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Showing 1–50 of 103 results

Advanced filters: Author: Naoki Ikeda Clear advanced filters

Photooxidative Copper(II) Catalysis for Promoting anti-Markovnikov Hydration of Alkenes

Alkene hydration provides an atom-economical and redox-neutral route to aliphatic alcohols yet controlling regioselectivity remains challenging. Here, the authors reveal that a photooxidative heteroleptic copper(II) complex enables efficient anti-Markovnikov hydration of alkenes.

Naoki Oku
Keito Fuke
Tomoya Miura
ResearchOpen Access21 Feb 2026
Nature Communications

Volume: 17, P: 1-9
Geriatric nutritional risk index in antifibrotic therapy can predict tolerability and mortality risk

Takuya Masuda
Yasutaka Mochizuka
Takafumi Suda
ResearchOpen Access01 Apr 2026
Scientific Reports

P: 1-10
Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability

Phytic acid chelates essential minerals, reducing their bioavailability in cereal-based diets. This study proposes a scalable, species-independent chemical approach that targets myo-inositol 3-phosphate synthase 1 (INO1), a key enzyme in phytic acid biosynthesis, to lower its levels in rice and wheat without affecting plant growth or yield.

Tatsuki Akabane
Satoshi Kamino
Naoki Hirotsu
ResearchOpen Access04 Feb 2026
Nature Food

Volume: 7, P: 163-173
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant

Ikeda et al. report that HLA-DRB1 can serve as a leukemia-specific target for CAR T or natural killer cell-based therapy in patients with AML after allogeneic hematopoietic stem cell transplantation.

Shunya Ikeda
Kana Hasegawa
Naoki Hosen
Research24 Mar 2025
Nature Cancer

Volume: 6, P: 595-611
Effect of Cytogenin, a Novel Immunomodulator, on Streptozotocin-induced Diabetes in Mice

Hiroyuki Kumagai
Kuniko Wakazono
Daishiro Ikeda
Research01 Mar 2005
The Journal of Antibiotics

Volume: 58, P: 202-205
Serum interferon-λ3 as a short-term biomarker of disease control in anti-MDA5-positive dermatomyositis-associated ILD

Yoshihiro Kitahara
Tomoyuki Fujisawa
Takafumi Suda
ResearchOpen Access24 Jan 2026
Scientific Reports

Volume: 16, P: 1-10
Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer

Desmoplastic stroma is a hallmark of aggressive colorectal cancer. Matrix cancer-associated fibroblasts derived THBS2 establishes a fibrotic, immune-exclusionary barrier that limits CD8⁺ T cell infiltration, while its inhibition restores CXCR3-mediated T cell recruitment and enhances response to immune checkpoint blockade.

Kosuke Iwane
Yuki Nakanishi
Hiroshi Seno
ResearchOpen Access23 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Evidence for Shared Genetic Risk Between Methamphetamine-Induced Psychosis and Schizophrenia

Masashi Ikeda
Yuko Okahisa
Nakao Iwata
Research12 Apr 2013
Neuropsychopharmacology

Volume: 38, P: 1864-1870
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Correction to: Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma

Nobuyoshi Takeshita
Isamu Hoshino
Hisahiro Matsubara
Amendments and Corrections26 Aug 2024
British Journal of Cancer

Volume: 131, P: 1106
Structure and Filtration Performances of Improved Cuprammonium Regenerated Cellulose Hollow Fiber (Improved BMM Hollow Fiber) for Virus Removal

Takashi Tsurumi
Tetsuo Sato
Naoki Yamamoto
Research01 Dec 1990
Polymer Journal

Volume: 22, P: 1085-1100
A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS

A genome-wide association study in Japanese patients with ALS identifies rs113161727 at the ADAM29-GPM6A locus as a modifier of age at onset and links it to GPM6A upregulation.

Ryoichi Nakamura
Genki Tohnai
Gen Sobue
ResearchOpen Access05 Dec 2025
Communications Biology

Volume: 8, P: 1-11
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice

A KIM-1–AIM interaction promotes clearance of cellular debris in renal tubules after acute kidney injury to improve disease outcome.

Satoko Arai
Kento Kitada
Toru Miyazaki
Research04 Jan 2016
Nature Medicine

Volume: 22, P: 183-193
Deep learning-based detection of retinal detachment with vitreous hemorrhage in ocular ultrasound images

Naoki Toyama
Takako Hidaka
Yasuhiro Ikeda
ResearchOpen Access11 Feb 2026
Scientific Reports

Volume: 16, P: 1-11
Inclusion Complex Formation of Cyclodextrin with Large Dye Molecule

Hidefumi Hirai
Naoki Toshima
Satoshi Uenoyama
Research01 Jun 1981
Polymer Journal

Volume: 13, P: 607-610
The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer

Whole-transcriptome sequencing of a subset of 75 non-small-cell lung cancer specimens in a multi-institutional genome screening study identified a fusion of the CLIP1 and LTK genes with transformational potential due to constitutive LTK kinase activity.

