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Showing 1–50 of 61 results

Advanced filters: Author: Naoki Sugimoto Clear advanced filters

Carnitine Metabolism in Valproate-Treated Rats: The Effect of L-Carnitine Supplementation

Naoki Nishida
Tateo Sugimoto
Yohnosuke Kobayashi
Research01 Nov 1987
Pediatric Research

Volume: 22, P: 500-503
Response to: Study of Left Ventricular Long Axis Function in Patients with Hypertensive Response to Exercise

Takeshi Takamura
Katsuya Onishi
Masaaki Ito
Correspondence01 Jul 2008
Hypertension Research

Volume: 31, P: 1485-1486
Mechanical gate control for atom-by-atom cluster assembly with scanning probe microscopy

Nanoclusters supported on substrates are important for a range of applications, as well as of interest for their fundamental physics and chemistry. Here, the authors demonstrate the use of a scanning probe microscope for the assembly of nanoclusters on an atom-by-atom basis.

Yoshiaki Sugimoto
Ayhan Yurtsever
Seizo Morita
Research11 Jul 2014
Nature Communications

Volume: 5, P: 1-7
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Mechanical insights into ribosomal progression overcoming RNA G-quadruplex from periodical translation suppression in cells

Tamaki Endoh
Naoki Sugimoto
ResearchOpen Access07 Mar 2016
Scientific Reports

Volume: 6, P: 1-8
The efficacy of contrast-enhanced harmonic endoscopic ultrasonography in diagnosing gallbladder cancer

Mitsuru Sugimoto
Tadayuki Takagi
Hiromasa Ohira
ResearchOpen Access10 May 2016
Scientific Reports

Volume: 6, P: 1-6
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2

The EphA2 receptor tyrosine kinase is overexpressed in many cancers and is reported to be phosphorylated by Akt. Here, Zhou et al.show that RSK, rather than Akt, phosphorylates EphA2 on Ser-897, and this regulates cell migration and invasion of metastatic cancer cells.

Yue Zhou
Naoki Yamada
Hiroaki Sakurai
ResearchOpen Access09 Jul 2015
Nature Communications

Volume: 6, P: 1-12
Inhibition of glycolysis and stimulation of mitochondrial biogenesis lead to increased ROS levels and cell death in HNF-1ß positive clear cell carcinoma

Naoki Kawahara
Hiroki Kuniyasu
Fuminori Kimura
ResearchOpen Access01 Dec 2025
Cell Death & Disease

Volume: 16, P: 1-10
Publisher Correction: High-energy long-cycling all-solid-state lithium metal batteries enabled by silver–carbon composite anodes

Yong-Gun Lee
Satoshi Fujiki
In Taek Han
Amendments and Corrections20 Mar 2020
Nature Energy

Volume: 5, P: 348
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Patients with a Hypertensive Response to Exercise Have Impaired Left Ventricular Diastolic Function

Takeshi Takamura
Katsuya Onishi
Masaaki Ito
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 257-263
High-energy long-cycling all-solid-state lithium metal batteries enabled by silver–carbon composite anodes

Solid-state Li metal batteries represent one of the most promising rechargeable battery technologies. Here the authors report an exceptional high-performance prototype solid-state pouch cell made of a sulfide electrolyte, a high-Ni layered oxide cathode and, in particular, a silver–carbon composite anode with no excess Li.

Yong-Gun Lee
Satoshi Fujiki
In Taek Han
Research09 Mar 2020
Nature Energy

Volume: 5, P: 299-308
Thermal Polymerization of 1,2-Dithiane

Kiyoshi Endo
Tomotsugu Shiroi
Naoki Murata
Research12 Jul 2005
Polymer Journal

Volume: 37, P: 512-516
Haploinsufficiency of NSD1 causes Sotos syndrome

Naohiro Kurotaki
Kiyoshi Imaizumi
Naomichi Matsumoto
Research18 Mar 2002
Nature Genetics

Volume: 30, P: 365-366
An anionic phthalocyanine decreases NRAS expression by breaking down its RNA G-quadruplex

Hyperactivity of the gene NRAS contributes to the proliferation and metastatic nature of many types of cancer cells. Here, the authors show that NRAS can be controlled by an anionic phthalocyanine coordinating Zn²⁺ in combination with photo-irradiation.

