Nature Search

GTP release-selective agonists prolong opioid analgesic efficacy

Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl without also increasing their respiratory or cardiac effects.

Edward L. Stahl
Matthew A. Swanson
Laura M. Bohn
ResearchOpen Access17 Dec 2025
Nature

P: 1-9
Axillary surgery in patients with sentinel node macrometastases: secondary results of the randomized INSEMA trial

Toralf Reimer
Angrit Stachs
Bernd Gerber
ResearchOpen Access27 Jan 2026
npj Breast Cancer

Volume: 12, P: 1-9
Spatial transcriptomics

By capturing and barcoding RNA in its native tissue location, researchers can visualize and quantify gene expression in situ.

Nicole Rusk
Research Highlights30 Aug 2016
Nature Methods

Volume: 13, P: 710
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin 4 receptor.

Laetitia Coassolo
Niels B. Danneskiold-Samsøe
Katrin J. Svensson
Research05 Mar 2025
Nature

Volume: 641, P: 192-201
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remodeling.

Maria Stahl Madsen
Marjoleine F. Broekema
Eric Kalkhoven
ResearchOpen Access19 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Jennifer Wessel
Audrey Y Chu
Mark O Goodarzi
ResearchOpen Access29 Jan 2015
Nature Communications

Volume: 6, P: 1-16
Don’t put all your epigenetic eggs in one basket

In Caenorhabditis elegans, RNAi-initiated gene silencing can persist for multiple generations. A study shows that this heritable silencing requires parallel contributions of both a nuclear transcriptional silencing pathway and perinuclear condensate-localized poly(UG)-tailed transcripts to produce abundant germline siRNAs in adult progeny.

Nicole M. Bush
Craig P. Hunter
News & Views30 Jun 2022
Nature Cell Biology

Volume: 24, P: 1016-1018
Vertically transferred maternal immune cells promote neonatal immunity against early life infections

Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the risk or severity of infections in newborns.

Ina Annelies Stelzer
Christopher Urbschat
Petra Clara Arck
ResearchOpen Access04 Aug 2021
Nature Communications

Volume: 12, P: 1-14
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

Phenotypic variation and diseases are influenced by factors such as genetic variants and gene expression. Here, Barbeira et al. develop S-PrediXcan to compute PrediXcan results using summary data, and investigate the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes.

Alvaro N. Barbeira
Scott P. Dickinson
Hae Kyung Im
ResearchOpen Access08 May 2018
Nature Communications

Volume: 9, P: 1-20
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Measurements of subclonal expansion of ctDNA in the plasma before surgery may enable the prediction of future metastatic subclones, offering the possibility for early intervention in patients with non-small-cell lung cancer.

Christopher Abbosh
Alexander M. Frankell
Charles Swanton
Research13 Apr 2023
Nature

Volume: 616, P: 553-562
A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

Travis W. Grim
Cullen L. Schmid
Laura M. Bohn
Research23 Aug 2019
Neuropsychopharmacology

Volume: 45, P: 416-425
Nitric oxide induces phosphorylation of p53 and impairs nuclear export

Nicole Schneiderhan
Andreja Budde
Bernhard Brüne
Research15 May 2003
Oncogene

Volume: 22, P: 2857-2868

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