Nature Search

Microproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila

Drosophila Microproteins Simba1/2 act in neural stem cells and blood-brain-barrier glia to promote reactivation of neural stem cells via activating WNT/Wingless signaling, while human ortholog ZNF706 is found to have a conserved role in activating WNT pathway.

Jiaen Lin
Qiannan Deng
Hongyan Wang
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Components of wingless signalling in Drosophila

Esther Siegfried
Elizabeth L. Wilder
Norbert Perrimon
Research06 Jan 1994
Nature

Volume: 367, P: 76-80
dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

Jasprien Noordermeer
John Klingensmith
Roel Nusse
Research06 Jan 1994
Nature

Volume: 367, P: 80-83
Tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms

What initiates the wasting syndrome Cancer Cachexia is unclear. Here, the authors show that fly gut-tumours reduce neuronally driven protein-food choices before organ wasting. This prevents the fly from meeting its protein needs, initiating organ wasting symptoms and raising the risk of death.

Afroditi Petsakou
Elizabeth Filine
Norbert Perrimon
ResearchOpen Access06 Mar 2026
Nature Communications

P: 1-15
Requirement of the Drosophila raf homologue for torso function

Linda Ambrosio
Anthony P. Mahowald
Norbert Perrimon
Research16 Nov 1989
Nature

Volume: 342, P: 288-291
wingless refines its own expression domain on the Drosophila wing margin

Eric J. Rulifson
Craig A. Micchelli
Seth S. Blair
Research07 Nov 1996
Nature

Volume: 384, P: 72-74
The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development

Robert Finklstein
Norbert Perrimon
Research02 Aug 1990
Nature

Volume: 346, P: 485-488
The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz

Yan Yu
Willis Li
Leslie Pick
Research06 Feb 1997
Nature

Volume: 385, P: 552-555
Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3

Esther Siegfried
Lizabeth A. Perkins
Norbert Perrimon
Research28 Jun 1990
Nature

Volume: 345, P: 825-829
Erratum: wingless refines its own expression domain on the Drosophila wing margin

Eric J. Rulifson
Craig A. Micchelli
Seth S. Blair
Amendments and Corrections12 Dec 1996
Nature

Volume: 384, P: 597
The roles of the Drosophila JAK/STAT pathway

Martin P Zeidler
Erika A Bach
Norbert Perrimon
Research25 May 2000
Oncogene

Volume: 19, P: 2598-2606
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels

This study develops tissue-specific genome-scale metabolic models for Drosophila and shows how constraint-based flux analyses from the muscle model can identify high sugar diet-induced metabolic dysregulation at reaction and pathway levels.

Sun Jin Moon
Yanhui Hu
Norbert Perrimon
ResearchOpen Access19 Jan 2026
Nature Communications

Volume: 17, P: 1-20
Drosophila and the genetics of the internal milieu

Pierre Leopold
Norbert Perrimon
Reviews08 Nov 2007
Nature

Volume: 450, P: 186-188
A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes

Mosquitoes are major vectors for the transmission of many serious pathogens. This study uses genome-wide CRISPR screens in the mosquito, Anopheles gambiae, to reveal new insights into mosquito fitness and the function of clodronate-liposome mediated immune cell ablation.

Enzo Mameli
George-Rafael Samantsidis
Ryan C. Smith
ResearchOpen Access24 Nov 2025
Nature Communications

Volume: 16, P: 1-15
The Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth

This study demonstrates that the Drosophila proventriculus, the structure at the anterior of gut that synthesizes the peritrophic membrane, lacks stem cells but undergoes continual endocycling to compensate for cells loss during aging or damage.

Ben Ewen-Campen
Weihang Chen
Norbert Perrimon
ResearchOpen Access27 Jan 2026
Nature Communications

Volume: 17, P: 1-19
Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

The fruit fly Drosophila melanogaster has emerged as a model to characterize the mechanisms of tumor-induced host organ dysfunction. Here, Xu, Liu et al. describe a mechanism of tumor-induced kidney dysfunction through hyper-activation of the PvR/JNK/Jra pathway in the Principal cells of the fly kidney/Malpighian tubules.

Jun Xu
Ying Liu
Norbert Perrimon
ResearchOpen Access09 Feb 2024
Nature Communications

Volume: 15, P: 1-14
CRISPR screens in Drosophila cells identify Vsg as a Tc toxin receptor

A genome-wide CRISPR–Cas9-mediated knockout screen in Drosophila cells identifies Visgun as a proteinaceous receptor for toxin complex toxins, demonstrating the utility of this approach for investigating insecticidal toxins and pathogens.

Ying Xu
Raghuvir Viswanatha
Min Dong
Research28 Sept 2022
Nature

Volume: 610, P: 349-355
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway

Unmet expectations, a previously uncharacterized fly protein, is a SAM sensor for the mTORC1 pathway. Tracing the evolution of Unmet reveals that the pathway uses the GATOR2 complex to capture and repurpose ancestral enzymes as nutrient sensors.

