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Poddar et al. report perovskite nanowire array-based memristors. A thin ITO layer is introduced as a semi-permeable barrier between electrode and perovskite for controllable analog switching. A physical multi-layer perceptron based on a 64×64 crossbar array enables the analysation of zebrafish strike patterns.

AmiAge predicts biological age from plasma amino acids, linking age gaps to frailty, disease risk, and aging markers. An 8-amino acid model offers a scalable tool for personalized health and aging research.

Researchers report five cryo-EM structures of the Arabidopsis peroxisomal transporter CTS, revealing how it imports fatty acids, hormone precursors, and herbicides into peroxisomes for β oxidation.

The study shows that E. coli infection disrupts copper balance by inducing CTR2 through acetylated mitochondrial MDH2, triggering cuproptosis and liver injury, and suggests that targeting this pathway may help limit infection-associated damage.

Cancer relapses after chemotherapy remain the primary challenge in cancer treatment. Here, authors show that bladder tumours recur from quiescent epidermoid-like cells and map how these cells evolve under treatment, identifying insulin-like growth factorbinding protein 5 as a potential target to curb chemoresistance and progression.

Using an observational social defeat model, here authors show NG2 glia in the medial amygdala of observer mice attenuate GABA synthesis and reduce inhibitory tone onto neighboring GABAergic neurons, thereby driving empathy-like allogrooming toward distressed companions.

Laser-based surface treatment creates a hierarchical architecture in superelastic NiTi, integrating hard nitrides, graded grains and phases, and high compressive stress. This synergy suppresses cracking and extends bending fatigue life beyond 5 million cycles.

Using cryo-EM, researchers solve the structure of the TRPC1/5 ion channel complex, revealing a unique drug-binding pocket. This enables design of JD03-02, a selective inhibitor with potential to treat anxiety and depression.

Developing noble-metal-free electrocatalysts for acidic water electrolysis is vital for hydrogen production. The authors design a Cr and Nd co-doped Co3O4 anode catalyst with enhanced activity and durability and introduce an in-situ acid circulation strategy to mitigate membrane poisoning.

Overoxidation remains a selectivity challenge in direct benzylic C–H bond hydroxylation. Here, the authors present an electrochemical method using water as the hydroxyl source and N-methyl-2-pyrrolidone as a co-solvent, effectively suppressing overoxidation without external oxidants or metal catalysts.

Time-division multiplexing in a metropolitan-scale quantum repeater is demonstrated. Heralded entanglement between remote quantum memories is implemented over a distance of 14.5 km, generating a Bell state with a fidelity of 78.6% with a Bell inequality violation of S = 2.22.

Super spreading events are considered important contributors to the spread of COVID−19, but the extent to which superspreading varies by transmission setting is unclear. Here, the authors demonstrate heterogeneity in superspreading and the generation interval between COVID−19 cases in different settings using data from Hong Kong.

The authors propose a 3D holographic method that generates physically consistent complex-valued light fields from multi-layer RGB-D data, achieving photorealistic defocus effects in scenes with transparency and reflection.

Poly(A) tails are critical to gene regulation, yet their organism-wide patterns remain unmapped. Here, the authors provide an 18-organ mouse atlas, revealing that poly(A) dynamics is fundamentally orthogonal to mRNA abundance.

The success of KRAS G12C mutation specific inhibitors in patients with KRAS-driven tumours is limited by the emergence of acquired resistance. Here, the authors characterise olomorasib, a next-generation covalent KRAS G12C-mutant inhibitor, demonstrating efficacy in the presence of clinically relevant resistance mutations in preclinical KRAS-driven cancer models.

A Co/CoO@NC catalyst with an interfacial built-in electric field can activate the endogenous PAA-H₂O₂ redox couple, establishing a self-sustaining catalytic loop that overcomes the activity-stability trade-off in advanced oxidation processes.

Least-cost rural energy pathways shift from natural gas to photovoltaic electricity by the early 2030 s, with premature gas expansion raising lifetime costs by 15 to 40 percent, shown by simulating five transition options for 248000 Chinese settlements with 323.9 million residents from 2025 to 2060.

