Nature Search

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Geminin regulates DNA replication by binding CDT1 and preventing MCM helicase loading. Using a reconstituted system and structural modelling, the authors find geminin inhibits via steric clash with MCM, not by blocking the CDT1–MCM interface. Combined with CDK activity, it fully halts licensing.

Joshua Tomkins
Lucy V. Edwardes
Christian Speck
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-23
Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade

Transcriptomic and clinical data analyses from multiple cohorts of patients with cancer receiving immunotherapy find that PD-1 blockade potentiates tumor-specific IgG1 plasma cell responses that complement cellular immunity and contribute to clinical benefit.

Edgar Gonzalez-Kozlova
Robert Sweeney
Sacha Gnjatic
ResearchOpen Access27 Jan 2026
Nature Medicine

P: 1-14
The link between low-stress bicycle facilities and bicycle commuting

Bicycling offers a range of benefits for urban commuters, but the facilities that best facilitate bicycle lane use are still unclear. Using data from 28 US cities, this study found that bicycle lanes and similar low-stress facilities increase ridership markedly.

Nicholas N. Ferenchak
Wesley E. Marshall
ResearchOpen Access02 Jun 2025
Nature Cities

Volume: 2, P: 555-559
Translation suppresses exogenous target RNA-mediated microRNA decay

Stable microRNAs (miRNAs) can undergo turnover via target-directed miRNA degradation (TDMD). Here, the authors show that TDMD triggers in non-coding regions degrade miRNAs more effectively than those in coding regions, where translation interferes with this process.

Tianqi Li
Lu Li
Mingyi Xie
ResearchOpen Access06 Jun 2025
Nature Communications

Volume: 16, P: 1-17
Natural antisense RNA/target RNA interactions: Possible models for antisense oligonucleotide drug design

Nicholas Delihas
Steven E. Rokita
Ping Zheng
Reviews01 Aug 1997
Nature Biotechnology

Volume: 15, P: 751-753
Localization of the human GM-CSF receptor gene to the X–Y pseudoautosomal region

Nicholas M. Gough
David P. Gearing
Grant R. Sutherland
Research21 Jun 1990
Nature

Volume: 345, P: 734-736
A structure-based designed small molecule depletes hRpn13^Pru and a select group of KEN box proteins

Here, the authors identify a small molecule degrader (XL44) for hRpn13 and solve the XL44-hRpn13 structure. XL44 induces apoptosis in myeloma cells with hRpn13 dependency and also targets KEN box proteins PCLAF and RRM2. Loss of hRpn13 and PCLAF abrogates XL44 restriction of cell viability.

Xiuxiu Lu
Monika Chandravanshi
Kylie J. Walters
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-18
The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders

Adeno-associated vectors (AAVs) are frequently used for the delivery of genetic cargo but their small packaging capacity is not suitable for delivery of large constructs, including most CRISPR/dCas9-effector systems. Here the authors report a compact dCas9-based repressor system packaged within a single, optimized AAV vector.

Boris Kantor
Bernadette O’Donovan
Ornit Chiba-Falek
ResearchOpen Access23 Aug 2024
Nature Communications

Volume: 15, P: 1-15
SeqControl: process control for DNA sequencing

SeqControl uses 15 quality metrics of high-throughput sequencing experiments to predict how much sequencing is needed to reach a desired depth of coverage.

Lauren C Chong
Marco A Albuquerque
Paul C Boutros
Research31 Aug 2014
Nature Methods

Volume: 11, P: 1071-1075
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

Bo Liu
Nicholas C. Nicolaides
Bert Vogelstein
Research01 Jan 1995
Nature Genetics

Volume: 9, P: 48-55
Bcr encodes a GTPase-activating protein for p21rac

Dagmar Diekmann
Suzanne Brill
Alan Hall
Research30 May 1991
Nature

Volume: 351, P: 400-402
Rapid evolution of a highly efficient RNA polymerase by homologous recombination

Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. Using DNA shuffling and droplet microfluidics, the current study provides a short evolutionary path from a DNA polymerase to one with robust RNA-synthesizing activity.

Esau L. Medina
Victoria A. Maola
John C. Chaput
Research07 Jan 2026
Nature Chemical Biology

P: 1-9
Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

Nicholas M. Gough
Jill Gough
Ashley R. Dunn
Research28 Jun 1984
Nature

Volume: 309, P: 763-767
Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

Jërg H. Stehle
Nicholas S. Foulkes
Paolo Sassone-Corsi
Research23 Sept 1993
Nature

Volume: 365, P: 314-320
Copper Deficiency of Fruit Trees in Britain

C. BOULD
D. J. D. NICHOLAS
J. M. S. POTTER
Research10 Jun 1950
Nature

Volume: 165, P: 920-921
Directed evolution of a TNA polymerase identifies independent paths to fidelity and catalysis

Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. The current study offers insights into the structural and biochemical changes responsible for improving the fidelity and catalytic activity of a laboratory evolved TNA polymerase.

