Search

Comparison of spontaneous canine cancers and human cancers may illuminate future therapeutic avenues. Here, genomic analyses of these tumors highlights a convergence on PI3K-Akt oncogenic pathways.

Sensing internal body states is crucial for physiological homeostasis. Here, the authors show that the C. elegans PIEZO channel regulates swallowing by detecting intestinal food buildup and triggering pharyngeal movements to aid ingestion.

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

Reduction of carbon dioxide is promising for the production of value-added chemicals, but electrocatalysts are hindered by carbon monoxide poisoning. Here, the authors alternate reduction and oxidation potentials to achieve stable and selective long-term electrocatalytic reduction of carbon dioxide to formate.

Here the authors merge spatiotemporal modulation LED device, precise control and efficient polarization emission and programmable patterning/positioning using 3D printing demonstrating encryption in visible light communication (VLC) enabled by polarization state modulation.

Despite the potential of nanoparticles in facilitating cascade reactions in living organisms, precisely tuning each reaction within complex networks to enhance the catalytic activity is challenging. Here, the authors report a strategy to optically control each stage of cascade enzymatic reaction using chiral plasmonic nanoparticles under right- and left-handed circularly polarized light.

The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.

HIF-1α is a pivotal protein involved in angiogenesis and is known to be regulated posttranslationally. Here, the authors show that HIF-1α is methylated by Set7/9 methyltransferase, which reduces protein stability and contributes to reduced angiogenesis.

Metal-free neural electrodes enable simultaneous electrophysiological recording and optical imaging but often face challenges in impedance reduction. Here, Kim et al. develop a fully metal-free PEDOT:PSS neural interface with ultra-low impedance, high transparency, and compatibility with two-photon imaging.

An array of 2D crystals of isotropic, 432-symmetric chiral gold nanoparticles is shown to exhibit collective resonances with a strong and uniform chiral near field, allowing enantioselective detection by the collective circular dichroism.

Developing active and stable atomically dispersed catalysts is challenging because of weak non-specific interactions between catalytically active metal atoms and supports. A general method for synthesizing these catalysts via photochemical defect tuning for controlling oxygen-vacancy dynamics is proposed.

Nakamura and colleagues show selective ion transport through mineral nanochannels in submarine hydrothermal vent (HV) precipitates, enabling HVs to convert ionic gradients into electrochemical energy, similar to cellular systems

Transfer printing of inorganic semiconductors is essential for high-performance flexible electronics. Here, Park et al. report the micro-vacuum assisted selective transfer to integrate inorganic thin-film semiconductors on unusual substrates.

A hard X-ray self-seeded X-ray free-electron laser at the Pohang Accelerator Laboratory provides X-ray pulses with peak brightness of 3.2 × 10³⁵ photons s^–1 mm^–2 mrad^–2 0.1%BW^–1 at 9.7 keV and a very small shot-to-shot electron energy jitter of 0.012%.

Arrays of bioresorbable, highly doped silicon electrodes with multiplexing capabilities are used as electrocorticography sensors to perform in vivo, reliable acute and chronic recordings for up to one month before dissolving in the body.

The modification of protein and peptide therapeutics with tannic acid improves their ability to specifically target heart tissue, as shown with a rat model of myocardial ischaemia-reperfusion injury.

The facile synthesis of the 432 helicoid III nanoparticle morphology, displaying a Kuhn’s dissymmetry factor (g-factor) of 0.2, is detailed by using l-glutathione in an aqueous solution.

Electrochemical reduction of CO₂ can generate fuel precursors and additives, yet the set of possible products and overall efficiency are limited. Now, Lee et al. exploit redox-neutral reactions to form dimethyl carbonate from CO₂ in methanol with 60% Faradaic efficiency and extend the scheme to diethyl carbonate.

One challenge with using circularly polarized light is an increased device complexity typically required to provide sufficient sensitivity to the polarization. Here, by integrating chiral plasmonic nanoparticles with a InGaZnO hot electron transistor, the authors present a polarization sensitive, optically active transistor.

Researchers demonstrate nonlinear Compton scattering in a strong laser field, in which a laser-accelerated multi-GeV electron scatters off hundreds of laser photons and converts them into a single gamma-ray photon with several-hundred-MeV energy.

Electrochemical CO₂ mitigation involves two main approaches: capture and release, or direct conversion. Here, the authors report a method that integrates both by converting CO₂ into ethylene carbonate using electrochemically activated substrates.

Reversible and cooperative activation processes are important characteristics of biological enzymes and can be used in designing catalysts. Highly active TiO₂ photocatalysts incorporated with site-specific single copper atoms are now shown to exhibit such a photoactivation process.

Understanding reaction intermediates provides a foundation for active electrocatalysts’ design, but it remains elusive for heterogeneous electrocatalysts. Here, the authors report the spectroscopic characterization of low-spin Mn(IV)-oxo as the active intermediates during electrochemical water oxidation.

Type I CRISPR-Cas systems require a target-searching Cascade complex and the Cas3 degradation machine to drive prokaryotic adaptation to alien nucleic acids. Cas3 crystal structures now reveal the mechanism of concerted DNA unwinding and degradation.

Macromolecular complexes hold promise for future generations of drug delivery carriers, but probing their structures with high resolution is challenging. Here, the authors combine X-ray free-electron laser and synchrotron approaches to reveal the core-shell structure of RNA interference microsponges.

Glacial melt can modify heat transport, and therefore ocean processes, associated with ice front retreat, as revealed by direct observations from the Pine Island Bay region of Antarctica.

Laser-driven proton acceleration has faced a persistent 100-MeV energy barrier hindering its broader applications. Here, authors achieved the acceleration of protons beyond 110 MeV with an ultrahigh-contrast multi-petawatt laser pulse and a conduction-restricted nm-thick polymer foil.

During the influenza pandemic, a large number of deaths resulted from secondary bacterial pneumonia caused by common upper respiratory tract bacteria, such as Staphylococcus. Here, Moon et al, find that the interaction between airway epithelial CD47 and the pathogenic bacterial FnBP is critical in causing bacterial superinfection.