Nature Search

Use of Aspergillus Niger as a Test Organism for Determining Molybdenum Available in Soils to Crop Plants

D. J. D. NICHOLAS
A. H. FIELDING
Research26 Aug 1950
Nature

Volume: 166, P: 342-343
Utilization of Nitrate by Micro-organisms

C. A. FEWSON
D. J. D. NICHOLAS
Research01 Apr 1961
Nature

Volume: 190, P: 2-7
Rapid evolution of a highly efficient RNA polymerase by homologous recombination

Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. Using DNA shuffling and droplet microfluidics, the current study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity.

Esau L. Medina
Victoria A. Maola
John C. Chaput
Research07 Jan 2026
Nature Chemical Biology

P: 1-9
Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis

Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. The current study offers insights into the structural and biochemical changes responsible for improving the fidelity and catalytic activity of a laboratory evolved TNA polymerase.

Mohammad Hajjar
Victoria A. Maola
John C. Chaput
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-14
New Analeptics and Hypnotics related to the Barbiturate Antagonist, ‘Bemegride’

T. C. SOMERS
Research03 Nov 1956
Nature

Volume: 178, P: 996-997
Following replicative DNA synthesis by time-resolved X-ray crystallography

DNA polymerases are the key enzymes responsible for DNA replication and repair. Here the authors reveal through time-lapsed images of X-ray crystal structures that translocation precedes phosphodiester bond formation in the mechanism of DNA synthesis.

Nicholas Chim
Roman A. Meza
John C. Chaput
ResearchOpen Access11 May 2021
Nature Communications

Volume: 12, P: 1-8
Acetylation of Sugars

S. D. NICHOLAS
F. SMITH
Research06 Mar 1948
Nature

Volume: 161, P: 349
Cooperative effects in simulated water

P. Barnes
J. L. Finney
J. E. Quinn
Research01 Nov 1979
Nature

Volume: 282, P: 459-464
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

Genome-wide association analyses identify new risk loci for heart failure and its subtypes, extending understanding of the underlying biological pathways and disease mechanisms.

Albert Henry
Xiaodong Mo
R. Thomas Lumbers
ResearchOpen Access04 Mar 2025
Nature Genetics

Volume: 57, P: 815-828
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA

Danzhou Yang
Stella S. G. E. van Boom
Andrew H.-J. Wang
Research01 Jul 1995
Nature Structural Biology

Volume: 2, P: 577-586
A novel free-living prochlorophyte abundant in the oceanic euphotic zone

Sallie W. Chisholm
Robert J. Olson
Nicholas A. Welschmeyer
Research01 Jul 1988
Nature

Volume: 334, P: 340-343
Screening for Familial Hypercholesterolemia in 5000 Neonates: A Recall Study

Barbara L Blades
Nicholas P B Dudman
David E L Wilcken
Research01 May 1988
Pediatric Research

Volume: 23, P: 500-504
Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions

In this Review, Scott et al. review our current knowledge of Shigella sonnei, highlighting recent insights into this globally disseminated antimicrobial-resistant pathogen and assessing how novel data may have an impact on future vaccine development and implementation.

Timothy A. Scott
Kate S. Baker
Stephen Baker
Reviews27 Nov 2024
Nature Reviews Microbiology

Volume: 23, P: 303-317
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

Sonia Shah
Albert Henry
R. Thomas Lumbers
ResearchOpen Access09 Jan 2020
Nature Communications

Volume: 11, P: 1-12
Arylsulfatase B Deficiency in Maroteaux-Lamy Syndrome: Cellular Studies and Carrier Identification

Nicholas G Beratis
Bryan M Turner
Kurt Hirschhorn
Research01 May 1975
Pediatric Research

Volume: 9, P: 475-480
Directed evolution of a highly efficient TNA polymerase achieved by homologous recombination

The catalytic power of DNA polymerases for artificial genetic polymer (XNA) synthesis remains underdeveloped. Now, the evolution and structure of an α-l-threofuranosyl nucleic acid polymerase is described that achieves XNA synthesis with ∼1 nt s⁻¹ and >99% template-copying fidelity.

Victoria A. Maola
Eric J. Yik
John C. Chaput
Research01 Oct 2024
Nature Catalysis

Volume: 7, P: 1173-1185
Structural basis for TNA synthesis by an engineered TNA polymerase

The laboratory-evolved polymerase Kod-RI catalyzes α-L-threose nucleic acid (TNA) synthesis. Here, the authors present Kod-RI crystal structures that give insights into how TNA triphosphates are selected and extended in a template-dependent manner, which will help to engineer improved TNA polymerases for synthetic genetics applications.

Nicholas Chim
Changhua Shi
John C. Chaput
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-11
Variables Affecting Apolipoprotein B Measurements in 3- to 5-Day-Old Babies: A Study of 4491 Neonates

Barbara L Blades
Nicholas P B Dudman
David E L Wilcken
Research01 Jun 1987
Pediatric Research

Volume: 21, P: 608-614
α-L-Fucosidase in Cultured Skin Fibroblasts from Normal Subjects and Fucosidosis Patients

Nicholas G Beratis
Bryan M Turner
Kurt Hirschhorn
Research01 Jul 1977
Pediatric Research

Volume: 11, P: 862-866
New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

Pharmaceutical compound libraries are an essential part of drug discovery and the screening of libraries for new drug leads is routine. It has now been shown that these heterocycle-rich, diverse libraries can also be used for ligand discovery. The discovery and application of several new ligands to nickel-catalysed cross-electrophile coupling is demonstrated.

Eric C. Hansen
Dylan J. Pedro
Daniel J. Weix
Research08 Aug 2016
Nature Chemistry

Volume: 8, P: 1126-1130
Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

Christopher Dextras
Myagmarjav Dashnyam
Anju Singh
ResearchOpen Access30 Mar 2020
Scientific Reports

Volume: 10, P: 1-11

Search

Use of Aspergillus Niger as a Test Organism for Determining Molybdenum Available in Soils to Crop Plants

Utilization of Nitrate by Micro-organisms

Rapid evolution of a highly efficient RNA polymerase by homologous recombination

Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis

New Analeptics and Hypnotics related to the Barbiturate Antagonist, ‘Bemegride’

Following replicative DNA synthesis by time-resolved X-ray crystallography

Acetylation of Sugars

Cooperative effects in simulated water

Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes

A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA

A novel free-living prochlorophyte abundant in the oceanic euphotic zone

Screening for Familial Hypercholesterolemia in 5000 Neonates: A Recall Study

Shigella sonnei: epidemiology, evolution, pathogenesis, resistance and host interactions

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Arylsulfatase B Deficiency in Maroteaux-Lamy Syndrome: Cellular Studies and Carrier Identification

Directed evolution of a highly efficient TNA polymerase achieved by homologous recombination

Structural basis for TNA synthesis by an engineered TNA polymerase

Variables Affecting Apolipoprotein B Measurements in 3- to 5-Day-Old Babies: A Study of 4491 Neonates

α-L-Fucosidase in Cultured Skin Fibroblasts from Normal Subjects and Fucosidosis Patients

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

Identification of Small Molecule Enhancers of Immunotherapy for Melanoma

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