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The percolation transition has been regarded as model-independent, namely determined by the geometry of a system but otherwise identical for bond or site percolation models. Here, the authors show the violation of this assumption both analytically and numerically for networks with null percolation thresholds.

An improved reference genome of sweet orange and newly sequenced genomes of its somatic mutants uncover the global pattern of somatic variations, the diversification and dispersal history of sweet orange and candidate genes controlling fruit taste and flavour.

Experiments at the Joint European Torus tokamak show improved thermal ion confinement in the presence of highly energetic ions and Alfvénic instabilities in the plasma.

Here, the authors have performed a multi-population GWAS meta-analysis of pediatric steroid sensitive nephrotic syndrome cases to discover 12 loci (4 novel), fine-map HLA, implicate kidney and immune factors, and associate the polygenic risk score with earlier disease onset.

The frequency scaling exponent of low-frequency vibrational excitations in glasses remains controversial in the literature. Here, Schirmacher et al. show that the exponent depends on the statistics of the small values of the local stresses, which is governed by the detail of interaction potential.

Clinical and genetic evaluation of individuals with childhood-onset amyotrophic lateral sclerosis identifies a new monogenic cause for early-onset ALS and proposes a specific metabolic mechanism leading to motor neuron disease via sphingolipid excess.

Triggering and sustaining fusion reactions — with the goal of overall energy production — in a tokamak plasma requires efficient heating. Radio-frequency heating of a three-ion plasma is now experimentally shown to be a potentially viable technique.

Single-molecule magnets (SMMs) are multinuclear clusters whose behaviour typically relies on intramolecular spin-coupling interactions between neighbouring metal ions. A diuranium–arene complex has now been prepared that shows behaviour characteristic of an SMM without relying on this type of superexchange mechanism. This may enable the construction of SMMs that maintain their magnetism at higher temperatures.

Nuclei with equal neutron (N) and proton (Z) numbers show enhanced correlations that have been predicted to favour an unusual type of pairing, distinct from normal nuclear superfluidity. Here, technically challenging observations are reported of excited states in the N = Z = 46 nucleus ⁹²Pd, from which evidence is inferred for a type of spin-aligned structure in the ground and low-lying excited states, not established in nuclei before and differing from previous predictions.

SECOMBIT was a clinical trial testing different sequences of immunotherapy (ipilimumab plus nivolumab) and targeted therapy (encorafenib plus binimetinib) for untreated BRAF-mutated metastatic melanoma. Here the authors report 4-year survival outcomes, confirming long-term benefit with first-line immunotherapy, and preliminary biomarkers evaluation.

The authors use TetTag pharmacogenetics to mark neuronal ensembles activated in the preoptic hypothalamus during dexmedeotomidine-induced sedation or recovery sleep. When these ensembles were selectively reactivated, NREM sleep and the accompanying drop in body temperature were recapitulated. Thus α₂ adrenergic receptor–induced sedation and recovery sleep share circuitry sufficient for producing these states.

Future tokamak nuclear fusion reactors depend on efficient current drive methods, but it is hard to penetrate the high-density plasma in these devices. In this paper the authors show that radio frequency waves coupled to lower hybrid plasma waves, when the peripheral temperature of the plasma is high, can penetrate the plasma core.

Genome sequencing and phylogenomic analysis show that the lungfish, not the coelacanth, is the closest living relative of tetrapods, that coelacanth protein-coding genes are more slowly evolving than those of tetrapods and lungfish, and that the genes and regulatory elements that underwent changes during the vertebrate transition to land reflect adaptation to a new environment.

Super-massive black holes in active galaxies can accelerate particles to relativistic energies, producing jets with associated γ-ray emission. Galactic 'microquasars' also produce relativistic jets; however, apart from an isolated event detected in Cygnus X-1, there has hitherto been no systematic evidence for the acceleration of particles to gigaelectronvolt or higher energies in a microquasar. Here, a report of four γ-ray flares with energies above 100 MeV from the microquasar Cygnus X-3 illuminates this important problem.

