carcinoma

Jin Liu
Binwen Sun
Liming Wang
Research28 Jul 2022
Cancer Gene Therapy

Volume: 29, P: 1951-1960
π-HuB: the proteomic navigator of the human body

We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human biology.

Fuchu He
Ruedi Aebersold
Zemin Zhang
Reviews11 Dec 2024
Nature

Volume: 636, P: 322-331
A Comprehensive Video Dataset for Surgical Laparoscopic Action Analysis

Zi Ye
Ru Zhou
Mingliang Wang
ResearchOpen Access24 May 2025
Scientific Data

Volume: 12, P: 1-10
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma

Yu Tian
Bo Tang
Liming Wang
ResearchOpen Access05 Jul 2021
Cell Death & Disease

Volume: 12, P: 1-11
Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

Zhenlong Yu
Jian Gao
Xiaochi Ma
Amendments and CorrectionsOpen Access04 Sept 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1
Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer

Xi Chen
Chen Wang
Xiaoren Zhang
ResearchOpen Access01 May 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-12
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity

Lei Bai
Yongliang Zhao
Ke Xu
Research18 Feb 2021
Cell Research

Volume: 31, P: 395-403
Pwp1 regulates telomere length by stabilizing shelterin complex and maintaining histone H4K20 trimethylation

Yangyang Yu
Wenwen Jia
Jiuhong Kang
ResearchOpen Access05 Nov 2019
Cell Discovery

Volume: 5, P: 1-18
Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1

Chang-Liang He
Yang-Yang Bian
Wei Xu
ResearchOpen Access15 Feb 2016
Scientific Reports

Volume: 6, P: 1-14
Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis

Xi Chen
Xinwei Cao
Xiaoren Zhang
ResearchOpen Access01 Dec 2016
Cell Death & Disease

Volume: 7, P: e2508

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