Mohammad Hajjar
Victoria A. Maola
John C. Chaput
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-14
Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

Neil G. Anderson
James L. Maller
Thomas W. Sturgill
Research15 Feb 1990
Nature

Volume: 343, P: 651-653
Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F

Liang Cao
Barbara Faha
Nicholas Dyson
Research09 Jan 1992
Nature

Volume: 355, P: 176-179
Interaction of cell-type-specific nuclear proteins with immunoglobulin V_H promoter region sequences

Nicholas F. Landolfi
J. Donald Capra
Philip W. Tucker
Research09 Oct 1986
Nature

Volume: 323, P: 548-551
A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

Xavier Estivill
Martin Farrall
Brandon J. Wainwright
Research01 Apr 1987
Nature

Volume: 326, P: 840-845
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Muyang Li
Delin Chen
Wei Gu
Research31 Mar 2002
Nature

Volume: 416, P: 648-653
Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

Nicholas A. Cacalano
David Sanden
James A. Johnston
Research06 Apr 2001
Nature Cell Biology

Volume: 3, P: 460-465
Insecticidal proteins from Bacillus thuringiensis protect corn from corn rootworms

Daniel J. Moellenbeck
Melvin L. Peters
Nicholas Duck
Research01 Jul 2001
Nature Biotechnology

Volume: 19, P: 668-672
Circulation of Salmonella spp. between humans, animals and the environment in animal-owning households in Malawi

In this work, Wilson et al., examined sharing of Salmonella between humans, animals and the environment using household samples from Malawi. They revealed an interconnected web of Salmonella circulation, underscoring the importance of the One Health concept.

Catherine N. Wilson
Patrick Musicha
Nicholas R. Thomson
ResearchOpen Access12 Nov 2025
Nature Communications

Volume: 16, P: 1-14
Functional reconstruction of a eukaryotic-like E1/E2/(RING) E3 ubiquitylation cascade from an uncultured archaeon

In eukaryotic cells, the ubiquitylation system regulates several cellular processes central to protein homoeostasis. Here the authors demonstrate the existence of an eukaryotic-like ubiquitylation cascade requiring E1, E2 and E3-like enzymes in the archaeon C. subterraneum, shedding light on the evolution of the ubiquitin-proteasome system.

Rory Hennell James
Eva F. Caceres
Nicholas P. Robinson
ResearchOpen Access24 Oct 2017
Nature Communications

Volume: 8, P: 1-15
Regulation of E2F transcription by cyclin E–Cdk2 kinase mediated through p300/CBP co-activators

Lorna Morris
K. Elizabeth Allen
Nicholas B. La Thangue
Research10 Mar 2000
Nature Cell Biology

Volume: 2, P: 232-239
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation

Rebecca E. Hussey
Neil E. Richardson
Ellis L. Reinherz
Research07 Jan 1988
Nature

Volume: 331, P: 78-81
Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

Bo Liu
Ramon Parsons
Kenneth W. Kinzler
Research01 Feb 1996
Nature Medicine

Volume: 2, P: 169-174
Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila

David A. Baker
Blandine Mille-Baker
Nicholas J. Dibb
Research01 May 2001
Nature

Volume: 411, P: 330-334
CRISPRoff enables spatio-temporal control of CRISPR editing

Uncontrolled gene editing can lead to off-target effects and chromosomal translocations. Here the authors develop CRISPRoff, light degradable sgRNAs for titratable and spatially defined gene editing.

Jared Carlson-Stevermer
Reed Kelso
Travis Maures
ResearchOpen Access07 Oct 2020
Nature Communications

Volume: 11, P: 1-7
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

Tony Hunter
Nicholas Ling
Jonathan A. Cooper
Research04 Oct 1984
Nature

Volume: 311, P: 480-483
Identification of a human population infected with simian foamy viruses

Walid Heneine
William M. Switzer
Thomas M. Folks
Research01 Apr 1998
Nature Medicine

Volume: 4, P: 403-407
The human PAX6 gene is mutated in two patients with aniridia

Tim Jordan
Isabel Hanson
Veronica van Heyningen
Research01 Aug 1992
Nature Genetics

Volume: 1, P: 328-332
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

Laura A. Laviolette
Julien Mermoud
Othon Iliopoulos
ResearchOpen Access28 Jun 2017
Nature Communications

Volume: 8, P: 1-14
The transcription complex p52–ETS1 is essential for germinal center formation

Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.

