Nature Search

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

Using single-cell RNA-seq, the authors produced a comprehensive atlas of the somatosensory spinal cord. They found that neuron types build the dorsal horn by a discrete layering and to be differentially engaged by noxious heat and cold.

Martin Häring
Amit Zeisel
Patrik Ernfors
Research23 Apr 2018
Nature Neuroscience

Volume: 21, P: 869-880
Striking convergent selection history of wheat and barley and its potential for breeding

Convergent selection between crops can help to identify genetic variants with important roles in adaptation as a source of diversity for the improvement of cultivated species through the concept of inter-crop translational research for breeding.

Mamadou Dia Sow
Cristian Forestan
Jerome Salse
ResearchOpen Access17 Nov 2025
Nature Plants

Volume: 11, P: 2268-2285
Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity

Sascha R. A. Alles
Max A. Odem
Peter A. Smith
ResearchOpen Access26 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
SLC45A4 is a pain gene encoding a neuronal polyamine transporter

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Steven J. Middleton
Sigurbjörn Markússon
David L. Bennett
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 404-412
Global risk of selection and spread of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions

A modeling approach to assess the global risk of Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions identifies ten priority African countries for surveillance and could inform malaria control policies.

Oliver J. Watson
Thu Nguyen-Anh Tran
Jane Cunningham
ResearchOpen Access06 Oct 2025
Nature Medicine

Volume: 31, P: 3372-3379
Addendum: Resolving data bias improves generalization in binding affinity prediction

David Graber
Peter Stockinger
Rebecca Buller
Amendments and Corrections27 Jan 2026
Nature Machine Intelligence

P: 1
Seleno-Cystathionine, a Pharmacologically Active Factor in the Seeds of Lecythis ollaria: Structure of the Pharmacologically Active Factor in the Seeds of Lecythis ollaria

FRANCISCO KERDEL-VEGAS
FRITZ WAGNER
JAMES A. MILLER
Research01 Mar 1965
Nature

Volume: 205, P: 1186-1187
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

Ruizhong Wang
Tamara King
Frank Porreca
Research23 Mar 2008
Nature Neuroscience

Volume: 11, P: 488-496
TDP-43-dependent mis-splicing of KCNQ2 triggers intrinsic neuronal hyperexcitability in ALS/FTD

TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based therapies.

Brian J. Joseph
Kelly A. Marshall
Evangelos Kiskinis
ResearchOpen Access31 Oct 2025
Nature Neuroscience

Volume: 28, P: 2476-2492
Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis

Peter Klivenyi
Robert J. Ferrante
M. Flint Beal
Research01 Mar 1999
Nature Medicine

Volume: 5, P: 347-350
Distinct local and global functions of mouse Aβ low-threshold mechanoreceptors in mechanical nociception

The mechanism underlying mechanical hyperalgesia is not fully understood. Here authors show opposing roles of tactile afferents in mechanical nociception using mouse pain models.

Mayank Gautam
Akihiro Yamada
Wenqin Luo
ResearchOpen Access04 Apr 2024
Nature Communications

Volume: 15, P: 1-19
Fibromyalgia: A Unifying Neuroendocrinologic Model for Understanding Its Pathophysiology

Peter Dorsher
ResearchOpen Access04 Dec 2008
Nature Precedings

P: 1
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration

Bert Oosthuyse
Lieve Moons
Peter Carmeliet
Research01 Jun 2001
Nature Genetics

Volume: 28, P: 131-138
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Peripheral nerve injury triggers central sprouting of myelinated afferents

Clifford J. Woolf
Peter Shortland
Richard E. Coggeshall
Research02 Jan 1992
Nature

Volume: 355, P: 75-78
Markedly Reduced Activity of Lysyl Oxidase in Skin and Aorta from a Patient with Menkes' Disease Showing Unusually Severe Connective Tissue Manifestations

Peter M Royce
Beat Steinmann
Research01 Aug 1990
Pediatric Research

Volume: 28, P: 137-141
Evidence for a role of Anopheles stephensi in the spread of drug- and diagnosis-resistant malaria in Africa

Evidence that a dry-season outbreak of malaria in Dire Dawa, Ethiopia is caused by Anopheles stephensi carrying Plasmodium falciparum with diagnostic and drug resistance mutations calls for heightened vector surveillance in both urban and rural settings.