Grace Y. Liu
Patrick Jouandin
David M. Sabatini
ResearchOpen Access21 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Next-generation large-scale binary protein interaction network for Drosophila melanogaster

Maps of protein-protein interactions (PPIs) help identify new components of pathways, complexes, and processes. In this work, state-of-the-art methods are used to identify binary Drosophila PPIs, generating broadly useful physical and data resources.

Hong-Wen Tang
Kerstin Spirohn
Stephanie E. Mohr
ResearchOpen Access15 Apr 2023
Nature Communications

Volume: 14, P: 1-16
Activation of posterior gap gene expression in the Drosophila blastoderm

Rolando Rivera-Pomar
Xiangyi Lu
Herbert Jäckle
Research20 Jul 1995
Nature

Volume: 376, P: 253-256
Efficient proximity labeling in living cells and organisms with TurboID

Protein–protein interactions in cells are rapidly identified with improved proximity labeling methods.

Tess C Branon
Justin A Bosch
Alice Y Ting
Research20 Aug 2018
Nature Biotechnology

Volume: 36, P: 880-887
A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs

Transgenic RNA ‘sponges’ that inhibit specific microRNAs are valuable tools for functional studies. Fulga et al. present a library of conditional microRNA sponges in Drosophila, and reveal widespread involvement of microRNAs in the maintenance of adult muscle structure and function.

Tudor A. Fulga
Elizabeth M. McNeill
David Van Vactor
ResearchOpen Access17 Jun 2015
Nature Communications

Volume: 6, P: 1-10
Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila

Drosophila oenocytes accumulate fat during periods of starvation similar to the liver. This study shows that oenocytes regulate fat metabolism during starvation via Desat1-dependent secretion of ImpL2, linking lipid desaturation to lipoprotein trafficking, insulin signaling and fat body triacylglycerol storage for survival.

Jiayi Li
Kerui Huang
Matias Simons
ResearchOpen Access21 Nov 2025
Nature Communications

Volume: 16, P: 1-16
Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

Forward genetic approaches such as CRISPR screens are powerful ways to identify essential genes and those that influence host-pathogen interactions. Here the authors design a bioinformatics portal for sgRNA design and a recombination-mediated cassette system for delivery into mosquito cell lines.

Raghuvir Viswanatha
Enzo Mameli
Norbert Perrimon
ResearchOpen Access24 Nov 2021
Nature Communications

Volume: 12, P: 1-13
Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila

How the Drosophila lymph gland hemocytes develop and are regulated at a single-cell level is unclear. Here, the authors use single-cell RNA sequencing to show heterogeneity of developing hemocytes in the lymph gland and how they react to wasp infestation, and compare hemocytes from two independent origins.

Bumsik Cho
Sang-Ho Yoon
Jiwon Shim
ResearchOpen Access08 Sept 2020
Nature Communications

Volume: 11, P: 1-18
A phosphate-sensing organelle regulates phosphate and tissue homeostasis

PXo bodies, non-canonical multilamellar organelles, serve as a reservoir for intracellular inorganic phosphate and are a critical regulator of both cytosolic phosphate levels and tissue homeostasis.

Chiwei Xu
Jun Xu
Norbert Perrimon
Research03 May 2023
Nature

Volume: 617, P: 798-806
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Xin Gu
Patrick Jouandin
David M. Sabatini
Amendments and Corrections13 Sept 2022
Nature

Volume: 609, P: E11
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice

In Drosophila and mouse models of cancer cachexia, Liu et al. show that tumour-derived cytokines induce hepatic gluconeogenesis, which in turn leads to dysregulation of metabolism and drives cancer cachexia.

Ying Liu
Ezequiel Dantas
Norbert Perrimon
ResearchOpen Access16 Apr 2025
Nature Metabolism

Volume: 7, P: 823-841
Proteomics of protein trafficking by in vivo tissue-specific labeling

The network of proteins secreted for interorgan communication is poorly understood. Here, the authors develop a method, based on protein labeling, to study cell-specific secretomes and interorgan protein trafficking, and demonstrate their approach in Drosophila and mouse models.

Ilia A. Droujinine
Amanda S. Meyer
Norbert Perrimon
ResearchOpen Access22 Apr 2021
Nature Communications

Volume: 12, P: 1-22
Optimized CRISPR tools and site-directed transgenesis towards gene drive development in Culex quinquefasciatus mosquitoes

Culex mosquitoes are a global vector for insect-borne diseases, though progress with genetic tools lags behind other mosquito species. Here the authors present a Cas9-based toolkit and methods that could support future gene drive development in these mosquitoes.

Xuechun Feng
Víctor López Del Amo
Valentino M. Gantz
ResearchOpen Access20 May 2021
Nature Communications

Volume: 12, P: 1-13
Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC)

Genome-wide CRISPR screens map how genes support survival and contribute to diverse biological functions. Here, the authors use antiCRISPR to enhance genome-wide CRISPR screening in Drosophila and generate higher-resolution maps of cell fitness, toxin, and drug-resistance.

