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Waveguide-integrated InAs quantum dots produce quantum-coherent emission in the O-band with promising optical characteristics for scalable quantum networks.

The discovery of a vast reservoir of primordial neutral hydrogen gas surrounding a young galaxy cluster just one billion years after the Big Bang offers new insight into how the first large cosmic structures assembled.

Positrons are key to the production of cold antihydrogen. Here the authors report the sympathetic cooling of positrons by interacting them with laser-cooled Be⁺ ions resulting in a three-fold reduction of the temperature of positrons for antihydrogen synthesis.

This protocol describes a modular method to perform high-throughput electrophysiology on human induced pluripotent stem cell-derived cardiomyocytes, through a combination of simultaneous population patch-clamp and robotic liquid handling.

Entanglement between single photons and solid-state emitters is a key component for photonic quantum computing and networks. Here, using a single electron spin in a quantum dot, the authors present a deterministic photon source achieving three-qubit entanglement of one electron spin and two photons.

Studies on energy-dependent scattering of ultracold atoms were previously carried out near zero collision energies. Here, the authors observe a magnetic Feshbach resonance in ultracold Rb collisions for above-threshold energies and their method can also be used to detect higher partial wave resonances.

The highest-quality JWST spectra reveal that little red dots are young supermassive black holes shrouded in dense cocoons of ionized gas, where electron scattering, not Doppler motions, broadens their spectral lines.

Observations of a fast X-ray transient reveal that it is a gamma-ray-burst explosion from a very distant galaxy that emits light with the wavelength necessary to drive cosmic reionization, the last major phase change in the history of the Universe.

Ferroelectric polymers are key building blocks for flexible electronic devices, but lack functionality and ability to tune their ferroelectric response. Here the authors show a method to introduce functionality in ferroelectric polymers while preserving ferroelectricity and tune the ferroelectric response by incorporating insulating polymer chains.

Fusion-based quantum computing relies on small entangled resource states that are then fused together probabilistically via linear optical circuits. Here, the authors demonstrate temporal fusion—where resource states generated at different times by the same quantum emitter are fused together—using a spin-photon interface in a quantum dot embedded in a photonic crystal waveguide.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Denoising low-counting statistics data in the presence of multiple, unknown noise profiles is a challenging task in scientific applications where high accuracy is required. Oppliger and colleagues train a deep convolutional neural network on pairs of experimental low- and high-noise X-ray diffraction data and demonstrate better performance on experimental noise filtering compared with the case of training on artificial data pairs.

The Arctic is estimated to be a source of atmospheric methane but the sink capacity may be underestimated. This study shows that methane uptake in well-drained Arctic soils is driven by soil moisture and carbon availability, indicating a potential increased methane sink under climate change.

Spectroscopy from the JWST Advanced Deep Extragalactic Survey of a galaxy at redshift 13 shows a singular, bright emission line identified as Lyman-α, suggesting the onset of reionization only 330 Myr after the Big Bang.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

Spin-momentum locking is a fundamental property of condensed matter systems. Here, the authors evidence parallel Weyl spin-momentum locking of multifold fermions in the chiral topological semimetal PtGa.

Bond-cleavage and bond-forming reactions can be performed at local positions on a DNA origami scaffold and imaged at the single-molecule level with atomic force microscopy.

This protocol is used to detect RNA decay intermediates in human cultured cells. Reporter mRNAs can be detected and quantified with molecular biology (northern blot, qPCR) and single-molecule fluorescence microscopy (smFISH, live imaging) approaches.

Kyriakopoulou et al. report that adeno-associated virus-mediated delivery of PKP2 in PKP2^{c.2013delC/WT} induced pluripotent stem cell-derived cardiomyocytes and heterozygous Pkp2^c.1755delA knock-in mice restores cardiomyocyte junctions, enhances cardiac function and mitigates arrhythmogenic substrates leading to arrhythmogenic cardiomyopathy.

Conjugation of DNA to proteins often involves a choice between either expressing recombinant proteins with a specific handle, or labelling wild-type proteins with low site-selectivity. Now preorganization of a DNA–ligand complex to a metal-binding site enables site-selective conjugation of a DNA strand to lysine residues of wild-type proteins and antibodies.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.

An altered automated patch-clamp (APC) approach enables high-throughput recordings from native pig cardiomyocytes and human iPSC-derived cardiomyocytes.

Sea-level rise represents a threat to intertidal oyster reefs and knowledge of their growth rates is needed to quantify the threat. This study presents direct measurements of intertidal oyster reef growth and develops an empirical model of reef accretion. The authors show that previous measurements underestimate growth—the reefs studied here seem able to keep up with projected sea-level rise.

Transient object ASASSN-15lh was previously cast as the most luminous supernova ever discovered. Now, however, there is convincing evidence that its flare was a tidal disruption event: a rapidly-spinning black hole tearing apart a neighbouring star.

In this Review, the authors describe the changes in metabolism that predispose individuals to developing atrial fibrillation (AF) and highlight the potential of available and emerging therapeutic strategies that target metabolic remodelling to treat AF.

An annually resolved ice-core record from West Antarctica indicates that warming driven by local insolation resulting from sea-ice decline began in that region about 2,000 years before warming in East Antarctica, reconciling two alternative explanations for deglacial warming in the Southern Hemisphere.