Hiroki Izumi
Shingo Matsumoto
Koichi Goto
Research24 Nov 2021
Nature

Volume: 600, P: 319-323
Mechanism of Removing Japanese Encephalitis virus (JEV) and Gold Particles Using Cuprammonium Regenerated Cellulose Hollow Fiber (i-BMM or BMM) from Aqueous Solution Containing Protein

Tomoko Hirasaki
Toshiaki Noda
Naoki Yamamoto
Research01 Nov 1994
Polymer Journal

Volume: 26, P: 1244-1256
A prospective cohort study of periostin as a serum biomarker in patients with idiopathic pulmonary fibrosis treated with nintedanib

Masaki Okamoto
Kiminori Fujimoto
Tomoaki Hoshino
ResearchOpen Access27 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Ultrafast evolution of photonic eigenstates in k-space

Rob J. P. Engelen
Yoshimasa Sugimoto
L. (Kobus) Kuipers
Research01 Apr 2007
Nature Physics

Volume: 3, P: 401-405
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

Maria-Céu Moreira
Clara Barbot
Michel Koenig
Research01 Oct 2001
Nature Genetics

Volume: 29, P: 189-193
Association between parental decisions regarding abortion and severity of fetal heart disease

Masahiro Nakao
Masanari Kuwabara
Tomoaki Ikeda
ResearchOpen Access01 Jul 2024
Scientific Reports

Volume: 14, P: 1-8
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Prehospital predicting factors using a decision tree model for patients with witnessed out-of-hospital cardiac arrest and an initial shockable rhythm

Kazuya Tateishi
Yuichi Saito
Hiroyuki Okura
ResearchOpen Access27 Sept 2023
Scientific Reports

Volume: 13, P: 1-8
Regional variation in pre-dialysis blood pressure and its association with cardiovascular mortality rates in Japanese patients undergoing dialysis

At the prefectural level, pre-dialysis SBP is higher than 140 mmHg in Japanese patients undergoing dialysis, especially higher in those with DKD.

Hirofumi Sakuma
Minori Ikeda
Naoki Nakagawa
Research15 Sept 2023
Hypertension Research

Volume: 47, P: 102-111
The activated conformation of integrin β₇ is a novel multiple myeloma–specific target for CAR T cell therapy

Hosen et al. identify an active conformation of integrin beta-7 as a cancer-associated antigen in multiple myeloma, and engineer a CAR-T cell that shows efficacy against MM in a mouse model. These findings describe the first conformation-specific CAR-T cell and highlight the potential of conformational targets in cancer immunotherapy.

Naoki Hosen
Yukiko Matsunaga
Atsushi Kumanogoh
Research06 Nov 2017
Nature Medicine

Volume: 23, P: 1436-1443
Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.

Daisuke Doi
Hiroaki Magotani
Jun Takahashi
ResearchOpen Access06 Jul 2020
Nature Communications

Volume: 11, P: 1-14
Microcalorimetric Study of Aqueous Solution of a Thermoresponsive Polymer, poly(N-vinylisobutyramide) (PNVIBA)

Shigeru Kunugi
Tomoko Tada
Mitsuru Akashi
Research01 May 2002
Polymer Journal

Volume: 34, P: 383-388
Structure of Cuprammonium Regenerated Cellulose Hollow Fiber (BMM Hollow Fiber) for Virus Removal

Takashi Tsurumi
Naoki Osawa
Takashi Yamashiki
Research01 Aug 1990
Polymer Journal

Volume: 22, P: 751-758
Mechanism of Removing Monodisperse Gold Particles from a Suspension Using Cuprammonium Regenerated Cellulose Hollow Fiber (BMM Hollow Fiber)

Takashi Tsurumi
Naoki Osawa
Takashi Yamashiki
Research01 Apr 1990
Polymer Journal

Volume: 22, P: 304-311
Thermoresponsive Organic–Inorganic Polymer Hybrids from Poly(N-isopropylacrylamide)

Yusuke Imai
Naoki Yoshida
Yoshiki Chujo
Research01 Mar 1999
Polymer Journal

Volume: 31, P: 258-262
New silica clathrate minerals that are isostructural with natural gas hydrates

Clathrates are minerals with cage-like structural voids that can be filled by guest species; three types are plausible but only one has been observed in nature. Mommaet al. have discovered the remaining two types in Japanese marine sediments, and determined their structural similarity to natural gas hydrates.