Keiko Kawauchi
Wataru Sugimoto
Daisuke Miyoshi
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD⁺ biosynthesis and thermogenesis in mice

Kiyoshi Yoshioka
Takumi Sugimoto
Shin-ichiro Imai
ResearchOpen Access24 Nov 2025
npj Aging

Volume: 11, P: 1-8
Creation of magnetic skyrmions by surface acoustic waves

The controlled creation of magnetic skyrmions is a prerequisite for their application in future spintronic devices. While charge currents can induce skyrmions via spin torque, surface acoustic waves can do the same through magnetoelastic coupling of inhomogeneous strain paired with thermal fluctuations.

Tomoyuki Yokouchi
Satoshi Sugimoto
Yoshichika Otani
Research30 Mar 2020
Nature Nanotechnology

Volume: 15, P: 361-366
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy

Yuta Yamada
Yoichi Fujii
Haruki Kume
ResearchOpen Access31 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Clinical outcomes of patients with remitting ulcerative colitis after discontinuation of indigo naturalis

Fumie Shimada
Yusuke Yoshimatsu
Takanori Kanai
ResearchOpen Access09 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis

Patients with primary sclerosing cholangitis (PSC) harboring Klebsiella pneumoniae (Kp) exhibit poor clinical outcomes. Here, the authors show that administration of a phage cocktail targeting PSC-derived Kp reduces bacterial burden in Kp-colonized mice and alleviates liver injury.

Masataka Ichikawa
Nobuhiro Nakamoto
Takanori Kanai
ResearchOpen Access05 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Ultrafast evolution of photonic eigenstates in k-space

Rob J. P. Engelen
Yoshimasa Sugimoto
L. (Kobus) Kuipers
Research01 Apr 2007
Nature Physics

Volume: 3, P: 401-405
Predictability of environment-dependent formation of G-quadruplex DNAs in human mitochondria

Molecular crowding varies spatio-temporally in cells, affecting the stability of nucleic acids and inducing their non-canonical structures. However, the exact behavior of nucleic acids in local cellular environments remains unclear. Here, the authors report guanine-quadruplex (G4) DNA formation in the environment specific to human mitochondria and demonstrate repression of gene expression by G4 formation in mitochondria.

Lutan Liu
Shuntaro Takahashi
Naoki Sugimoto
ResearchOpen Access03 May 2025
Communications Chemistry

Volume: 8, P: 1-9
AtPHT4;4 is a chloroplast-localized ascorbate transporter in Arabidopsis

In plants, ascorbate is synthesized in the mitochondria yet plays essential roles as an antioxidant in the chloroplast. Here, Miyaji et al.show that AtPHT4;4 is a chloroplast envelope ascorbate transporter and suggest it is required for dissipation of excess energy under light stress.

Takaaki Miyaji
Takashi Kuromori
Yoshinori Moriyama
ResearchOpen Access05 Jan 2015
Nature Communications

Volume: 6, P: 1-11
The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer

Mitsuru Sugimoto
Kazumichi Abe
Hiromasa Ohira
ResearchOpen Access19 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer

Mitsuru Sugimoto
Tadayuki Takagi
Hiromasa Ohira
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-6
Specific Light-Up System for Protein and Metabolite Targets Triggered by Initiation Complex Formation

Hiroto Fujita
Yuka Kataoka
Masayasu Kuwahara
ResearchOpen Access09 Nov 2017
Scientific Reports

Volume: 7, P: 1-8
Capability of tip-growing plant cells to penetrate into extremely narrow gaps

Naoki Yanagisawa
Nagisa Sugimoto
Yoshikatsu Sato
ResearchOpen Access03 May 2017
Scientific Reports

Volume: 7, P: 1-7
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase
Takumi Hirata
Masayuki Yamamoto
ResearchOpen Access13 Aug 2025
Hypertension Research

Volume: 48, P: 2606-2617
Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins

In vivo, in vitro and in silico experiments demonstrate that interface residues of homomeric proteins are enriched toward protein C termini to avoid premature assembly and aggregation.

