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A lipidomics roadmap: from basic research to societal challenges

Lipidomics, a rapidly evolving field at the interface of biology and analytical chemistry, enables comprehensive analysis of lipids in biological systems. This Perspective outlines advances, challenges, and future directions, highlighting applications of lipidomics in basic and translational science.

Maria Fedorova
Anne K. Bendt
Maria Rosário Domingues
ReviewsOpen Access28 May 2026
Nature Communications

Volume: 17, P: 1-15
Small molecules that target group II introns are potent antifungal agents

High-throughput screening followed by an examination of structure–activity relationship-based optimization resulted in the identification of potent small-molecule inhibitors of group IIB intron splicing in fungal organisms.

Olga Fedorova
G. Erik Jagdmann Jr.
Anna Marie Pyle
Research15 Oct 2018
Nature Chemical Biology

Volume: 14, P: 1073-1078
Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

Mazan-Mamczarz, Tsitsipatis and colleagues apply single-cell and spatial transcriptomics to mouse models of atherosclerosis to map senescent cells contributing to plaque instability and arterial remodeling. They define a transcriptomic signature of vascular senescence.

Krystyna Mazan-Mamczarz
Dimitrios Tsitsipatis
Allison B. Herman
Research14 Jul 2025
Nature Aging

Volume: 5, P: 1528-1547
Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry

Pavel Flegontov
Piya Changmai
Tatiana V. Tatarinova
ResearchOpen Access11 Feb 2016
Scientific Reports

Volume: 6, P: 1-12
Lipidome atlas of the adult human brain

While our brain is primarily composed of lipids, their functions have largely remained unexplored. Here, authors show that specific lipids can be linked to the structural organization and functional hierarchy of the human and macaque brain.

Maria Osetrova
Anna Tkachev
Philipp Khaitovich
ResearchOpen Access25 May 2024
Nature Communications

Volume: 15, P: 1-18
Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique

Tatyana V Nasedkina
Olga E Fedorova
Alexander S Zasedatelev
Research17 May 2006
European Journal of Human Genetics

Volume: 14, P: 991-998
Dimeric magnetic dumbbell nanoparticles with selective immobilization of chromophores for improved tumor theranostics

Iuliia Chudosai
Petr Ostroverkhov
Maxim Abakumov
ResearchOpen Access05 Mar 2026
Scientific Reports

Volume: 16, P: 1-12
Cancer-testis antigens, semenogelins 1 and 2, exhibit different anti-proliferative effects on human lung adenocarcinoma cells

Oleg Shuvalov
Alyona Kizenko
Nickolai Barlev
ResearchOpen Access22 Oct 2020
Cell Death Discovery

Volume: 6, P: 1-8
Ancient human genomes suggest three ancestral populations for present-day Europeans

A sequencing study comparing ancient and contemporary genomes reveals that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, ancient north Eurasians (related to Upper Palaeolithic Siberians) and early European farmers of mainly Near Eastern origin.

Iosif Lazaridis
Nick Patterson
Johannes Krause
Research17 Sept 2014
Nature

Volume: 513, P: 409-413
The 2′-OH group at the group II intron terminus acts as a proton shuttle

Group II introns can act as mobile genomic elements and integrate into genomic DNA through reverse splicing. A selective nucleotide modification approach was used to show that the 2′-hydroxyl at the ribozyme 3′ terminus plays a catalytic role as a proton shuttle during reverse splicing.

Michael Roitzsch
Olga Fedorova
Anna Marie Pyle
Research31 Jan 2010
Nature Chemical Biology

Volume: 6, P: 218-224
Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study

Michél Strauss
Wayne Smith
Aletta E. Schutte
Research15 Jan 2018
Hypertension Research

Volume: 41, P: 183-192
Genomic analyses inform on migration events during the peopling of Eurasia

Whole-genome sequencing of individuals from 125 populations provides insight into patterns of genetic diversity, natural selection and human demographic history during the peopling of Eurasia and finds evidence for genetic vestiges of an early expansion of modern humans out of Africa in Papuans.

