Molecular 'snapshots' of the MnmA thiouridylase–tRNA complex reveal that during RNA sulphuration, a key α-helix forms around the active site, burying U34 into the catalytic pocket. This 'closed' conformation of the active site ensures that sulphur is incorporated into uridine at the correct place.
- Tomoyuki Numata
- Yoshiho Ikeuchi
- Osamu Nureki
