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Understanding the physics of charge density waves in emerging superconductors may reveal insights into unconventional superconductivity mechanisms. Here, the authors study the temperature and magnetic-field dependence of charge-density-wave suppression in the unconventional superconductor UTe₂.

Combining the infrared capabilities of JWST and synthetic tracking techniques, the detection of some of the smallest asteroids ever observed in the main belt is reported; their large abundance reveals a population driven by collisional cascade.

The accretion geometry of X-ray binary Cygnus X-3 is determined here from IXPE observations. X-ray polarization reveals a narrow funnel with reflecting walls, which focuses emission, making Cyg X-3 appear as an ultraluminous X-ray source.

Deuterated amines play a crucial role as building blocks in drug synthesis and in identifying metabolites of novel pharmaceuticals. This study introduces a dual-functional phosphorus-doped iron single-atom catalyst that efficiently enables both reductive amination and deuteration in a one-pot process, utilizing H₂ as the reducing agent and cost-effective D₂O as the deuterium source.

Upward electrical discharges from thunderstorms were discovered recently, and only a very limited set of observations exist because they are rare and unpredictable. Here, the authors present recordings of different types of the discharge above a storm, which contradict current theories of their origins.

Here, the authors present fossilized neural traits from the lower Cambrian euarthropod Jianfengia multisegmentalis, including structured eyestalks and compound eyes, that resolve multiple phylogenetic relationships within Euarthropoda.

Understanding the mechanisms of chemoresistance in multiple myeloma (MM) remains elusive. Here, the authors identify a long non-coding RNA termed as PLUM that is overexpressed in NF-ĸB mutant high-risk MM and interacts with EZH2 to mediate PRC2 complex formation promoting chemoresistance via the activation of the UPR pathway.

New field measurements and modeling show meltwater refreezing in Greenland’s bare ice may reduce runoff to surrounding oceans, highlighting a process climate models can incorporate for improved predictions of future sea-level rise.

Natural killer cells have important roles in virus and anti-cancer responses. Glimcher and colleagues demonstrate that a natural killer cell-intrinsic endoplasmic reticulum stress pathway is essential for their proper function.

The products and dynamics in mutual neutralisation of \({{{{\rm{O}}}}_{2}}^{+}\) with O⁻ occurring in atmospheric sprites are unknown. Here, the authors reveal a dissociative two-step mechanism via intermediate Rydberg states and a dependence on the \({{{{\rm{O}}}}_{2}}^{+}\) vibrational state.

Here, the authors identify mechanistic differences in the dependence on co-transcription factors between orthologous TFs from two related yeast species, S. cerevisiae and C. glabrata. The investigation into intrinsically disordered regions sheds light on the role of autoinhibition in the reliance on co-TFs.

Nanoscale environments created by topological defects in liquid crystals can template the self-assembly of molecular amphiphiles within the defects.

Here, the authors report on the fabrication of strained wrinkles in monolayer WSe₂ by placing the material on Au nanoconical substrates. They investigate the correlation between topographical stress factors and localised, quantum-dot-like photoluminescence emission.

Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir can reduce SARS-CoV-2 replication in patients.

Existing methods of zebrafish phenotyping rely on contact-based processes. Here the authors report on an acoustofluidic-based platform which performs contactless specimen rotation, that results in multispectral images for rapid morphological phenotyping of zebrafish larvae.

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

The role of glutamate-driven inhibition in neural computations and animal behavior is not fully understood. This study reveals that group III metabotropic glutamate receptors (mGluRs) mediate inhibition in the habenula, shaping sensory processing and defensive behaviors, highlighting a key role for glutamate-driven inhibition in the brain.

Californium is difficult to prepare in its divalent state. Now, crystals of a Cf(II) crown–ether complex have been synthesized by reduction of a Cf(III) precursor with an Al/Hg amalgam. They exhibit 5f→6d transitions in the visible region and near-infrared emission that are highly sensitive to changes in the coordination environment.

The experimental demonstration of a continuous and irreversible transfer of cold atoms from a ‘source mode’ to a ‘laser mode’ represents a step closer to a fully continuous atom laser.

