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Showing 1–7 of 7 results
Advanced filters: Author: Morteza Rezanejad Clear advanced filters

  • Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy.

    • Mark Sorin
    • Morteza Rezanejad
    • Logan A. Walsh
    ResearchOpen Access
    Nature
    Volume: 614, P: 548-554

  • The spatial architecture of the lung cancer microenvironment could influence the survival outlook and therapeutic options of patients. Here the authors find distinct patterns and composition of immune cells when comparing lung adenocarcinomas and lung squamous cell carcinomas, paving way for precision immune therapy according to histological subtype.

    • Lysanne Desharnais
    • Mark Sorin
    • Logan A. Walsh
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Histone H3-mutant gliomas are deadly brain tumours and the tumour microenvironment is not fully understood. Here the authors profile the immune microenvironment from human samples and mouse models and implicate myeloid cells in immune suppression and show inhibition of myeloid cells and checkpoint blockade demonstrates therapeutic benefits in mice.

    • Augusto Faria Andrade
    • Alva Annett
    • Nada Jabado
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Imaging mass cytometry of human brain tumours provides spatial information that, combined with existing transcriptomic data, reveals the existence of a cellular neighbourhood containing a rare macrophage population associated with prolonged survival.

    • Elham Karimi
    • Miranda W. Yu
    • Logan A. Walsh
    ResearchOpen Access
    Nature
    Volume: 614, P: 555-563