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Showing 1–17 of 17 results
Advanced filters: Author: Myriam Heiman Clear advanced filters
  • Amyotrophic Lateral Sclerosis is characterized by TDP-43 proteinopathy in the brain. Here, the authors find TDP-43 aggregation might be mediated by the loss of Asparaginase-like 1, an enzyme that degrades detrimental isoaspartates and is downregulated by the endogenous retrovirus HML-2.

    • Marta Garcia-Montojo
    • Saeed Fathi
    • Avindra Nath
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24
  • By integrating large-scale genomic and proteomic data in cerebrospinal fluid and plasma, the authors identify 49 proteins linked to MRI markers of cerebral small vessel disease, highlighting extracellular matrix and immune pathways, with biomarker and therapeutic potential.

    • Ilana Caro
    • Daniel Western
    • Stéphanie Debette
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 2514-2531
  • Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP levels using a genome-wide CRISPRi screen and organellar metabolomics, with insights into congenital sideroblastic anemia.

    • Izabella A. Pena
    • Jeffrey S. Shi
    • Myriam Heiman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.

    • Sophia M. Shi
    • Ryan J. Suh
    • Tony Wyss-Coray
    ResearchOpen Access
    Nature
    Volume: 639, P: 985-994
  • Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.

    • Huixin Xu
    • Ryann M. Fame
    • Maria K. Lehtinen
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16
  • A study describes single-cell characterization of the human cerebrovasculature, revealing human-specific transcriptomic signatures and providing insights into transcriptional changes associated with Huntington’s disease.

    • Francisco J. Garcia
    • Na Sun
    • Myriam Heiman
    Research
    Nature
    Volume: 603, P: 893-899
  • A circuit in the amygdala uses thyrotropin-releasing hormone to suppress male mating when a female mouse is unhealthy.

    • Jeong-Tae Kwon
    • Changhyeon Ryu
    • Gloria B. Choi
    Research
    Nature
    Volume: 593, P: 114-118
  • Parkinson’s disease and L-DOPA-induced dyskinesia are both associated with imbalances in activity between populations of spiny projection neurons. Fieblinger et al.show that homeostatic adaptations in excitability are engaged by these disease states, but synaptic strengths are not scaled accordingly.

    • Tim Fieblinger
    • Steven M. Graves
    • D. James Surmeier
    Research
    Nature Communications
    Volume: 5, P: 1-15
  • On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • Myriam Heiman
    • Anne Schaefer
    Comments & Opinion
    Nature Neuroscience
    Volume: 22, P: 1203-1204
  • Identifying gene subsets affecting disease phenotypes from transcriptome data is challenge. Here, the authors develop a method that combines transcriptional data with disease ordinal clinical measurements to discover a sphingolipid metabolism regulator involving in Huntington’s disease progression.

    • Leila Pirhaji
    • Pamela Milani
    • Ernest Fraenkel
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13
  • This review provides an overview of analysis and experimental design of single-cell omics in the brain, emphasizing epigenomics and spatial omics. The authors discuss how the computational and experimental designs are interlinked, with both being guided by the biological questions.

    • Boyan Bonev
    • Gonçalo Castelo-Branco
    • Tomasz J. Nowakowski
    Reviews
    Nature Neuroscience
    Volume: 27, P: 2292-2309