Koichi Momma
Takuji Ikeda
Yasuhiro Kudoh
Research15 Feb 2011
Nature Communications

Volume: 2, P: 1-7
A pristine record of outer Solar System materials from asteroid Ryugu’s returned sample

The sample taken from carbonaceous asteroid Ryugu and brought back to Earth by the Hayabusa2 spacecraft contains outer Solar System-derived materials uncontaminated by terrestrial processes. Even CI carbonaceous chondrites, despite their closeness to solar abundances, are not pristine.

Motoo Ito
Naotaka Tomioka
Yuichi Tsuda
ResearchOpen Access15 Aug 2022
Nature Astronomy

Volume: 6, P: 1163-1171
Elastocaloric determination of the phase diagram of Sr₂RuO₄

The phase diagram of the unconventional superconductor Sr₂RuO₄ in both normal and superconducting states is mapped out using high-precision measurements of the elastocaloric effect, showing similarities to other unconventional superconductors as well as unique features.

You-Sheng Li
Markus Garst
Andrew P. Mackenzie
ResearchOpen Access13 Jul 2022
Nature

Volume: 607, P: 276-280
New evidence of arsenic translocation and accumulation in Pteris vittata from real-time imaging using positron-emitting ⁷⁴As tracer

Yi Huang-Takeshi Kohda
Zhaojie Qian
Chihiro Inoue
ResearchOpen Access08 Jul 2021
Scientific Reports

Volume: 11, P: 1-10
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output

Ryosuke Ikeda
Yoshiki Tsuchiya
Kazuhiro Yagita
ResearchOpen Access15 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Isohumulones Derived from Hops Ameliorate Renal Injury via an Anti-Oxidative Effect in Dahl Salt-Sensitive Rats

Tamehachi Namikoshi
Naruya Tomita
Naoki Kashihara
Research01 Feb 2007
Hypertension Research

Volume: 30, P: 175-184
Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine

Converting serine to pyruvate and ammonia, serine racemase is shown to support colon-cancer growth, thus highlighting a new strategy that cancer cells use to maintain cellular pyruvate levels and mitochondrial mass.

Kenji Ohshima
Satoshi Nojima
Eiichi Morii
Research13 Jan 2020
Nature Metabolism

Volume: 2, P: 81-96
A Quasi-Solid State DSSC with 10.1% Efficiency through Molecular Design of the Charge-Separation and -Transport

Michio Suzuka
Naoki Hayashi
Hiroyuki Nishide
ResearchOpen Access17 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Selective Deposition of SiO₂ on Ion Conductive Area of Soda-lime Glass Surface

Daisuke Sakai
Kenji Harada
Junji Nishii
ResearchOpen Access13 Jun 2016
Scientific Reports

Volume: 6, P: 1-7
Mu rhythm suppression reflects mother-child face-to-face interactions: a pilot study with simultaneous MEG recording

Chiaki Hasegawa
Takashi Ikeda
Mitsuru Kikuchi
ResearchOpen Access10 Oct 2016
Scientific Reports

Volume: 6, P: 1-8
Elastic and dynamical structural properties of La and Mn-doped SrTiO₃ studied by neutron scattering and their relation with thermal conductivities

Ryoichi Kajimoto
Mitsutaka Nakamura
Tetsuji Okuda
ResearchOpen Access25 Jun 2018
Scientific Reports

Volume: 8, P: 1-8
First demonstration of multi-color 3-D in vivo imaging using ultra-compact Compton camera

Aya Kishimoto
Jun Kataoka
Jun Hatazawa
ResearchOpen Access18 May 2017
Scientific Reports

Volume: 7, P: 1-7
Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling

Tomoya Nakamura
Naoki Yoshida
Yoshihiko Kojima
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-15
Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment

Yusei Yamada
Mayuko Tanaka
Yoichi Ishitsuka
ResearchOpen Access22 Aug 2025
Scientific Reports

Volume: 15, P: 1-10
Estimation of Base Blood Pressure by Using a New Device in the Outpatient Clinic

Osamu Tochikubo
Naoki Kura
Kiyoko Nishijima
Research01 Apr 2006
Hypertension Research

Volume: 29, P: 233-241
Differential brain volume between obese and underweight cognitively normal older adults with frailty in the JPSC-AD

Naoki Ishizuka
Hiroshi Akasaka
Yutaka Kiyohara
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-12
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.

Naomi Tsuburaya
Kengo Homma
Hidenori Ichijo
ResearchOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1-12
Relationship between age-related hearing loss and alcohol consumption in a Japanese population

Hiyori Takahashi
Jun Suzuki
Yukio Katori
ResearchOpen Access02 Dec 2025
Scientific Reports

Volume: 16, P: 1-25

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