Tadele Emiru
Dejene Getachew
Fitsum G. Tadesse
ResearchOpen Access26 Oct 2023
Nature Medicine

Volume: 29, P: 3203-3211
Phosphorylated Histone 3 at Serine 10 Identifies Activated Spinal Neurons and Contributes to the Development of Tissue Injury-Associated Pain

Jose Vicente Torres-Pérez
Péter Sántha
Istvan Nagy
ResearchOpen Access25 Jan 2017
Scientific Reports

Volume: 7, P: 1-17
Embryo-endometrial interaction associated with the location of the embryo during the mobility phase in mares

Thadeu de Castro
Machteld van Heule
Pouya Dini
ResearchOpen Access07 Feb 2024
Scientific Reports

Volume: 14, P: 1-13
Positive allosteric mechanisms of adenosine A₁ receptor-mediated analgesia

MIPS521, a positive allosteric modulator of the adenosine A₁ receptor, has analgesic properties in a rat model of neuropathic pain through a mechanism by which MIPS521 stabilizes the complex between adenosine, receptor and G protein.

Christopher J. Draper-Joyce
Rebecca Bhola
Arthur Christopoulos
Research08 Sept 2021
Nature

Volume: 597, P: 571-576
Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

Central axons have limited regenerative ability following injury. Here, the authors show that chronic activation of DRG neurons results in highly dynamic microtubules at the distal axons and enhanced axonal regrowth and synaptogenesis in the spinal cord affecting functional recovery.

Di Wu
Ying Jin
Veronica J. Tom
ResearchOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1-16
Pauling's model not universally accepted

PETER A. BANCEL
PAUL A. HEINEY
ALAN I. GOLDMAN
Research09 Jan 1986
Nature

Volume: 319, P: 104
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain

Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into the brain parenchyma of rodents.

Shelei Pan
Peter H. Yang
Jennifer M. Strahle
ResearchOpen Access27 Jan 2023
Nature Communications

Volume: 14, P: 1-16
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ⁹-tetrahydrocannabiorcol

TRPA1 is a key ion channel in pain signalling. This study shows that activation of TRPA1 in the spinal cord by acetaminophen metabolites and a non-electrophilic cannabinoid produces antinociception that is lost in mice lacking TRPA1, providing an explanation for the analgesic activity of acetaminophen.

David A Andersson
Clive Gentry
Peter M Zygmunt
Research22 Nov 2011
Nature Communications

Volume: 2, P: 1-11
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

Nitin Agarwal
Pal Pacher
Rohini Kuner
Research10 Jun 2007
Nature Neuroscience

Volume: 10, P: 870-879
TGFα controls checkpoints in CNS resident and infiltrating immune cells to promote resolution of inflammation

Some brain lesions recover in multiple sclerosis, while others do not; however, the underlying mechanisms are unclear. Here, the authors show that microglia-derived TGFα orchestrates immune control and tissue repair, and that intranasal delivery of TGFα in the autoimmune encephalomyelitis model promotes lesion resolution.

Lena Lößlein
Mathias Linnerbauer
Veit Rothhammer
ResearchOpen Access19 Jun 2025
Nature Communications

Volume: 16, P: 1-17
Resolving data bias improves generalization in binding affinity prediction

Graber et al. characterize biases and data leakage in protein–ligand datasets and show that a cleanly filtered training–test split leads to improved generalization in binding affinity prediction tasks.

David Graber
Peter Stockinger
Rebecca Buller
ResearchOpen Access21 Oct 2025
Nature Machine Intelligence

Volume: 7, P: 1713-1725
Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q

John G. Compton
John J. DiGiovanna
Sherri J. Bale
Research01 Jul 1992
Nature Genetics

Volume: 1, P: 301-305
Editorial Expression of Concern: Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer

Christine M. Lovly
Nerina T. McDonald
William Pao
Amendments and Corrections20 Nov 2025
Nature Medicine

Volume: 31, P: 4316
Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor

Philippe Naveilhan
Hessameh Hassani
Patrik Ernfors
Research25 Jan 2001
Nature

Volume: 409, P: 513-517
Genomics of a sexually selected sperm ornament and female preference in Drosophila

A comparative analysis of morphological data across 149 species of Drosophilidae shows that sperm length in males has co-evolved with the length of the sperm-storage organ in females. Combining a genome-wide association study of these traits in Drosophila melanogaster with molecular evolutionary analyses of the genomes of 15 Drosophila species, the authors find that the genetic architecture underlying sperm length is associated with indirect genetic benefits in females, providing support for the ‘good genes’ hypothesis.

