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Showing 1–18 of 18 results
Advanced filters: Author: Pavel Osten Clear advanced filters

  • Here the authors analyzed 3.7 petavoxels of 3D imaging data from 204 mouse brains, aiming to comprehensively characterize diverse morphological and modular patterns conserved across six spatial scales of mouse brain anatomy, ranging from the whole-brain scale to synaptic levels.

    • Yufeng Liu
    • Shengdian Jiang
    • Hanchuan Peng
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-23

  • The neocortex contains a large diversity of interneurons but the subtype-specific roles of these cells in establishing excitatory and inhibitory circuits are not well understood. Here the authors genetically delete parvalbumin- and somatostatin-positive interneurons during mouse development and study the functional effects in postnatal cortical circuits.

    • Naoki Takada
    • Hyun Jae Pi
    • Pavel Osten
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • Multi-modal analysis is used to generate a 3D atlas of the upper limb area of the mouse primary motor cortex, providing a framework for future studies of motor control circuitry.

    • Rodrigo Muñoz-Castañeda
    • Brian Zingg
    • Hong-Wei Dong
    ResearchOpen Access
    Nature
    Volume: 598, P: 159-166

  • Anatomical segmentation of high-resolution 3D microscopy datasets is necessary to map large samples at cellular resolution. Here the authors present a pipeline for automated mouse atlas propagation (aMAP) to segment fluorescence images of the adult mouse brain and validate it against human segmentations.

    • Christian J. Niedworok
    • Alexander P. Y. Brown
    • Troy W. Margrie
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • A combination of genetic strategies and tools is used to define and fate-map different subtypes of glutamatergic pyramidal neurons according to their developmental and molecular programs, providing insight into the assembly of cortical processing networks.

    • Katherine S. Matho
    • Dhananjay Huilgol
    • Z. Josh Huang
    ResearchOpen Access
    Nature
    Volume: 598, P: 182-187

  • Using a rat model of PD, the authors find a progressive decline in autonomous globus pallidus pacemaking. This loss was reversed by viral expression of the HCN channel. However, the motor disability induced by DA depletion was not reversed, suggesting that the loss of pacemaking was a consequence, not a cause, of key network pathophysiology.

    • C Savio Chan
    • Kelly E Glajch
    • D James Surmeier
    Research
    Nature Neuroscience
    Volume: 14, P: 85-92

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • This study uses human astrocytes and glioma tumorspheres to generate an atlas of mutant-IDH1-induced epigenomic reprogramming. The findings have implications for understanding mutant IDH function and for optimizing approaches to target IDH-mutant tumors.

    • Sevin Turcan
    • Vladimir Makarov
    • Timothy A. Chan
    Research
    Nature Genetics
    Volume: 50, P: 62-72

  • A protein has been identified that makes spines grow on nerve cells. Unexpectedly, it also turns out to be part of an ion channel that is responsible for transmitting signals between neurons.

    • Peter H. Seeburg
    • Pavel Osten
    News & Views
    Nature
    Volume: 424, P: 627-628

  • Automated tissue sectioning and two-photon imaging of fluorescently labeled and fixed mouse brains allows high-resolution tomographic imaging of the entire brain. The authors demonstrate performance using multiple GFP mouse lines, dye-based retrograde tracing and viral anterograde tracing.

    • Timothy Ragan
    • Lolahon R Kadiri
    • Pavel Osten
    Research
    Nature Methods
    Volume: 9, P: 255-258

  • The beginning of the 21st century has seen a renaissance in light microscopy and anatomical tract tracing that together are rapidly advancing our understanding of the form and function of neuronal circuits. The introduction of instruments for automated imaging of whole mouse brains, new cell type–specific and trans-synaptic tracers, and computational methods for handling the whole-brain data sets has opened the door to neuroanatomical studies at an unprecedented scale. We present an overview of the present state and future opportunities in charting long-range and local connectivity in the entire mouse brain and in linking brain circuits to function.

    • Pavel Osten
    • Troy W Margrie
    Reviews
    Nature Methods
    Volume: 10, P: 515-523