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Showing 1–15 of 15 results
Advanced filters: Author: Neeraj Dhaun Clear advanced filters

  • Genetic variants of TREX1, a negative regulator of type I interferon responses, have been linked previously to non-monogenic systemic lupus erythematosus (SLE). Here the authors analyze UK Biobank multi-omics data to show that, while a derived oligoprotein interferon signature associates with increased SLE risk, TREX1 variants do not.

    • Bastien Rioux
    • Sarah McGlasson
    • David P. J. Hunt
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-15

  • Disease-monitoring in large vessel vasculitis is challenging, often leading to a mismatch between disease activity and treatment intensity. Here, the authors show that PET/MRI scanning can distinguish active from inactive large vessel vasculitis and track disease longitudinally, potentially allowing more stratified treatment for patients.

    • Dan Pugh
    • Dilip Patel
    • Neeraj Dhaun
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • In patients with CKD, there is an unmet need for biomarkers that reliably track kidney injury. Here, in a series of prospective studies, the authors show that retinal OCT metrics reflect kidney injury, are modified by treatments for kidney disease and can predict future decline of kidney function.

    • Tariq E. Farrah
    • Dan Pugh
    • Neeraj Dhaun
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Endothelin 1 is the most potent vasoconstrictor in the human cardiovascular system. In this Review, Dhaun and Webb discuss the biology of the endothelins and endothelin receptors and how these pathways can be therapeutically targeted in cardiovascular and renal diseases.

    • Neeraj Dhaun
    • David J. Webb
    Reviews
    Nature Reviews Cardiology
    Volume: 16, P: 491-502

  • Hunter et al. use RNA labelling to investigate RNA transfer between organs in mice. They show that RNA potentially moves en masse from liver to kidney and that this movement is augmented in acute liver injury, although the physiological relevance of the phenomenon is not yet known.

    • Robert W. Hunter
    • Jialin Sun
    • James W. Dear
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Hypertension is the leading cause of death globally but has low rates of diagnosis and treatment. In this Review, Dhaun and colleagues discuss the reasons for poor control of hypertension, such as therapeutic inertia and poor patient adherence, as well as novel pharmacological approaches to blood pressure lowering.

    • Matthew Sayer
    • David J. Webb
    • Neeraj Dhaun
    Reviews
    Nature Reviews Cardiology
    Volume: 22, P: 649-663

  • Retinal microvascular changes are strongly linked to prevalent and incident cardiovascular disease. These changes can now be mapped with unparalleled accuracy using retinal optical coherence tomography. Novel retinal imaging, combined with the power of deep learning, might soon equip clinicians with unique and precise risk-assessment tools that enable truly individualized patient management.

    • Tariq E. Farrah
    • David J. Webb
    • Neeraj Dhaun
    Comments & Opinion
    Nature Reviews Cardiology
    Volume: 16, P: 379-381

  • In both focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN), kidney injury is characterised by the invasion of glomerular tufts by parietal epithelial cells (PECs). Here Lazareth et al. identify the tetraspanin CD9 as a key regulator of PEC migration, and find its upregulation in FSGS and CGN contributes to kidney injury in both diseases.

    • Hélène Lazareth
    • Carole Henique
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-17

  • Crescentic rapidly progressive glomerulonephritis is a severe form of glomerula disease characterized by podocyte proliferation and migration. Here Henique et al. demonstrate that inhibition of miRNA-92a prevents kidney failure by promoting the expression of CDK inhibitor p57Kip2 that regulates podocyte cell cycle.

    • Carole Henique
    • Guillaume Bollée
    • Pierre-Louis Tharaux
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Large-vessel vasculitis is the most common primary vasculitis in adults, manifesting as inflammation of the aorta and its major branches. This Primer reviews the epidemiology, pathophysiology, diagnosis and management of this disease, highlights its effects on patient quality of life, and discusses future research questions.

    • Dan Pugh
    • Maira Karabayas
    • Neeraj Dhaun
    Reviews
    Nature Reviews Disease Primers
    Volume: 7, P: 1-23

  • The apelin system is a broad regulator of physiology that has beneficial cardiovascular and renal effects. This Review focuses on the role of this system in kidney and cardiovascular health and disease and its potential as a therapeutic target.

    • Fiona A. Chapman
    • Duuamene Nyimanu
    • Neeraj Dhaun
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 840-853

  • Endothelin-1 (ET-1) is a potent vasoactive peptide that is produced by various cell types of the kidney and regulates a variety of physiological processes. This Review describes the role of ET-1 in the kidney and in the development of chronic kidney disease, and the kidney-protective effects of endothelin-receptor antagonists in preclinical and clinical studies.

    • J. David Smeijer
    • Donald E. Kohan
    • Hiddo J. L. Heerspink
    Reviews
    Nature Reviews Nephrology
    Volume: 21, P: 175-188

  • Here, the authors discuss the effects of salt intake on health outcomes, the factors that determine individual susceptibility to dietary salt and approaches to reducing salt intake and improving health at the population and individual levels.

    • Robert W. Hunter
    • Neeraj Dhaun
    • Matthew A. Bailey
    Reviews
    Nature Reviews Nephrology
    Volume: 18, P: 321-335