Zeeshan A. Syed
R. Antonio Gomez
Scott Pitnick
Research22 Nov 2024
Nature Ecology & Evolution

Volume: 9, P: 336-348
A catalog of genetic loci associated with kidney function from analyses of a million individuals

Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.

Matthias Wuttke
Yong Li
Cristian Pattaro
Research31 May 2019
Nature Genetics

Volume: 51, P: 957-972
Phosphorylase Activity in Acutely Exercised Muscle

V. R. EDGERTON
DONALD SIMPSON
J. B. PETER
Research28 Feb 1970
Nature

Volume: 225, P: 866-867
Vascular endothelial growth factor is essential for corpus luteum angiogenesis

Napoleone Ferrara
Helen Chen
Ralph H. Schwall
Research01 Mar 1998
Nature Medicine

Volume: 4, P: 336-340
Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human

Amirali Toossi
Bradley Bergin
Vivian K. Mushahwar
ResearchOpen Access21 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
A ceratopsian dinosaur from China and the early evolution of Ceratopsia

Xing Xu
Peter J. Makovicky
Hai-lu You
Research21 Mar 2002
Nature

Volume: 416, P: 314-317
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

Diether Lambrechts
Erik Storkebaum
Peter Carmeliet
Research06 Jul 2003
Nature Genetics

Volume: 34, P: 383-394
Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury

Jan Hoeber
Carl Trolle
Elena N. Kozlova
ResearchOpen Access08 Jun 2015
Scientific Reports

Volume: 5, P: 1-17
Pathological pain and the neuroimmune interface

Here, the authors describe the immune mechanisms that are involved in pain, one of the key features of inflammation. They explain how the immune and nervous systems interact to initiate and propagate pain, and discuss the immune components that can be targeted for alleviating pathological pain in patients.

Peter M. Grace
Mark R. Hutchinson
Linda R. Watkins
Reviews28 Feb 2014
Nature Reviews Immunology

Volume: 14, P: 217-231
Hormonally mediated inheritance of acquired characteristics in Mongolian gerbils

Mertice M. Clark
Peter Karpiuk
Bennett G. Galef Jr
Research19 Aug 1993
Nature

Volume: 364, P: 712
Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord

Spinal CPGs transmit movement commands through rhythmic synaptic drive onto the spinal premotor network. Here, the authors use paired recordings to demonstrate that spinal neurons have decorrelated synaptic activity suggesting a CPG network with sparse convergent connectivity.

Marija Radosevic
Alex Willumsen
Rune W. Berg
ResearchOpen Access03 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Unforeseen plant phenotypic diversity in a dry and grazed world

Analysis of 20 chemical and morphological plant traits at diverse sites across 6 continents shows that the transition from semi-arid to arid zones is associated with an unexpected 88% increase in trait diversity.

Nicolas Gross
Fernando T. Maestre
Yoann Le Bagousse-Pinguet
Research07 Aug 2024
Nature

Volume: 632, P: 808-814
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Ruth Loos and colleagues report a meta-analysis of genome-wide association studies in 181,171 individuals identifying 14 new loci associated with heart rate and test these for association with cardiac conduction, rhythm disorders and cardiovascular disease. Their experimental studies in Drosophila melanogaster and zebrafish models provide support for a role for 20 candidate genes at 11 of these loci in regulation of heart rate.

Marcel den Hoed
Mark Eijgelsheim
Ruth J F Loos
Research14 Apr 2013
Nature Genetics

Volume: 45, P: 621-631
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
A new species of living bovid from Vietnam

Vu Van Dung
Pham Mong Giao
John MacKinnon
Research03 Jun 1993
Nature

Volume: 363, P: 443-445
TRPV3 is a calcium-permeable temperature-sensitive cation channel

Haoxing Xu
I. Scott Ramsey
David E. Clapham
Research23 Jun 2002
Nature

Volume: 418, P: 181-186
Dopamine-like effects of cholera toxin in the central nervous system

RICHARD J. MILLER
PETER H. KELLY
Research08 May 1975
Nature

Volume: 255, P: 163-166
Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons

Jinsong Li
Tomohiro Ishii
Peter Mombaerts
Research25 Mar 2004
Nature

Volume: 428, P: 393-399

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