Nature Search

Rainforest transformation reallocates energy from green to brown food webs

Conversion of rainforest to plantations in Sumatra leads to higher energetic losses in animal food webs aboveground than belowground, with the belowground energy being reallocated from diverse arthropod communities to invasive earthworms.

Anton M. Potapov
Jochen Drescher
Stefan Scheu
ResearchOpen Access14 Feb 2024
Nature

Volume: 627, P: 116-122
Cycling molecular assemblies for Golgi imaging and disruption

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

Weiyi Tan
Qiuxin Zhang
Bing Xu
ResearchOpen Access28 Jan 2026
Nature Communications

Volume: 17, P: 1-20
A host–microbiota interactome reveals extensive transkingdom connectivity

A new technology for proteome-scale assessment of human exoproteome–microbiome interactions exposes an extensive network of transkingdom connectivity.

Nicole D. Sonnert
Connor E. Rosen
Noah W. Palm
Research20 Mar 2024
Nature

Volume: 628, P: 171-179
Within-host evolution of a gut pathobiont facilitates liver translocation

Within-host evolution is a critical regulator of commensal pathogenicity that provides a unique source of stochasticity in the development and progression of microbiota-driven disease.

Yi Yang
Mytien Nguyen
Noah W. Palm
Research13 Jul 2022
Nature

Volume: 607, P: 563-570
Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism

Gut microbiota play a critical role in drug metabolism. Now, by exploring the human gut microbial metabolism of G-protein-coupled receptor (GPCR)-targeting drugs, uncommon pathways and biotransformations are elucidated, revealing how the activity of the metabolized drugs against target GPCRs is modulated.

Qihao Wu
Deguang Song
Jason M. Crawford
Research03 Apr 2025
Nature Chemistry

Volume: 17, P: 808-821
A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase

The DNA polymerase α–primase complex undergoes dramatic configurational rearrangements to synthesize chimeric RNA-DNA primers across two separate active sites while maintaining simultaneous interactions at opposite ends of the primer–template duplex.

Elwood A. Mullins
Lauren E. Salay
Brandt F. Eichman
Research15 Mar 2024
Nature Structural & Molecular Biology

Volume: 31, P: 777-790
Allergic host defences

A review of allergic host defences argues that allergic immunity has an important role in host defence against noxious environmental substances.

Noah W. Palm
Rachel K. Rosenstein
Ruslan Medzhitov
Reviews25 Apr 2012
Nature

Volume: 484, P: 465-472
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions.

Zizhen Yao
Cindy T. J. van Velthoven
Hongkui Zeng
ResearchOpen Access13 Dec 2023
Nature

Volume: 624, P: 317-332
The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

A distinct population of CD4 T cells resides in specific regions of the steady-state brain, and these T cells are programmed in the periphery by the microbiome to coordinate adaptive behaviour.

Tomomi M. Yoshida
Mytien Nguyen
Andrew Wang
Research28 May 2025
Nature

Volume: 643, P: 499-508
Identification of medication–microbiome interactions that affect gut infection

An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can reduce the immune response to pathogens and increase the risk of gastrointestinal infections by altering the composition of the microbiome.

Aman Kumar
Ruizheng Sun
Andrew L. Goodman
Research16 Jul 2025
Nature

Volume: 644, P: 506-515
Not so fast: adaptive suppression of innate immunity

The innate and adaptive immune systems act in concert to effectively combat infection while minimizing collater al damage caused by the host immune response. T cells of the adaptive immune system have now been shown to suppress overzealous early innate responses to infection that can lead to 'cytokine storm'–mediated death (pages 1248–1252).

Noah W Palm
Ruslan Medzhitov
News & Views01 Oct 2007
Nature Medicine

Volume: 13, P: 1142-1144
Genome re-sequencing reveals the history of apple and supports a two-stage model for fruit enlargement

Apple is one of the most important fruit crops. Here, the authors perform deep genome resequencing of 117 diverse accessions and reveal comprehensive models of apple origin, speciation, domestication, and fruit size evolution as well as candidate genes associated with important agronomic traits.

Naibin Duan
Yang Bai
Xuesen Chen
ResearchOpen Access15 Aug 2017
Nature Communications

Volume: 8, P: 1-11
Correction: Corrigendum: T_H2, allergy and group 2 innate lymphoid cells

Paula Licona-Limón
Lark Kyun Kim
Richard A Flavell
Amendments and Corrections18 Dec 2013
Nature Immunology

Volume: 15, P: 109
Adaptive immunity induces mutualism between commensal eukaryotes

Studies of mouse and human IgA responses against Candida albicans and other common fungal species show that host adaptive immunity selects for fungal effectors that promote commensalism and prevent intestinal disease.