A liquid-crystal-in-oil emulsion system exhibits bistable opacity or transparency, with rapid switching between the two, faster than, for example, electrochromics that can be found in smart windows.

Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein activation in response to soluble or cell-surface ligands, enabling control of diverse cellular behaviours.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

In this work, the authors report a system for production of short versions of a filamentous phage enables the structure to be determined by cryo-electron microscopy. Structure combined with mutagenesis allows the identification of phage domains that are important in bacterial attack and for release of new viral progeny.

JWST observations of a strongly lensed low-mass galaxy in a 600-million-year-old Universe show massive star clusters (the Firefly Sparkle) cocooned in a diffuse arc in the Canadian Unbiased Cluster Survey.

Singlet fission — the splitting of a singlet exciton into two triplets — is a process that could be exploited to improve the power conversion efficiency of solar cells. Spectroscopic data now suggest that coherent and incoherent mechanisms for singlet fission in crystalline hexacene coexist and occur on different timescales.

This work shows that receptor use in merbecovirus is clade-specific by clustering them into clades based on the receptor-binding domain (RBD) of their spike proteins. While MERS-CoV and its close relatives use the DPP4 receptor, several other clades—including all HKU5 bat coronaviruses—rely on ACE2, the same receptor used by SARS-CoV and SARS-CoV-2.

Excitatory neurons in the neocortex exhibit considerable morphological diversity, yet their organizational principles remain a subject of ongoing research. Here, the authors use unsupervised learning to show that most excitatory neuron morphologies in the mouse visual cortex form a continuum, with notable exceptions in deeper layers.

The MICrONS mouse visual cortex dataset shows that neurons with similar response properties preferentially connect, a pattern that emerges within and across brain areas and layers, and independently emerges in artificial neural networks where these ‘like-to-like’ connections prove important for task performance.

Understanding structure evolution during electrochemical growth is crucial in materials processing and design of devices such as batteries. Here, the authors image copper during electrodeposition to provide strategies for controlling interface morphology.

The metabolically driven maturation of geometrically aligned human cardiac microtissues on a microfabricated chip reduces cell-phenotype-dependent variabilities in the action-potential morphology and calcium handling of the cardiomyocytes.

Christopher Newton-Cheh and colleagues report a genome-wide association study for blood pressure traits as part of the Global BPgen consortium. They report eight loci with replicated association to systolic and/or diastolic blood pressure, with each also showing association to hypertension.

The quantum nature of light has been harnessed in a photonic chip to perform machine-learning tasks. For specifically designed problems, the approach outperforms established classical methods.

A principal component analysis of Cassini’s infrared spectral maps of Titan reveals the main features of Titan’s equatorial surface, effectively removing the obscuring atmospheric effects. A 6,300-kilometre-long strip of exposed icy bedrock—uncorrelated with topography or measurements of the subsurface—is visible, surrounded by organic deposits.

Prostate cancer is often a multifocal disease but how best to manage this clinically remains unclear. Here, the authors report a single case study of a patient with two genetically diverse tumours which showed differential response to therapy.

Circulating factors play an important role in tissue aging. Here, the authors show that serum EV subpopulations and cargoes remodel with age and that EVs from young mouse serum rejuvenate aged skeletal muscle.

The archaeological site Shinfa-Metema 1 in the lowlands of northwest Ethiopia provides early evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow.

Double Asteroid Redirection Test (DART) mission impact on asteroid Dimophos resulted in an elliptical ejecta plume. Here, the authors show that this elliptical ejecta is due to the curvature of the asteroid and makes kinetic momentum transfer less efficient.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms that the SegAB system employs to link chromosome organization to genome segregation.

Characterizing the internal architecture of zeolites is crucial for understanding their structure–function relationships, and for acid–base heterogeneous catalysis. Using a unique combination of diffraction and microscopy techniques provides a unified picture of the morphology of intergrowth structures and confirmation of surface barriers for molecular diffusion.

European agricultural subsidies are mainly allocated to rural regions where agriculture is intensified such as southern Europe, the Lowlands, and the Balkans, instead of Nordic and Central Europe which are more sustainable, according to a spatial hotspot analysis of 24 sustainability indicators