Eviatar Natan
Tamaki Endoh
Sarah A. Teichmann
Research12 Feb 2018
Nature Structural & Molecular Biology

Volume: 25, P: 279-288
Derived neutrophil-to-lymphocyte ratio has the potential to predict safety and outcomes of durvalumab after chemoradiation in non-small cell lung cancer

Akira Sugimoto
Hiroyasu Kaneda
Tomoya Kawaguchi
ResearchOpen Access23 Aug 2024
Scientific Reports

Volume: 14, P: 1-11
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells

Atsuho Morita
Makoto Ishii
Koichi Fukunaga
ResearchOpen Access23 Jun 2025
npj Regenerative Medicine

Volume: 10, P: 1-16
Altered exocrine function can drive adipose wasting in early pancreatic cancer

Pancreatic ductal adenocarcinoma in mice induces loss of adipose tissue through altered function of the exocrine pancreas, and supplementing pancreatic enzymes attenuates the wasting of peripheral tissues induced by pancreatic cancer.

Laura V. Danai
Ana Babic
Matthew G. Vander Heiden
Research20 Jun 2018
Nature

Volume: 558, P: 600-604
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Pathways from eudaimonic and hedonic motives to life satisfaction via response style

Damee Choi
Motohiro Kimura
Toshihisa Sato
ResearchOpen Access02 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13–p12 in Japanese

Hajime Nawata
Senji Shirasawa
Takehiko Sasazuki
Research01 Nov 2004
Journal of Human Genetics

Volume: 49, P: 629-634
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
E-Cadherin and Cadherin-Associated Cytoplasmic Proteins Are Expressed in Murine Mast Cells

Tatsuya Tegoshi
Minoru Nishida
Naoki Arizono
Research01 Oct 2000
Laboratory Investigation

Volume: 80, P: 1571-1581
Theranostic approach to specifically targeting the interloop region of BCL2 i-motif DNA by crystal violet

Sinjan Das
Shuntaro Takahashi
Naoki Sugimoto
ResearchOpen Access01 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
Early detection of brain metastases and appropriate local therapy followed by systemic chemotherapy may improve the prognosis of gastric cancer

Yasunobu Ishizuka
Takeshi Omori
Toshihiro Kudo
ResearchOpen Access27 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Dielectricity of a molecularly crowded solution accelerates NTP misincorporation during RNA-dependent RNA polymerization by T7 RNA polymerase

Shuntaro Takahashi
Saki Matsumoto
Naoki Sugimoto
ResearchOpen Access21 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Preferential targeting cancer-related i-motif DNAs by the plant flavonol fisetin for theranostics applications

Shuntaro Takahashi
Snehasish Bhattacharjee
Sudipta Bhowmik
ResearchOpen Access13 Feb 2020
Scientific Reports

Volume: 10, P: 1-13
Relationship between dementia and gut microbiome-associated metabolites: a cross-sectional study in Japan

Naoki Saji
Kenta Murotani
Takashi Sakurai
ResearchOpen Access18 May 2020
Scientific Reports

Volume: 10, P: 1-11
High performance plasma amyloid-β biomarkers for Alzheimer’s disease

Measurement of human plasma amyloid-β biomarkers using immunoprecipitation coupled with mass spectrometry reliably predicts individual brain amyloid-β status and has potential clinical utility.

Akinori Nakamura
Naoki Kaneko
Katsuhiko Yanagisawa
Research31 Jan 2018
Nature

Volume: 554, P: 249-254
Author Correction: Small bandgap in atomically precise 17-atom-wide armchair-edged graphene nanoribbons

Junichi Yamaguchi
Hironobu Hayashi
Shintaro Sato
Amendments and CorrectionsOpen Access28 Jul 2020
Communications Materials

Volume: 1, P: 1
Comparable Stability of Hoogsteen and Watson–Crick Base Pairs in Ionic Liquid Choline Dihydrogen Phosphate

Hisae Tateishi-Karimata
Miki Nakano
Naoki Sugimoto
ResearchOpen Access08 Jan 2014
Scientific Reports

Volume: 4, P: 1-7

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