Mitochondrial cristae structure is essential for energy production and immune regulation, but therapeutic strategies targeting cristae remodeling are lacking. Here, the authors show that targeting triose phosphate isomerase 1 restores cristae architecture, rewires microglial metabolism, and protects against ischemic stroke.

Idiopathic pulmonary fibrosis is a fatal lung disease driven by aberrant fibroblast activation, but the underlying metabolic changes remain unclear. Here, the authors show that dysregulated branched chain amino acid metabolism promotes lung fibrosis and can be therapeutically targeted.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Poor storage stability and soil survival limits agricultural application of non-spore forming bacteria. Here, the authors develop a hydrogel microcapsule which improves storage and soil survival, demonstrating application in improving plant salt tolerance under field conditions.

Autophagic activity has a protective role in Alzheimer’s disease in mice. Here the authors investigate the role of autophagy-initiating protein ULK1 and report that its overexpression stimulates autophagic flux, reduces amyloid and tau pathology and delays cognitive decline.

Each day, among the thousands who cross Luohu Port between Hong Kong and Shenzhen, Dandan Peng finds traces of a city’s soul in the places where people rush through. From here, borders reveal themselves not as barriers but as thresholds.

Traditional single-cell models often overlook the proteomic context of cell phenotypes. Here, authors present CAPTAIN, a multimodal foundation model pretrained on 4.2 million cells. It aligns RNA and protein profiles to enhance cell annotation, protein imputation, and intercellular discovery.

GSCo is a Generalist–Specialist Collaboration that combines the generalizability of generalist foundation models with the domain-specific benefits of specialist models. GSCo remains efficient and scalable while excelling at diverse medical tasks.

Understanding the subcellular distribution of RNA-binding proteins can shed light on their structural and functional features. Here, the authors map RNA-binding proteins across cellular compartments, revealing hierarchies and atypical functions.

Making useful nitrogen compounds directly from nitrogen gas and simple aromatic molecules has been a major chemical challenge. A sodium hydride magnesium oxide surface enables direct carbon–nitrogen bond formation and selectively produces aniline.

This study shows that the EBF2 activates brown fat through biomolecular condensation. Disrupting EBF2 condensates impairs thermogenic gene expression, while small molecules that modulate condensate dynamics improve thermogenic programming.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

This study shows that novelty exposure alleviates pain and anxiety in mice by activating a specific ensemble of neurons in the lateral hypothalamus, revealing distinct neural circuits that mediate the therapeutic benefits of attention distraction.

In this study, the authors find that SHANK3’s large intrinsically disordered region mediates phase separation to support postsynaptic density remodeling during long-term potentiation, providing an insight into how autism spectrum disorder-linked SHANK3 mutations disrupt synaptic plasticity.

Global forests show extensive tree-cover loss. Here, the authors report that plant attributes and functions can increase under limited tree-cover loss, but also that this safety margin due to edge effects from fragmentation has already been exceeded in 35.7% of forests globally.

Governments are considering subsidies for bioenergy with carbon capture and storage fuelled by wood from existing forests. However, a transparent model estimates that this will probably increase emissions for decades, increase electricity costs 3.5-fold and not generate negative emissions for 150 years.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8⁺ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.

This study reveals that enhanced autophagy in root-hair-forming cells helps Arabidopsis store excess sodium, control oxidative stress and tolerate salt stress.

The rapid expansion of urban logistics networks brings a substantial, yet hidden, environmental cost to our cities. Leveraging smartphone delivery logs from couriers, new research now quantifies the fine-grained greenhouse-gas footprints of last-mile delivery processes, which enables the exploration of actionable strategies for sustainable urban logistics.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

Genomic epidemiology of 1,029 Streptococcus pyogenes emm1 and emm12 genome sequences collected between 1993 and 2024 in China reveals dominance of distinct lineages with mobile genetic element-encoded antibiotic resistance and virulence factor genes.

Cases linked to superspreading events are estimated to account for 80% of all local transmission of SARS-CoV-2 in Hong Kong in a study with implications for public health policies.

The Neuroimaging Foundation Model with Spatial–Temporal Optimized and Representation Modelling (NeuroSTORM) learns generalizable representations from 4D functional MRI volumes, enabling accurate performance on diverse tasks such as diagnosis and state classification.