Here we report the sequence of 569,202 base pairs of Saccharomyces cerevisiae chromosome V. Analysis of the sequence revealed a centromere, two telomeres and 271 open reading frames (ORFs) plus 13 tRNAs and four small nuclear RNAs. There are two Ty1 transposable elements, each of which contains an ORF (included in the count of 271). Of the ORFs, 78 (29%) are new, 81 (30%) have potential homologues in the public databases, and 112 (41%) are previously characterized yeast genes.

Drosophila telomeres are elongated by transposition of specialized retroelements rather than telomerase activity. Here, the authors show that Separase is enriched at Drosophila telomeres and loss of Sse, the gene encoding Separase, leads to telomere defects, suggesting a role for Separase in telomere protection.

Theory and experiment show that quantum correlations violate the instrumental test—a common statistical method used to estimate the strength of causal relationships between two variables.

Rare quantum tunneling two-level systems are known to govern the glass physics at low temperatures, but it remains challenging to detect them in simulations. Ciarella et al. show a machine learning approach to efficiently identify the structural defects, allowing to predict the quantum splitting.

Delafossite PdCoO₂ boasts outstanding electronic transport properties, making it an interesting plasmonic material. Here, experimental evidence of surface plasmons in micro-ribbon samples is presented.

The electron dynamics of single-layer Bi₂Sr_2−xLa_xCuO_6+δ is studied as a function of doping, revealing the evolution of charge-transfer excitations from incoherent and localized (as in a Mott insulator) to coherent and delocalized (as in a conventional metal).

The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that influence common brain disorders.

Alien species of animals and plants can invade new regions of the earth. This study performs a global analysis of temporal dynamics and spatial patterns of alien species introductions over the past 200 years, and reports no saturation in the rate at which these invasion are increasing.

TDP43 aggregates are a hallmark of amyotrophic lateral sclerosis. By using deep mutagenesis to measure the toxicity of more than 50,000 mutations in the prion domain of TDP43, the authors conclude that mutations that increase toxicity promote formation of liquid-like condensates, while aggregation of TDP43 is protective for the cell.

The complete maximisation of the entanglement between two complementary blocks of spins due to the dynamics of spin chains remains to be observed. Here, Pitsios et al. simulate such dynamics by propagating single photons in an integrated photonic circuit.

Numerical evidence now supports the idea that a liquid–liquid transition forms a generic feature of tetrahedrally coordinated liquids. This result establishes the physical validity of such a transition and provides a possible explanation for the anomalous behaviour of liquid water.

Petrological studies along with volcano monitoring data relate the unusual 2019 explosive activity at Stromboli volcano (Italy) to deep magma recharges up to a few days prior the eruption and a direct link between deep and shallow magma reservoirs.

Protein corona formation is known to have significant effects upon nanomaterials application. Here, the authors investigate the creation of a protein coating on liposomes with the aim of improving liposome circulation time by avoiding leukocyte capture and demonstrated application in vitro and ex vivo.

The nature of the doping dependent superconducting transition remains elusive for a two dimensional electron gas at the LaAlO₃/SrTiO₃ interface. Here, Singh et al. report superfluid stiffness and the superconducting gap energy at such interface as a function of carrier density.

New types of nonlocal correlations can arise in quantum networks, but experiments have not been done for more than two independent sources. Here, the authors violate a chained n-locality inequality in a network with five nodes and four independent sources, relying only on single-qubit measurements.

Evolutionarily conserved gene modules mediate neurodegenerative dementia in a variety of mouse models and in postmortem brain tissue from patients.

High quality thin films of the intrinsic magnetic topological insulator MnBi₂Te₄ were studied by means of optical spectroscopy in a broad spectral range from THz to UV. By analysing the optical conductivity at room temperature for different thickness, the presence of surface topological states superimposed to the bulk electrodynamics response was highlighted. For the thinnest film, where charge transport is dominated by the Dirac surface states, the interplay between the magnetic phase transition and the topological surface states was investigated. Crossing the Neèl temperature, the optical conductivity measurements indicate the opening of a magnetic gap at the Dirac node