Dhakshayini Morgan
Biyan Zhang
Vinay Tergaonkar
Research25 Jul 2025
Nature Immunology

Volume: 26, P: 1553-1566
IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

The role of IFI16 as a DNA sensor is highly controversial. With support from a Nature Communications back-to-back publication from Almineet al. the authors here provide functional evidence that IFI16 is required for DNA sensing via the cGAS-STING pathway in human macrophages.

K. L. Jønsson
A. Laustsen
M. R. Jakobsen
ResearchOpen Access10 Feb 2017
Nature Communications

Volume: 8, P: 1-17
GABA_A-receptor-associated protein links GABA_A receptors and the cytoskeleton

Hongbing Wang
Fiona K. Bedford
Richard W. Olsen
Research07 Jan 1999
Nature

Volume: 397, P: 69-72
Action of brefeldin A blocked by activation of a pertussis-toxin-sensitive G protein

Nicholas T. Ktistakis
Maurine E. Linden
Michael G. Roth
Research26 Mar 1992
Nature

Volume: 356, P: 344-346
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension

TRPV4 dominant mutations cause neuropathy. Here, the authors show that TRPV4 binds and interacts with RhoA, modulating the actin cytoskeleton. Neuropathy-causing mutations of TRPV4 disrupt this complex, leading to RhoA activation and impairment of neurite extension in cultured cells and flies.

Brett A. McCray
Erika Diehl
Charlotte J. Sumner
ResearchOpen Access04 Mar 2021
Nature Communications

Volume: 12, P: 1-17
Motor Nucleus of the Trigeminal Nerve

Nicholas Kostakis
Lydia Ng
Angela Guillozet-Bongaarts
ResearchOpen Access18 Aug 2008
Nature Precedings

P: 1
Proteolytic processing induces a conformational switch required for antibacterial toxin delivery

Contact-dependent growth inhibition (CDI) is an important mechanism of bacterial competition. Here, Bartelli et al. show that proteolytic processing of a CDI toxin induces a conformational switch required for translocation into target bacteria.

Nicholas L. Bartelli
Victor J. Passanisi
Christopher S. Hayes
ResearchOpen Access29 Aug 2022
Nature Communications

Volume: 13, P: 1-17
Pituitary hormone FSH directs the CREM functional switch during spermatogenesis

Nicholas S. Foulkes
Florence Schlotter
Paolo Sassone-Corsi
Research18 Mar 1993
Nature

Volume: 362, P: 264-267
A target for Src in mitosis

Stefano Fumagalli
Nicholas F. Totty
Sara A. Courtneidge
Research28 Apr 1994
Nature

Volume: 368, P: 871-874
Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

Klaus Martin
Didier Trouche
Tony Kouzarides
Research22 Jun 1995
Nature

Volume: 375, P: 691-694
Cell lineage-specific undermethylation of mouse repetitive DNA

Verne Chapman
Lesley Forrester
Janet Rossant
Research19 Jan 1984
Nature

Volume: 307, P: 284-286
Developmental switch of CREM function during spermatogenesis: from antagonist to activator

Nicholas S. Foulkes
Britt Mellström
Paolo Sassone-Corsi
Research02 Jan 1992
Nature

Volume: 355, P: 80-84
Deacetylation of p53 modulates its effect on cell growth and apoptosis

Jianyuan Luo
Fei Su
Wei Gu
Research16 Nov 2000
Nature

Volume: 408, P: 377-381
Multiple myeloma associated long non-coding RNA PLUM confers chemoresistance by enhancing PRC2 mediated UPR pathway activation

Understanding the mechanisms of chemoresistance in multiple myeloma (MM) remains elusive. Here, the authors identify a long non-coding RNA termed as PLUM that is overexpressed in NF-ĸB mutant high-risk MM and interacts with EZH2 to mediate PRC2 complex formation promoting chemoresistance via the activation of the UPR pathway.

Kamalakshi Deka
Jean-Michel Carter
Yinghui Li
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-22
Frequency of Medium-Chain Acyl-CoA Dehydrogenase Deficiency G-985 Mutation in Sudden Infant Death Syndrome

Marvin E Miller
John G Brooks
Richard Insel
Research01 Apr 1992
Pediatric Research

Volume: 31, P: 305-307
Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation

MSL1, a component of the Drosophila dosage compensation complex, genetically and biochemically interacts with CDK7, a subunit of the TFIIH transcription factor, thus revealing a complex interplay between MSL1 and the general transcriptional machinery.

Sarantis Chlamydas
Herbert Holz
Asifa Akhtar
Research16 May 2016
Nature Structural & Molecular Biology

Volume: 23, P: 580-589

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