Raghuvir Viswanatha
Samuel Entwisle
Norbert Perrimon
ResearchOpen Access15 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

Stem cells of the Drosophila midgut sense mechanical signals in vivo through the stretch-activated ion channel Piezo, which is expressed on previously unidentified enteroendocrine precursor cells.

Li He
Guangwei Si
Norbert Perrimon
Research07 Feb 2018
Nature

Volume: 555, P: 103-106
Integrated activity of PDZ protein complexes regulates epithelial polarity

David Bilder
Markus Schober
Norbert Perrimon
Research16 Dec 2002
Nature Cell Biology

Volume: 5, P: 53-58
Author Correction: Bioinformatic and cell-based tools for pooled CRISPR knockout screening in mosquitos

Raghuvir Viswanatha
Enzo Mameli
Norbert Perrimon
Amendments and CorrectionsOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1
Erratum: Integrating protein-protein interaction networks with phenotypes reveals signs of interactions

Arunachalam Vinayagam
Jonathan Zirin
Norbert Perrimon
Amendments and Corrections27 Jun 2014
Nature Methods

Volume: 11, P: 773
Building on the shoulders of giants

Norbert Perrimon
Research Highlights01 Jul 2009
Nature Reviews Molecular Cell Biology

Volume: 10, P: 444
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

Yohanns Bellaiche
Inge The
Norbert Perrimon
Research01 Jul 1998
Nature

Volume: 394, P: 85-88
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster

Jian-Quan Ni
Michele Markstein
Norbert Perrimon
Research16 Dec 2007
Nature Methods

Volume: 5, P: 49-51
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling

Adam Friedman
Norbert Perrimon
Research01 Nov 2006
Nature

Volume: 444, P: 230-234
Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila

Intercellular calcium waves (ICWs) coordinate multicellular responses, although precise mechanisms are less understood. Here, authors show that nutrient-triggered hormone release from the brain stimulates gap-junction-independent ICWs in Drosophila adipose tissue.

Muhammad Ahmad
Shang Wu
Li He
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Heparan sulphate proteoglycans: the sweet side of development

Udo Häcker
Kent Nybakken
Norbert Perrimon
Reviews01 Jul 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 530-541
Our fly cousins' gut

What do we humans have in common with flies? Quite a lot, at least at the cellular and molecular levels. Our intestine, for instance, is similar to that of the fly, not only in function but also in its development and maintenance.

Chrysoula Pitsouli
Norbert Perrimon
News & Views30 Jul 2008
Nature

Volume: 454, P: 592-593
Do-it-yourself RNAi made easy?

Enzymatically generated small interfering RNAs are a welcome addition in the tool box of scientists performing large-scale RNAi screens.

Bernard Mathey-Prevot
Norbert Perrimon
News & Views01 Apr 2007
Nature Methods

Volume: 4, P: 308-309
Author Correction: Efficient proximity labeling in living cells and organisms with TurboID

Tess C. Branon
Justin A. Bosch
Alice Y. Ting
Amendments and Corrections20 Nov 2019
Nature Biotechnology

Volume: 38, P: 108
Response to “Problems with LAP nomenclature”

David Bilder
Daniel Birnbaum
Norbert Perrimon
Correspondence01 Apr 2001
Nature Cell Biology

Volume: 3, P: E90
Journal club

Norbert Perrimon
Research Highlights09 Apr 2008
Nature

Volume: 452, P: 669
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

Kent Nybakken
Steven A Vokes
Norbert Perrimon
Research20 Nov 2005
Nature Genetics

Volume: 37, P: 1323-1332
Cholinergic neurons trigger epithelial Ca²⁺ currents to heal the gut

A subpopulation of cholinergic neurons triggers Ca²⁺ currents among enterocytes to promote return to homeostasis after injury, and disruption of this process leads to gut inflammation and hyperplasia in Drosophila.

Afroditi Petsakou
Yifang Liu
Norbert Perrimon
Research18 Sept 2023
Nature

Volume: 623, P: 122-131
REPTOR and CREBRF encode key regulators of muscle energy metabolism

Obesity and cancer-induced cachexia are linked to an impairment in the ability of muscle to use glucose or lipids interchangeably as energy substrates. Here, the authors propose that Drosophila REPTOR and its mammalian ortholog CREBRF act as key transcriptional regulators of fuel choice in muscle.

Pedro Saavedra
Phillip A. Dumesic
Norbert Perrimon
ResearchOpen Access15 Aug 2023
Nature Communications

Volume: 14, P: 1-20
Functional genomics reveals genes involved in protein secretion and Golgi organization

Frederic Bard
Laetitia Casano
Vivek Malhotra
Research02 Feb 2006
Nature

Volume: 439, P: 604-607

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