Kyla S. Ost
Teresa R. O’Meara
June L. Round
Research14 Jul 2021
Nature

Volume: 596, P: 114-118
A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans

Siddiqi et al. identified lesion locations that reduced probability of PTSD. These were connected to a brain circuit in which increased connectivity was associated with PTSD, thus revealing a PTSD target circuit for therapeutic brain stimulation.

Shan H. Siddiqi
Noah S. Philip
Michael D. Fox
Research24 Sept 2024
Nature Neuroscience

Volume: 27, P: 2231-2239
Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Angel G. Solis
Piotr Bielecki
Richard A. Flavell
Amendments and Corrections12 Nov 2019
Nature

Volume: 575, P: E7
Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca

Differential carbohydrate metabolism elicits distinct pyrazine and pyrazinone autoinducer signalling pathways in Klebsiella oxytoca, which impact bacterial virulence programs.

Randy Hamchand
Kevin Wang
Jason M. Crawford
ResearchOpen Access16 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

PIEZO1 signalling mediates activation of a proinflammatory response to cyclical pressure fluctuations in immune cells.

Angel G. Solis
Piotr Bielecki
Richard A. Flavell
Research21 Aug 2019
Nature

Volume: 573, P: 69-74
Antifungal defense turns 17

Fungal recognition occurs partially through the C-type lectin dectin-1. New studies show that dectin-mediated immune recognition of Candida albicans induces the differentiation of interleukin 17–producing T helper cells that express chemokine receptors characteristic of mucosal homing.

Noah W Palm
Ruslan Medzhitov
News & Views01 Jun 2007
Nature Immunology

Volume: 8, P: 549-551
T_H2, allergy and group 2 innate lymphoid cells

Paula Licona-Limón
Lark Kyun Kim
Richard A Flavell
Reviews20 May 2013
Nature Immunology

Volume: 14, P: 536-542
A meta-analysis of changes in bacterial and archaeal communities with time

Ashley Shade
J Gregory Caporaso
Noah Fierer
ResearchOpen Access11 Apr 2013
The ISME Journal

Volume: 7, P: 1493-1506
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

Ainize Peña-Cearra
Deguang Song
Leticia Abecia
ResearchOpen Access07 Oct 2023
npj Biofilms and Microbiomes

Volume: 9, P: 1-14
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

The inflammasome receptor Nlrp9b defends against enteric viruses by interacting with double-stranded viral RNA-bound helicase Dhx9, triggering gasdermin-D-dependent pyroptotic cell death of infected cells and secretion of Il-18.

Shu Zhu
Siyuan Ding
Richard A. Flavell
Research21 Jun 2017
Nature

Volume: 546, P: 667-670
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Analysis of a mouse model shows that during the course of an immune response, helper T cells undergo functional reprogramming to transdifferentiate into regulatory T cells; this T cell plasticity could possibly be exploited to develop better therapies for restoring immune tolerance in autoimmune diseases.

Nicola Gagliani
Maria Carolina Amezcua Vesely
Richard A. Flavell
Research29 Apr 2015
Nature

Volume: 523, P: 221-225
Reporting guidelines for human microbiome research: the STORMS checklist

The STORMS tool provides guidance for concise and complete reporting of microbiome studies to facilitate manuscript preparation, peer review, reader comprehension of publications, and comparative analysis of published results.

Chloe Mirzayi
Audrey Renson
Levi Waldron
Reviews17 Nov 2021
Nature Medicine

Volume: 27, P: 1885-1892
IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

Jason R. Catanzaro
Juliet D. Strauss
Noah W. Palm
ResearchOpen Access19 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota

James J Goedert
Xing Hua
Heather Spencer Feigelson
ResearchOpen Access23 Jan 2018
British Journal of Cancer

Volume: 118, P: 471-479

Search

Rainforest transformation reallocates energy from green to brown food webs

Cycling molecular assemblies for Golgi imaging and disruption

A host–microbiota interactome reveals extensive transkingdom connectivity

Within-host evolution of a gut pathobiont facilitates liver translocation

Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism

A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase

Allergic host defences

A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain

The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour

Identification of medication–microbiome interactions that affect gut infection

Not so fast: adaptive suppression of innate immunity

Genome re-sequencing reveals the history of apple and supports a two-stage model for fruit enlargement

Correction: Corrigendum: T_H2, allergy and group 2 innate lymphoid cells

Adaptive immunity induces mutualism between commensal eukaryotes

A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans

Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Antifungal defense turns 17

T_H2, allergy and group 2 innate lymphoid cells

A meta-analysis of changes in bacterial and archaeal communities with time

Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Reporting guidelines for human microbiome research: the STORMS checklist

IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota

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