Sensitization leads to hyperalgesia and depends on mechanisms similar to those involved in memory formation. Here, Bonin and De Koninck find that hyperalgesia can be reversed by combining reactivation of peripheral afferents with spinal administration of a protein synthesis inhibitor, thereby identifying a spinal analogue of memory re-consolidation that enables erasing pain hypersensitivity.
- Robert P Bonin
- Yves De Koninck