Luca Pagani
Daniel John Lawson
Mait Metspalu
Research21 Sept 2016
Nature

Volume: 538, P: 238-242
Author Correction: Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles

Manar M. Obiedallah
Maxim A. Mironov
Gennady L. Rusinov
Amendments and CorrectionsOpen Access25 Jan 2024
Scientific Reports

Volume: 14, P: 1
Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles

Manar M. Obiedallah
Maxim A. Mironov
Gennady L. Rusinov
ResearchOpen Access04 Jan 2024
Scientific Reports

Volume: 14, P: 1-14
High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect

Tuyara V. Borisova
Aleksandra M. Cherdonova
Nikolay A. Barashkov
ResearchOpen Access03 Jul 2024
Scientific Reports

Volume: 14, P: 1-10
The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase

Alexandra Daks
Alexey Petukhov
Nickolai Barlev
ResearchOpen Access05 Jun 2021
Cell Death & Disease

Volume: 12, P: 1-14
SEMG1/2 augment energy metabolism of tumor cells

Oleg Shuvalov
Alyona Kizenko
Nikolai Barlev
ResearchOpen Access11 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-14
Second malignant neoplasms after treatment of non-Hodgkin’s lymphoma—a retrospective multinational study of 189 children and adolescents

Andishe Attarbaschi
Elisa Carraro
Marta Pillon
Research11 May 2020
Leukemia

Volume: 35, P: 534-549
Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis

Olga Fedorova
Alexey Petukhov
Nikolai A. Barlev
Research19 Nov 2018
Oncogene

Volume: 38, P: 2108-2122
Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation

Alexander Lopachev
Anna Volnova
Raul Gainetdinov
ResearchOpen Access30 Oct 2019
Scientific Reports

Volume: 9, P: 1-13
The genetic legacy of legendary and historical Siberian chieftains

Analysis of human remains from 15th-19th Century North-Eastern Siberia, in combination with modern samples, indicate the drivers of present day Yakut genetic diversity, and enable archaeological interpretations of population dynamics at this time.

Vincent Zvénigorosky
Sylvie Duchesne
Christine Keyser
ResearchOpen Access16 Oct 2020
Communications Biology

Volume: 3, P: 1-9
Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene

Nikolay A. Barashkov
Fedor A. Konovalov
Sardana A. Fedorova
Research25 Mar 2021
European Journal of Human Genetics

Volume: 29, P: 965-976
Autosomal recessive deafness 1A (DFNB1A) in Yakut population isolate in Eastern Siberia: extensive accumulation of the splice site mutation IVS1+1G>A in GJB2 gene as a result of founder effect

Nikolay A Barashkov
Lilya U Dzhemileva
Elza K Khusnutdinova
Research21 Jul 2011
Journal of Human Genetics

Volume: 56, P: 631-639
Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer

Sergey Parfenyev
Aastha Singh
Niсkolai A. Barlev
ReviewsOpen Access04 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-16
Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells

Oleg Shuvalov
Alyona Kizenko
Nikolai Barlev
ReviewsOpen Access08 May 2021
Cell Death Discovery

Volume: 7, P: 1-9
Attenuation of p53 mutant as an approach for treatment Her2-positive cancer

Olga Fedorova
Alexandra Daks
Nikolai Barlev
ReviewsOpen Access10 Oct 2020
Cell Death Discovery

Volume: 6, P: 1-8

Search

A lipidomics roadmap: from basic research to societal challenges

Small molecules that target group II introns are potent antifungal agents

Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry

Lipidome atlas of the adult human brain

Rapid genotyping of common deficient thiopurine S-methyltransferase alleles using the DNA-microchip technique

Dimeric magnetic dumbbell nanoparticles with selective immobilization of chromophores for improved tumor theranostics

Cancer-testis antigens, semenogelins 1 and 2, exhibit different anti-proliferative effects on human lung adenocarcinoma cells

Ancient human genomes suggest three ancestral populations for present-day Europeans

The 2′-OH group at the group II intron terminus acts as a proton shuttle

Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT Study

Genomic analyses inform on migration events during the peopling of Eurasia

Author Correction: Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles

Optimization, characterization, and cytotoxicity studies of novel anti-tubercular agent-loaded liposomal vesicles

High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase

SEMG1/2 augment energy metabolism of tumor cells

Second malignant neoplasms after treatment of non-Hodgkin’s lymphoma—a retrospective multinational study of 189 children and adolescents

Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis

Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation

The genetic legacy of legendary and historical Siberian chieftains

Autosomal recessive cataract (CTRCT18) in the Yakut population isolate of Eastern Siberia: a novel founder variant in the FYCO1 gene

Autosomal recessive deafness 1A (DFNB1A) in Yakut population isolate in Eastern Siberia: extensive accumulation of the splice site mutation IVS1+1G>A in GJB2 gene as a result of founder effect

Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer

Emerging roles of cancer-testis antigenes, semenogelin 1 and 2, in neoplastic cells

Attenuation of p53 mutant as an approach for treatment Her2-positive cancer

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