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Showing 1–5 of 5 results
Advanced filters: Author: Olesya Plazyo Clear advanced filters

  • High spatial resolution is essential for resolving cellular and subcellular organization in tissues. Here, authors present Seq-Scope-X, which integrates tissue expansion with Seq-Scope to achieve an order-of-magnitude improvement in resolution of spatial transcriptomics and proteomics.

    • Angelo Anacleto
    • Weiqiu Cheng
    • Jun Hee Lee
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-20

  • Generalised pustular psoriasis (GPP) is a severe type of psoriasis characterized by epidermal neutrophil infiltration and potentially life-threatening flares. Here the authors use single cell and spatial transcriptomic analysis of skin samples implicating contact between IL36G+ keratinocytes and neutrophils as well as ligand-receptor interactions of fibroblasts with T cells, neutrophils or macrophages.

    • Rundong Jiang
    • Joseph Kirma
    • Johann E. Gudjonsson
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-16

  • Systemic sclerosis (SSc) is an autoimmune disease causing skin fibrosis and organ inflammation. Here the authors generate and analyze SSc skin single cell RNA sequencing data to propose contributions from both myofibroblasts and endothelial-to-mesenchymal -transitioning cells (EndoMT) to skin fibrosis, and to implicate the involvement of Hippo signaling pathways.

    • Feiyang Ma
    • Pei-Suen Tsou
    • Johann E. Gudjonsson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Changes in Psoriasis and other inflammatory skin diseases during severity stages can be investigated using single cell and spatial transcriptomics. Here the authors compare different inflammatory skin diseases to emphasise differences in immune cells and inflammatory markers particularly keratinocytes and fibroblasts.

    • Feiyang Ma
    • Olesya Plazyo
    • Johann E. Gudjonsson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Modlin and colleagues examined the skin lesions of human leprosy patients using single-cell RNA sequencing coupled to cellular spatial mapping. Their analysis maps the architecture of granulomas in leprosy lesions from patients with leprosy with localized disease (tuberculoid leprosy, reversal reaction) to those with progressive infection (lepromatous leprosy).

    • Feiyang Ma
    • Travis K. Hughes
    • Robert L. Modlin
    Research
    Nature Immunology
    Volume: 22, P: 839-850